{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:44:04Z","timestamp":1787064244662,"version":"build-2736575974"},"reference-count":88,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Among many antiretroviral drugs, tenofovir alafenamide is used extensively in combination regimens of tenofovir\/emtricitabine or tenofovir\/emtricitabine\/bictegravir. However, concerns have arisen about the potential of tenofovir alafenamide to exacerbate hyperlipidaemia. This meta\u2010analysis evaluates the relationship between tenofovir alafenamide use and lipid\u2010profile alterations in people living with HIV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed, Ovid MEDLINE, EMBASE and the Cochrane Library to identify studies on changes in cholesterol levels (e.g. total cholesterol, low\u2010density and high\u2010density lipoprotein cholesterol, and triglycerides) in people living with HIV who received treatment with a regimen containing tenofovir alafenamide (data collected 31 March 2023, review completed 30 July 2023). Potential risk factors for worsening lipid profile during treatment with tenofovir alafenamide were also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty\u2010five studies involving 39,713 people living with HIV were selected. Significant increases in total cholesterol, low\u2010density and high\u2010density lipoprotein cholesterol, and triglycerides were observed after treatment with tenofovir alafenamide. Specifically, low\u2010density lipoprotein cholesterol (+12.31 mg\/dl) and total cholesterol (+18.86 mg\/dl) increased markedly from the third month of tenofovir alafenamide use, with significant elevations observed across all time points up to 36 months. Comparatively, tenofovir alafenamide regimens resulted in higher lipid levels than tenofovir disoproxil fumarate regimens at 12 months of use. Notably, discontinuation of the tenofovir alafenamide regimen led to significant decreases in low\u2010density lipoprotein cholesterol (\u20139.31 mg\/dl) and total cholesterol (\u20138.91 mg\/dl). Additionally, tenofovir alafenamide use was associated with increased bodyweight (+1.38 kg; 95% confidence interval: 0.92\u20131.84), which became more pronounced over time. Meta\u2010regression analysis identified young age, male sex and low body mass index as risk factors for worsening cholesterol levels in individuals treated with tenofovir alafenamide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Tenofovir alafenamide use in people living with HIV is associated with significant alterations in lipid profile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jia2.26358","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T04:26:10Z","timestamp":1726806370000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Risk of dyslipidaemia in people living with HIV who are taking tenofovir alafenamide: a systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7802-0381","authenticated-orcid":false,"given":"Jeong\u2010Ju","family":"Yoo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Soonchunhyang University Bucheon Hospital Soonchunhyang University College of Medicine  Bucheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Ae","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Medical Library Soonchunhyang University Bucheon Hospital Soonchunhyang University College of Medicine  Bucheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Gyune","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Soonchunhyang University Bucheon Hospital Soonchunhyang University College of Medicine  Bucheon Republic of 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