{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:59:51Z","timestamp":1791518391636,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013074","name":"Lake Forest College","doi-asserted-by":"publisher","award":["K23 AG084415"],"award-info":[{"award-number":["K23 AG084415"]}],"id":[{"id":"10.13039\/100013074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Perspectives on long\u2010acting injectable cabotegravir\/rilpivirine (CAB\/RPV\u2010LA) from HIV health disparity populations are under\u2010represented in current literature yet crucial to optimize delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between August 2022 and May 2023, we conducted in\u2010depth interviews with people with HIV (PWH) at four HIV clinics in Atlanta, Chicago and San Francisco. Eligibility criteria were current CAB\/RPV\u2010LA use with receipt of \u22653 injections or CAB\/RPV\u2010LA discontinuation. We purposefully sampled for PWH who initiated with viraemia (plasma HIV RNA &gt;50 copies\/ml) due to adherence challenges, discontinuers, and cis and trans women. Interviews were coded and analysed using thematic methods grounded in descriptive phenomenology. Clinical data were abstracted from the medical record.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The sample (San Francisco <jats:italic>n<\/jats:italic> = 25, Atlanta <jats:italic>n<\/jats:italic> = 20, Chicago <jats:italic>n<\/jats:italic> = 14 for total <jats:italic>n<\/jats:italic> = 59, median number of injections = 6) consisted of 48 PWH using CAB\/RPV\u2010LA and 11 who had discontinued. The median age was 50 (range 25\u201373) and 40 (68%) identified as racial\/ethnic minorities, 19 (32%) cis or trans women, 16 (29%) were experiencing homelessness\/unstable housing, 12 (20%) had recently used methamphetamine or opioids and 11 (19%) initiated with viraemia. All participants except one (who discontinued) had evidence of viral suppression at interview. Typical benefits of CAB\/RPV\u2010LA included increased convenience, privacy and freedom from being reminded of HIV and reduced anxiety about forgetting pills. However, PWH who became virally suppressed through CAB\/RPV\u2010LA use also experienced an amelioration of feelings of shame and negative self\u2010worth related to oral adherence challenges. Regardless of baseline viral suppression status, successful use of CAB\/RPV\u2010LA amplified positive provider\/clinic relationships, and CAB\/RPV\u2010LA was often viewed as less \u201cwork\u201d than oral antiretroviral therapy, which created space to attend to other aspects of health and wellness. For some participants, CAB\/RPV\u2010LA remained \u201cwork,\u201d particularly with regard to injection site pain and visit frequency. At times, these burdens outweighed the aforementioned benefits, resulting in discontinuation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CAB\/RPV\u2010LA offers a range of logistical, psychosocial and care engagement benefits, which are experienced maximally by PWH initiating with viraemia due to adherence challenges; however, benefits do not always outweigh treatment burdens and can result in discontinuation. Our findings on rationales for persistence versus discontinuation can inform both initial and follow\u2010up patient counselling.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jia2.26394","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T05:44:02Z","timestamp":1732167842000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Learning from the first: a qualitative study of the psychosocial benefits and treatment burdens of long\u2010acting cabotegravir\/rilpivirine among early adopters in three U.S. clinics"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8598-2191","authenticated-orcid":false,"given":"Katerina A.","family":"Christopoulos","sequence":"first","affiliation":[{"name":"Department of Medicine University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mollie 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