{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T01:29:03Z","timestamp":1793842143544,"version":"4.6.1"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,24]],"date-time":"2024-11-24T00:00:00Z","timestamp":1732406400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>HIV pre\u2010exposure prophylaxis (PrEP) has been publicly available since 2018 in Australia as a daily regimen. In 2019, clinical guidelines were updated to support guidance on event\u2010driven PrEP (ED\u2010PrEP) use. We assessed trends in the PrEP dosing regimen by comparing daily PrEP use to ED\u2010PrEP among cisgender gay, bisexual and other men who have sex with men (GBMSM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from repeated, cross\u2010sectional, national behavioural surveillance surveys were analysed from 2019 to 2023 among participants not living with HIV. Logistic regression models were conducted to assess trends and compared ED\u2010PrEP users to non\u2010PrEP users and daily PrEP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 38,880 participants, overall PrEP use with any regimen increased from 27.6% in 2019 to 42.7% in 2023 (OR = 1.16, 95% CI = 1.15\u22121.18,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Among 12,922 participants who reported PrEP use in the last 6\u00a0months, the proportion reporting ED\u2010PrEP use increased from 7.6% in 2019 to 27.8% in 2023 (OR = 1.41, 95% CI = 1.37\u22121.46,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) with those who reported daily PrEP decreasing from 92.4% to 63.3% (OR = 0.64, 95% CI = 0.62\u22120.66,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). In a cross\u2010sectional sub\u2010sample in 2022\u20132023 (\n                      <jats:italic>n<\/jats:italic>\n                      = 8840), compared to ED\u2010PrEP users, non\u2010PrEP users were less likely to have received three or more HIV tests in the last 12 months (aRRR = 0.26, 95% CI = 0.22\u22120.31,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), have 2\u221210 male sexual partners in the last 6\u00a0months (aRRR = 0.24, 95% CI = 0.14\u22120.41,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) or 11 or more (aRRR = 0.26, 95% CI = 0.15\u22120.45,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) compared to none, or to report condomless anal intercourse with casual partners (aRRR = 0.38, 95% CI = 0.32\u22120.46,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Compared to ED\u2010PrEP users, daily PrEP users were more likely to have received three of more HIV tests in the last year (aRRR = 3.73, 95% CI = 3.15\u22124.40,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) and less likely to be born overseas and lived in Australia for less than 5 years compared to being born in Australia (aRRR = 0.64, 95% CI = 0.49\u22120.83,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While daily PrEP remains the most common PrEP dosing regimen among GBMSM in Australia, there has been a steep increase in the proportion of PrEP users who are taking ED\u2010PrEP. Monitoring of PrEP use should continue to adapt to new dosing methods and future PrEP options. As ED\u2010PrEP use increases, further work is needed to ensure those taking ED\u2010PrEP are taking it effectively to prevent HIV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jia2.26398","type":"journal-article","created":{"date-parts":[[2024,11,24]],"date-time":"2024-11-24T21:46:52Z","timestamp":1732484812000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Increasing event\u2010driven HIV pre\u2010exposure prophylaxis use among gay, bisexual and other men who have sex with men in Australia: results from behavioural surveillance 2019\u20132023"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9581-1011","authenticated-orcid":false,"given":"Curtis","family":"Chan","sequence":"first","affiliation":[{"name":"Kirby Institute, UNSW Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2586-8274","authenticated-orcid":false,"given":"Martin","family":"Holt","sequence":"additional","affiliation":[{"name":"Centre for Social Research in Health, UNSW Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0005-9542","authenticated-orcid":false,"given":"Anthony K. J.","family":"Smith","sequence":"additional","affiliation":[{"name":"Centre for Social Research in Health, UNSW Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4341-1868","authenticated-orcid":false,"given":"Timothy R.","family":"Broady","sequence":"additional","affiliation":[{"name":"Centre for Social Research in Health, UNSW Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1359-9572","authenticated-orcid":false,"given":"James","family":"MacGibbon","sequence":"additional","affiliation":[{"name":"Centre for Social Research in Health, UNSW Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0995-5789","authenticated-orcid":false,"given":"Limin","family":"Mao","sequence":"additional","affiliation":[{"name":"Centre for Social Research in Health, UNSW Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Wilcock","sequence":"additional","affiliation":[{"name":"Health Equity Matters  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7518-7744","authenticated-orcid":false,"given":"John","family":"Rule","sequence":"additional","affiliation":[{"name":"National Association of People with HIV Australia  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5834-8278","authenticated-orcid":false,"given":"Benjamin R.","family":"Bavinton","sequence":"additional","affiliation":[{"name":"Kirby Institute, UNSW Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,24]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"World Health Organization.What's the 2+1+1? 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