{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:43:55Z","timestamp":1785224635022,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:00:00Z","timestamp":1744070400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001117","name":"amfAR, The Foundation for AIDS Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001117","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We assessed the long\u2010term HIV\u2010related health outcomes of young adults with perinatally acquired HIV (PHIV) compared with those who acquired HIV through sexual transmission in the Asia\u2010Pacific region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a cross\u2010sectional study using data from three paediatric and adult cohorts within the International epidemiology Databases to Evaluate AIDS (IeDEA) Asia\u2010Pacific consortium. This study included data from 12 countries, collected between 1991 and 2021. Young adults with available data who had been on antiretroviral therapy (ART) for at least 1 year were included. Analyses were conducted at ages 18 and 25 years and compared by route of HIV acquisition. Factors associated with viral suppression (&lt;200 copies\/ml) at age 25 were identified using logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 1333 individuals included at age 18 (96% with PHIV: 46% male) and 305 at age 25 (27% with PHIV; 75% male). Compared to those with sexually acquired HIV at age 18, those with PHIV had a longer median duration of ART (10 vs. 4 years, <jats:italic>p&lt;<\/jats:italic>0.001), higher current CD4 count (606 vs. 462 cells\/mm<jats:sup>3<\/jats:sup>, <jats:italic>p =<\/jats:italic> 0.001), were shorter (height 158 vs. 166 cm, <jats:italic>p&lt;<\/jats:italic>0.001), with more hypercholesterolemia (20% vs. 5%, <jats:italic>p<\/jats:italic> = 0.031) and hypertriglyceridemia (29% vs. 6% mg\/dl, <jats:italic>p<\/jats:italic> = 0.003). At age 25, differences in duration of ART (15 vs. 3 years, <jats:italic>p&lt;<\/jats:italic>0.001), male height (165 vs. 173 cm, <jats:italic>p =<\/jats:italic> 0.009) and proportion with hypertriglyceridemia (38% vs. 15%, <jats:italic>p =<\/jats:italic> 0.002) were observed. HIV viral suppression did not vary by mode of acquisition (89% vs. 87% at age 18; 91% vs. 85% at age 25). At age 25, living in Thailand (adjusted odds ratio [AOR] 6.05, 95% confidence interval [CI] 1.95\u221218.80) and use of integrase inhibitor\u2010based regimens (AOR 5.20, 95% CI 1.62\u221216.65) or protease inhibitor\u2010based regimens (AOR 2.62, 95% CI 1.01\u22126.79) were associated with viral suppression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Young adults with PHIV who survived to ages 18 and 25 were more likely to have stunted growth but had similar viral suppression to those with sexually acquired HIV in our regional cohorts. However, viral suppression rates remained lower for all relative to the UNAIDS goal of 95%, and measures to improve treatment outcomes are needed for young adults.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jia2.26400","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T05:50:48Z","timestamp":1744177848000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Differences in clinical characteristics between adolescents and young adults with perinatally and sexually acquired HIV in the Asia\u2010Pacific region"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8456-840X","authenticated-orcid":false,"given":"Phatharajit","family":"Phatharodom","sequence":"first","affiliation":[{"name":"Department of Preventive and Social Medicine Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Maleesatharn","sequence":"additional","affiliation":[{"name":"Siriraj Institute of Clinical Research and Department of Pediatrics Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3686-4623","authenticated-orcid":false,"given":"Tavitiya","family":"Sudjaritruk","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"},{"name":"Clinical and Molecular Epidemiology of Emerging and Re\u2010emerging Infectious Diseases Research Cluster, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6975-057X","authenticated-orcid":false,"given":"Suwimon","family":"Khusuwan","sequence":"additional","affiliation":[{"name":"Chiangrai Prachanukroh Hospital  Chiang Rai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Petoumenos","sequence":"additional","affiliation":[{"name":"The Kirby Institute UNSW Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0246-8187","authenticated-orcid":false,"given":"Linda","family":"Aurpibul","sequence":"additional","affiliation":[{"name":"Research Institute for Health Sciences Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romanee","family":"Chaiwarith","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Tropical Medicine Department of Medicine, Faculty of Medicine and Research Institute for Health Sciences Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3007-1822","authenticated-orcid":false,"given":"Michelle L.","family":"Giles","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Alfred Hospital and Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du Tuan","family":"Quy","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Children's Hospital 1  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smita","family":"Nimkar","sequence":"additional","affiliation":[{"name":"BJ Government Medical College \u2013 Johns Hopkins University Clinical Research Site Pune  Pune India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvina","family":"Widhani","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universitas Indonesia \u2010 Dr. Cipto Mangunkusumo General Hospital  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1697-7364","authenticated-orcid":false,"given":"Junko","family":"Tanuma","sequence":"additional","affiliation":[{"name":"National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Law","sequence":"additional","affiliation":[{"name":"The Kirby Institute UNSW Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0209-3285","authenticated-orcid":false,"given":"Annette H.","family":"Sohn","sequence":"additional","affiliation":[{"name":"TREAT Asia\/amfAR, The Foundation for AIDS Research  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0140-4600","authenticated-orcid":false,"given":"Kulkanya","family":"Chokephaibulkit","sequence":"additional","affiliation":[{"name":"Siriraj Institute of Clinical Research and Department of Pediatrics Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"IeDEA Asia\u2010Pacific","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,8]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"UNAIDS.UNAIDS Data 2022 | reference 2022 [14 AUG 2023]. Accessed 14 August 2022. Available from:https:\/\/www.unaids.org\/sites\/default\/files\/media_asset\/data\u2010book\u20102022_en.pdf"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.2.190"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000660"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000663"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.19.1.20683"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.02.003"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw213"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e318199072e"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.157.3.249"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.159.8.764"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2024.2325100"},{"key":"e_1_2_12_13_1","unstructured":"UNAIDS.DATA 2022.Geneva:Joint United Nations Programme on HIV\/AIDS;2022."},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2009.00207.x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.1.e52"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-022-03626-2"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2190"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.3728"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.033369"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000004340"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215541"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06016-8"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.2165\/11633630-000000000-00000"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0270855"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12981-022-00447-2"}],"container-title":["Journal of the International AIDS Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jia2.26400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T10:24:49Z","timestamp":1747736689000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jia2.26400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/jia2.26400"],"URL":"https:\/\/doi.org\/10.1002\/jia2.26400","archive":["Portico"],"relation":{},"ISSN":["1758-2652","1758-2652"],"issn-type":[{"value":"1758-2652","type":"print"},{"value":"1758-2652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2024-07-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e26400"}}