{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:12:10Z","timestamp":1791882730871,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["1U01AI150510"],"award-info":[{"award-number":["1U01AI150510"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Injectable cabotegravir (CAB\u2010LA) is highly effective for HIV prevention, but real\u2010world implementation studies in Africa are ongoing. We assessed feasibility and acceptability among participants who used CAB\u2010LA in the SEARCH Dynamic Choice HIV Prevention extension study in rural Uganda and Kenya.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From January 2023 to December 2024, we followed females and males who were aged \u2265 15 years, with self\u2010assessed risk for HIV acquisition, in the intervention arm of the SEARCH Dynamic Choice HIV Prevention extension study, and received at least one CAB\u2010LA injection during the first 48 weeks. To assess the feasibility and acceptability of CAB\u2010LA, we designed quantitative surveys based on the Theoretical Framework for Acceptability. Surveys were administered at CAB\u2010LA initiation, after 24 and 48 weeks of use, and discontinuation of CAB\u2010LA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 487 intervention arm participants, 274 (56%) started CAB\u2010LA (183 females; 91 males; 79 youth aged 15\u201324 years). Of whom, 264 completed the survey at initiation, 206 after 24 weeks on CAB\u2010LA, 201 after 48 weeks on CAB\u2010LA and 69 at discontinuation of CAB\u2010LA. Most participants (65%; 171\/264) reported choosing CAB\u2010LA because it was easier to take than pills, and nearly all (99%; 261\/264) had limited knowledge of CAB\u2010LA prior to the study. Concerns for side effects were the largest anticipated and experienced barrier to CAB\u2010LA. Overall and with subgroups, satisfaction with CAB\u2010LA was high at 24 weeks (97%; 200\/206) and 48 weeks (96%; 193\/201). Nearly all participants reported that taking CAB\u2010LA was easy at 24 weeks (95%; 195\/206) and 48 weeks (99%; 198\/201). At CAB\u2010LA discontinuation, 83% (57\/69) were likely to extremely likely to recommend CAB\u2010LA to a friend: 80% (20\/25) of males, 84% (37\/44) of females, 100% (19\/19) of youth and 76% (38\/50) of older adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In rural Uganda and Kenya, over half of participants in the SEARCH trial who were offered choice of oral PrEP\/PEP or CAB\u2010LA chose and started CAB\u2010LA during the first 48 weeks. For both males and females and younger and older adults, CAB\u2010LA was both feasible and acceptable to deliver with satisfaction remaining high throughout the study, and nearly all reporting ease of use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Trial Number<\/jats:title><jats:p>05549726<\/jats:p><\/jats:sec>","DOI":"10.1002\/jia2.26465","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T07:27:47Z","timestamp":1751441267000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Feasibility and acceptability of persons on long\u2010acting cabotegravir for HIV prevention in the SEARCH Dynamic Choice HIV Prevention trial extension in rural Kenya and Uganda: a longitudinal cohort study"],"prefix":"10.1002","volume":"28","author":[{"given":"Elijah R.","family":"Kakande","sequence":"first","affiliation":[{"name":"Infectious Diseases Research Collaboration  Kampala 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