{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T10:23:39Z","timestamp":1752229419926,"version":"3.41.2"},"reference-count":22,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["GH002150"],"award-info":[{"award-number":["GH002150"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006085","name":"Office of Disease Prevention","doi-asserted-by":"publisher","award":["D43TW009343"],"award-info":[{"award-number":["D43TW009343"]}],"id":[{"id":"10.13039\/100006085","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We examined the association of pre\u2010exposure prophylaxis (PrEP) programme retention with the use of daily, event\u2010driven (ED) or regimen switching reported during follow\u2010up at any point prior to discontinuation among men who have sex with men (MSM) in Hanoi, Vietnam.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between April 2020 and February 2023, we collected data from PrEP clients at Hanoi Medical University Sexual Health Promotion clinic who were prescribed either ED or daily PrEP at the initial visit; at subsequent visits, clients reported the regimen used since the prior visit. We defined three categories of PrEP use: ED\u2010PrEP exclusively, daily PrEP exclusively and switching regimens. The primary outcome was time to discontinuation in the PrEP programme during the study period, defined as missing a scheduled visit by &gt;\u00a030 days. We performed survival analysis using Kaplan\u2212Meier curves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 2107 people were included: 61.1% (<jats:italic>n<\/jats:italic> = 1288) reported exclusive use of daily PrEP, 10.4% (<jats:italic>n<\/jats:italic> = 220) reported exclusive use of ED\u2010PrEP and 28.4% (<jats:italic>n<\/jats:italic> = 599) reported switching PrEP regimens. Among switchers, 29.40% (<jats:italic>n<\/jats:italic> = 176) switched more than once. Furthermore, 82.5% switched from daily to ED\u2010PrEP and 17.5% switched from ED to daily PrEP. The median time to discontinuation in the PrEP programme was 105 days (IQR: 52\u2212182) among those reporting exclusive use of ED\u2010PrEP, 104 days (IQR: 56\u2212274) among those reporting exclusive use of daily PrEP and 163 days (IQR: 101\u2212308) among those who switched. Among switchers, those who switched more than once had a median time to discontinuation in the PrEP programme of 231 days (IQR: 137\u2212380) in comparison to 133 days (IQR: 90\u2212274) for those who switched once.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We provide real\u2010world data from MSM in an HIV PrEP programme in Vietnam that those who switched had longer periods of retention during the study period. Our findings suggest that offering flexible PrEP regimen options may improve engagement and long\u2010term adherence among this population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jia2.26478","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T07:35:19Z","timestamp":1751441719000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of changing pre\u2010exposure prophylaxis regimens on retention among men who have sex with men in Hanoi, Vietnam (2020\u22122023): a cohort study"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9654-1162","authenticated-orcid":false,"given":"Naira","family":"Setrakian","sequence":"first","affiliation":[{"name":"Department of Epidemiology UCLA Fielding School of Public Health  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7990-8091","authenticated-orcid":false,"given":"Hao Thi Minh","family":"Bui","sequence":"additional","affiliation":[{"name":"Hanoi Medical University  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2776-6458","authenticated-orcid":false,"given":"Paul C.","family":"Adamson","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thai N.","family":"Hoang","sequence":"additional","affiliation":[{"name":"Division of Global HIV and Tuberculosis (DGHT) U.S. Centers for Disease Control and Prevention  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamina M.","family":"Gorbach","sequence":"additional","affiliation":[{"name":"Department of Epidemiology UCLA Fielding School of Public Health  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le Minh","family":"Giang","sequence":"additional","affiliation":[{"name":"Hanoi Medical University  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"volume-title":"Pre\u2010exposure prophylaxis (PrEP)","year":"2018","author":"Sanchez JD","key":"e_1_2_12_2_1"},{"volume-title":"What's the 2+1+1? 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