{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:11:08Z","timestamp":1784247068172,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>New pre\u2010exposure prophylaxis (PrEP) options, including event\u2010driven and long\u2010acting injectable, may enhance HIV prevention strategies among adolescents and youth. This study examined awareness and intention to use event\u2010driven and long\u2010acting injectable PrEP, along with associated factors, among adolescent and young men who have sex with men and transgender women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study was conducted between December 2020 and February 2022 among men who have sex with men and young transgender women aged 15\u201320 years, who participated in a daily oral PrEP cohort study in Salvador and S\u00e3o Paulo, Brazil. Binomial logistic regression models analysed factors associated with the intention to use event\u2010driven and long\u2010acting injectable PrEP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1221 participants were enrolled in the cohort at the time of this analysis, with 597 responding to the survey. Awareness of event\u2010driven and long\u2010acting injectable PrEP was reported by 15.3% and 18.0% of participants, respectively. Intention to use event\u2010driven PrEP was reported by 56.4% of participants, while 81.5% expressed intention to use long\u2010acting injectable PrEP. Participants with lower and moderate adherence to daily oral PrEP were more likely to intend to use event\u2010driven PrEP (OR = 1.79; 95% CI: 1.04\u20133.08), whereas those who reported always or often using condoms in insertive anal sex with steady or casual partners were less likely to intend to use event\u2010driven PrEP (OR = 0.37; 95% CI: 0.15\u20130.90). For long\u2010acting injectable PrEP, participants with middle (OR = 1.93; 95% CI: 1.05\u20133.53) or low socio\u2010economic status (OR = 3.13; 95% CI: 1.30\u20137.51) and those reporting three or more casual partners in the past 3 months (OR = 2.25; 95% CI: 1.30\u20133.89) were more likely to intend to use long\u2010acting injectable PrEP. Conversely, participants who had never used daily oral PrEP were less likely to intend to use long\u2010acting injectable PrEP (OR = 0.31; 95% CI: 0.11\u20130.92).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adolescents and young people in Brazil demonstrated a stronger preference for long\u2010acting injectable over event\u2010driven PrEP, with sexual behaviour patterns significantly influencing choices. Expanding prevention options may enhance PrEP uptake and adherence, improving HIV prevention strategies among adolescents and young adults.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jia2.26479","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T07:27:15Z","timestamp":1751441235000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Awareness and intention to use event\u2010driven and long\u2010acting injectable pre\u2010exposure prophylaxis among adolescent and young men who have sex with men and transgender women in Brazil: a cross\u2010sectional study"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3752-0782","authenticated-orcid":false,"given":"Laio","family":"Magno","sequence":"first","affiliation":[{"name":"Departamento de Ci\u00eancias da Vida Universidade do Estado da Bahia  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4137-9809","authenticated-orcid":false,"given":"Beo Oliveira","family":"Leite","sequence":"additional","affiliation":[{"name":"Instituto de Sa\u00fade Coletiva Universidade Federal da Bahia  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5157-0597","authenticated-orcid":false,"given":"Alexandre","family":"Grangeiro","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9173-6918","authenticated-orcid":false,"given":"Lorenza","family":"Dezanet","sequence":"additional","affiliation":[{"name":"Instituto de Sa\u00fade Coletiva Universidade Federal da Bahia  Salvador Brazil"},{"name":"Faculdade de Medicina Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4067-7860","authenticated-orcid":false,"given":"Fabiane","family":"Soares","sequence":"additional","affiliation":[{"name":"Instituto de Sa\u00fade Coletiva Universidade Federal da Bahia  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1675-2146","authenticated-orcid":false,"given":"In\u00eas","family":"Dourado","sequence":"additional","affiliation":[{"name":"Instituto de Sa\u00fade Coletiva Universidade Federal da Bahia  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461\u2010021\u201003180\u20105"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010017\u20102795\u20109"},{"key":"e_1_2_11_4_1","article-title":"Secretaria de Vigil\u00e2ncia em Sa\u00fade\u2014Departamento de DST AeHV","author":"Brasil. 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