{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:55:33Z","timestamp":1792569333680,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010877","name":"ViiV Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>HIV guidelines recommend switching from a three\u2010drug regimen (3DR) to dolutegravir + lamivudine (DTG+3TC) for eligible individuals. This retrospective national cohort study used Swedish InfCareHIV registry data to evaluate long\u2010term outcomes of adults with HIV RNA &lt;50 copies\/ml who switched to DTG+3TC or a guideline\u2010recommended 3DR between July 2019 and May 2023 in routine clinical care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Demographic and clinical data were obtained from InfCareHIV at baseline, 6, 12, 24, 36 and 42 months post\u2010switch. The primary endpoint was virologic failure (VF) rates at each time point; secondary endpoints included VF rates in prespecified subgroups, time to VF, and incidence of viral blips and treatment\u2010emergent resistance. Generalized estimating equations modelling was used to assess the effects of clinical predictors on VF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1125 individuals (46%) switched to DTG+3TC, and 1336 (54%) switched to 3DR. Adjusted VF rates post\u2010switch were 0.1\u20132.9% in the DTG+3TC group and 0.3\u20132.2% in the 3DR group in the intent\u2010to\u2010treat analysis (0\u20130.4% and 0.3\u20132.3% in the on\u2010treatment [OT] analysis, respectively). In the OT set, the odds of VF were significantly lower for DTG+3TC versus 3DR at 24, 36 and 42 months (\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.001). Treatment\u2010emergent resistance rates were low in both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this long\u2010term, real\u2010world, national cohort, switching to DTG+3TC was associated with low rates of VF and antiretroviral therapy resistance, indicating that eligible individuals can be switched to DTG+3TC without increased risk of VF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jia2.70054","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T02:58:25Z","timestamp":1773025105000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative effectiveness of dolutegravir + lamivudine versus three\u2010drug regimens in Swedish clinical practice: a nationwide study"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6966-7485","authenticated-orcid":false,"given":"Erik","family":"S\u00f6rstedt","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Institute of Biomedicine University of Gothenburg Sahlgrenska Academy  Gothenburg Sweden"},{"name":"Department of Infectious Diseases Region V\u00e4stra G\u00f6taland Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3009-4936","authenticated-orcid":false,"given":"George","family":"Nduva","sequence":"additional","affiliation":[{"name":"GSK Sweden  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"M\u00e5nsson","sequence":"additional","affiliation":[{"name":"Clinical Infection Medicine Department of Translational Medicine Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5sa","family":"Mellgren","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Institute of Biomedicine University of Gothenburg Sahlgrenska Academy  Gothenburg Sweden"},{"name":"Department of Infectious Diseases Region V\u00e4stra G\u00f6taland Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Repits","sequence":"additional","affiliation":[{"name":"GSK Sweden  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Fernvik","sequence":"additional","affiliation":[{"name":"ViiV Healthcare  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Stubbs","sequence":"additional","affiliation":[{"name":"ViiV Healthcare  London 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