{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:31:03Z","timestamp":1792416663345,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Despite oral HIV pre\u2010exposure prophylaxis (PrEP) effectiveness, uptake and adherence remains a challenge. Newer HIV prevention technologies, including long\u2010acting injectable cabotegravir (CAB\u2010LA), are promising for addressing known barriers to oral PrEP uptake and adherence, yet research remains limited on experiences with CAB\u2010LA among at\u2010risk adults in community settings. This descriptive qualitative study explored experiences with CAB\u2010LA among adults participating in the SEARCH Dynamic Choice HIV Prevention (DCP) trial in rural Kenya and Uganda, which evaluated HIV prevention uptake through a structured, person\u2010centred DCP model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted in\u2010depth semi\u2010structured interviews in July\u2212October 2023 with a purposively selected sample of 47 DCP trial participants who initiated CAB\u2010LA and had at least two injections. Interviews explored participants\u2019 reasons for choosing CAB\u2010LA and their experiences with the method. We also included 10 participants who subsequently discontinued CAB\u2010LA or switched to another method. Data were analysed using inductive coding, memoing and framework analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The 47 participants ranged from 20 to 59 years of age; 13 were men and 34 were women. Participants were enthusiastic about CAB\u2010LA. They perceived it as novel, efficacious and advantageous relative to oral daily PrEP, which had been hindered by stigma, interruptions due to work, family visits and travel, side effects, and pill attributes (size and smell). Two major advantages of CAB\u2010LA over PrEP were improved protection from HIV stigma and from HIV acquisition due to easier adherence. Participants felt CAB\u2010LA was clearly distinguishable from antiretroviral therapy and would not mark them (mistakenly) as living with HIV; among women, clandestine use to guard against stigma from family members was more achievable compared to oral PrEP. Appointments for injections were rare enough (monthly, then bimonthly) that they could be kept, especially with reminders from providers, although for some, unpredictable work and travel schedules hindered their uptake of CAB\u2010LA. Participants cited injection\u2010site pain as the main drawback.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CAB\u2010LA overcame several known barriers to HIV prevention uptake and adherence for women and men. In contexts of continued HIV\u2010related stigma, CAB\u2010LA met some participants\u2019 preferences for a product that permitted prevention to be visibly distinguishable from treatment, enabling HIV prevention uptake to feel safer. Moreover, adherence was more easily achieved with CAB\u2010LA compared to PrEP, boosting confidence in prevention efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jia2.70059","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T06:45:23Z","timestamp":1764053123000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Early experiences with usage of long\u2010acting injectable cabotegravir among adults in rural Ugandan and Kenyan communities: qualitative research from the SEARCH \u201cDynamic Choice HIV Prevention\u201d intervention trials"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5615-1164","authenticated-orcid":false,"given":"Carol S.","family":"Camlin","sequence":"first","affiliation":[{"name":"Division of Prevention Science Department of Medicine, University of California, San Francisco (UCSF)  San Francisco California USA"},{"name":"Obstetrics, Gynecology &amp; Reproductive Sciences University of California, San Francisco (UCSF)  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjeline","family":"Onyango","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute (KEMRI)  Kisumu Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Johnson\u2010Peretz","sequence":"additional","affiliation":[{"name":"Obstetrics, Gynecology &amp; Reproductive Sciences University of California, San Francisco (UCSF)  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Akatukwasa","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Titus O.","family":"Arunga","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute (KEMRI)  Kisumu Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3817-4386","authenticated-orcid":false,"given":"Lawrence","family":"Owino","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute (KEMRI)  Kisumu Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick","family":"Atwine","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambrose","family":"Byamukama","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Mutabazi","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura B.","family":"Balzer","sequence":"additional","affiliation":[{"name":"Berkeley, Biostatistics, Epidemiology, and Computational Precision Health University of California  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maggie","family":"Czarnogorski","sequence":"additional","affiliation":[{"name":"ViiV Healthcare  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elijah","family":"Kakande","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Sunday","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5860-8081","authenticated-orcid":false,"given":"Gabriel","family":"Chamie","sequence":"additional","affiliation":[{"name":"Division of HIV, Infectious Diseases &amp; Global Medicine Department of Medicine, University of California, San Francisco (UCSF)  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0324-4006","authenticated-orcid":false,"given":"James","family":"Ayieko","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute (KEMRI)  Kisumu Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Petersen","sequence":"additional","affiliation":[{"name":"Berkeley, Biostatistics, Epidemiology, and Computational Precision Health University of California  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Sutter","sequence":"additional","affiliation":[{"name":"Division of HIV, Infectious Diseases &amp; Global Medicine Department of Medicine, University of California, San Francisco (UCSF)  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses R.","family":"Kamya","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration  Kampala Uganda"},{"name":"Department of Medicine Makerere University College of Health Sciences  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0761-3136","authenticated-orcid":false,"given":"Diane V.","family":"Havlir","sequence":"additional","affiliation":[{"name":"Division of HIV, Infectious Diseases &amp; 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