{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T06:46:59Z","timestamp":1784011619930,"version":"3.55.0"},"reference-count":65,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100032626","name":"Unitaid","doi-asserted-by":"publisher","award":["609002"],"award-info":[{"award-number":["609002"]}],"id":[{"id":"10.13039\/100032626","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Advanced HIV disease (AHD) remains a leading cause of mortality in Latin America and the Caribbean (LAC), driven by late diagnosis, treatment gaps and structural barriers, particularly among key populations and children. Persistent disparities in healthcare access, stigma, and limited health system capacity highlight the need for targeted research to improve AHD outcomes in the region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The modified Delphi process to prioritize AHD research questions in LAC was conducted between August and November 2024. Systematic reviews, expert consultations and two Delphi rounds involving 74 and 69 participants from 17 LAC countries assessed questions based on public health relevance, feasibility and equity. A subsequent in\u2010person workshop with 24 experts refined and validated the results, organizing the prioritized questions into short\u2010, medium\u2010 and long\u2010term priorities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy\u2010seven high\u2010priority research questions were identified, 60 focused on adults and 17 on children. These questions centred on opportunistic infections (OIs), HIV\u2010related cancers and health system interventions. Tuberculosis was the most frequently addressed OI (44% of OI\u2010related questions), followed by cryptococcosis, histoplasmosis and HIV\u2010related malignancies. Short\u2010term priorities included interventions to reduce late diagnosis, improve retention in care and strengthen health systems, particularly for vulnerable populations such as children, pregnant women and incarcerated individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study presents a comprehensive research agenda for AHD in LAC, emphasizing interventions to address OIs, strengthen the health system and support at\u2010risk populations. The prioritized questions provide a roadmap for researchers, policymakers and funders to allocate resources effectively, ultimately improving AHD outcomes and reducing HIV\u2010related mortality. Strengthening regional collaboration and political commitment will be critical to translating research into actionable policies and interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jia2.70074","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T18:00:17Z","timestamp":1768586417000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Research priorities for advanced HIV disease in Latin America and the Caribbean region: a modified Delphi study"],"prefix":"10.1002","volume":"29","author":[{"given":"Evelina","family":"Chapman","sequence":"first","affiliation":[{"name":"Department of Communicable Diseases Prevention, Control and Elimination, Pan American Health Organization  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Sued","sequence":"additional","affiliation":[{"name":"Department of Communicable Diseases Prevention, Control and Elimination, Pan American Health Organization  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge O. Maia","family":"Barreto","sequence":"additional","affiliation":[{"name":"Department of Communicable Diseases Prevention, Control and Elimination, Pan American Health Organization  Washington DC USA"},{"name":"Oswaldo Cruz Foundation  Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia P.","family":"Cortes","sequence":"additional","affiliation":[{"name":"Center for HIV AIDS Integral Research\u2010Chair Facultad de Medicina Universidad de Chile and Hospital Clinico San Borja Arriar\u00e1n  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda Crabtree","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Departamento de Infectolog\u00eda, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 E.","family":"Vidal","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Extens\u00e3o ao Atendimento de Pacientes HIV\/Aids (SEAP), Departamento de Infectologia e Medicina Tropical Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Departamento de Neurologia Instituto de Infectologia Em\u00edlio Ribas  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Camiro\u2010Z\u00fa\u00f1iga","sequence":"additional","affiliation":[{"name":"Department of Communicable Diseases Prevention, Control and Elimination, Pan American Health Organization  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freddy","family":"Perez","sequence":"additional","affiliation":[{"name":"Department of Communicable Diseases Prevention, Control and Elimination, Pan American Health Organization  Washington DC USA"},{"name":"Federal University of Health Sciences of Porto Alegre (UFCSPA)  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"UNAIDS.AIDS crisis and the power to transform: UNAIDS Global AIDS Update 2025.Geneva:Joint United Nations Programme on HIV\/AIDS;2025. Available from:https:\/\/www.unaids.org\/sites\/default\/files\/2025\u201007\/2025\u2010global\u2010aids\u2010update\u2010JC3153_en.pdf."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwz252"},{"key":"e_1_2_11_4_1","unstructured":"WHO. Consolidated guidelines on HIV prevention testing treatment service delivery and monitoring: recommendations for a public health approach.World Health Organization;2025. Available from:https:\/\/www.who.int\/publications\/i\/item\/9789240031593."},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000003560"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25468"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/20499361231164030"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lana.2021.100024"},{"key":"e_1_2_11_9_1","volume-title":"The world health report 2013: research for universal health coverage","author":"WHO","year":"2025"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr426"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cesm.70007"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/qai.0000000000001743"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(02)11775\u20102"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461\u2010018\u20102342\u20108"},{"key":"e_1_2_11_15_1","volume-title":"A systematic approach for undertaking a research priority\u2010setting exercise","author":"WHO","year":"2020"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010156\u20105\u2010201203060\u201000009"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.06.009"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2012.07.009"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.5662\/wjm.v11.i4.116"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12790"},{"key":"e_1_2_11_21_1","unstructured":"WHO.The advanced HIV disease research landscape.World Health Organization;2024. Available from:https:\/\/iris.who.int\/bitstream\/handle\/10665\/376040\/9789240089020\u2010eng.pdf?sequence=1."},{"issue":"1","key":"e_1_2_11_22_1","first-page":"5","article-title":"Towards a Prague definition of grey literature","volume":"7","author":"Sch\u00f6pfel J","year":"2011","journal-title":"Grey J"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214\u2010109X(24)00266\u20103"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010024\u201009257\u20105"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof10100695"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(15)00137-X"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2022.06.041"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1032"},{"key":"e_1_2_11_29_1","volume-title":"Global tuberculosis report 2024","author":"WHO","year":"2024"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(23)00251-6"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/qad.0000000000003321"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix1143"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof7040268"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1473\u20103099(22)00499\u20106"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0010960"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25658"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.12.18.24319250"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.14070"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010022\u201007311\u20108"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.26633\/rpsp.2021.47"},{"key":"e_1_2_11_41_1","unstructured":"BertoniAPSRF Ordo\u00f1ezJA AnderleRV Scaff PintoPF ChivardiC MoncayoAL et\u00a0al.Mitigating new AIDS cases through poverty elimination by 2030: a Latin American perspective. Presented poster in the 25th International AIDS Conference on HIV Science;2024 Munchen Germany. Available from:https:\/\/plus.iasociety.org\/sites\/default\/files\/2024\u201009\/e\u2010poster_139.pdf."},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20103018(19)30402\u20103"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgph.0001861"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13487"},{"key":"e_1_2_11_45_1","volume-title":"WHO expands in vitro diagnostics (IVD) prequalification to support tuberculosis diagnosis","author":"World Health Organization (WHO)","year":"2025"},{"key":"e_1_2_11_46_1","unstructured":"Pan American Health Organization.PAHO strategic fund.2025. Available from:https:\/\/www.paho.org\/en\/paho\u2010strategic\u2010fund."},{"key":"e_1_2_11_47_1","volume-title":"The Global Advanced HIV Disease Toolkit","author":"International AIDS Society (IAS)","year":"2025"},{"key":"e_1_2_11_48_1","unstructured":"FHI 360. Package of services and interventions for advanced HIV disease: a community guide. Durham NC: FHI 360;2024. Available from:https:\/\/www.fhi360.org\/wp\u2010content\/uploads\/2024\/01\/resource\u2010advanced\u2010hiv\u2010community\u2010guide.pdf."},{"key":"e_1_2_11_49_1","doi-asserted-by":"crossref","unstructured":"PasqualottoAC SuedO ReisN SilvaLR SoaresR GodoyCS et\u00a0al.Impact of the introduction of a package of care involving early detection of opportunistic infections in people living with HIV\/AIDS: a Pan American Health Organization (PAHO) initiative in Brazil.2025","DOI":"10.2139\/ssrn.4794464"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2025.09.002"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(24)00042-9"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2025.06.013"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472\u20106963\u20109\u201043"},{"key":"e_1_2_11_54_1","volume-title":"Committee on the NIH Research Priority\u2010Setting Process. Scientific Opportunities and Public Needs: Improving Priority Setting and Public Input at the National Institutes of Health","author":"Institute of Medicine","year":"1998"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaf267"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.26633\/RPSP.2024.84"},{"key":"e_1_2_11_57_1","unstructured":"WexlerA KatesJ LiefE.Donor government funding for HIV in low\u2010 and middle\u2010income countries in 2024.Joint United Nations Programme on HIV\/AIDS (UNAIDS);2025. Available from:https:\/\/www.kff.org\/global\u2010health\u2010policy\/donor\u2010government\u2010funding\u2010for\u2010hiv\u2010in\u2010low\u2010and\u2010middle\u2010income\u2010countries\u2010in\u20102024\/."},{"key":"e_1_2_11_58_1","volume-title":"Tuberculosis and malaria. Latin America and the Caribbean\u2014impact report","author":"The Global Fund to Fight AIDS","year":"2024"},{"key":"e_1_2_11_59_1","volume-title":"Tuberculosis and malaria. Core 2025 investment case report","author":"The Global Fund to Fight AIDS","year":"2024"},{"key":"e_1_2_11_60_1","volume-title":"Investment Case 2023\u20132027","author":"UNITAID","year":"2023"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)31070\u20105"},{"key":"e_1_2_11_62_1","unstructured":"International Development Research Centre. About IDRC. International Development Research Centre [accessed December 21 2025]; Available from:https:\/\/www.idrc\u2010crdi.ca\/en\/about\u2010idrc."},{"key":"e_1_2_11_63_1","volume-title":"HIV Market Report","author":"Clinton Health Access Initiative","year":"2024"},{"key":"e_1_2_11_64_1","volume-title":"Tecnolog\u00eda e Innovaci\u00f3n 2021\u20132024","author":"Programa Especial de Ciencia","year":"2024"},{"key":"e_1_2_11_65_1","unstructured":"Brasil. Minist\u00e9rio da Ci\u00eancia. Tecnologia e Inova\u00e7\u00f5es. Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq). CNPq to invest BRL 215 million in international scientific cooperation scholarships projects.Bras\u00edlia:MCTI;2024. Available from:https:\/\/www.gov.br\/secom\/en\/latest\u2010news\/2024\/06\/cnpq\u2010to\u2010invest\u2010brl\u2010215\u2010million\u2010in\u2010international\u2010scientific\u2010cooperation\u2010scholarships\u2010projects"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp2313777"}],"container-title":["Journal of the International AIDS Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jia2.70074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jia2.70074","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jia2.70074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T04:11:33Z","timestamp":1769227893000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jia2.70074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":65,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/jia2.70074"],"URL":"https:\/\/doi.org\/10.1002\/jia2.70074","archive":["Portico"],"relation":{},"ISSN":["1758-2652","1758-2652"],"issn-type":[{"value":"1758-2652","type":"print"},{"value":"1758-2652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-08-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70074"}}