{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:02:19Z","timestamp":1791874939067,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The global HIV response, once a model of progress and innovation, faces a profound moment. Despite four decades of pivotal scientific and programmatic advances\u2014most notably in antiretroviral therapy (ART) and pre\u2010exposure prophylaxis (PrEP)\u2014the world remains off track to meet the 2025 and 2030 targets for ending AIDS as a public health threat. New acquisitions and AIDS\u2010related deaths remain unacceptably high, particularly among key populations and in low\u2010 and middle\u2010income countries. The abrupt U.S. funding reversals in 2025 have severely disrupted support for HIV efforts. Cuts to U.S. and international institutions have compromised HIV prevention, treatment and surveillance systems worldwide, and may already have begun reversing two decades of progress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>To avert this crisis, the HIV and public health community, together with governments and global funders, must urgently invest in scaling long\u2010acting treatment and prevention tools, rebuild disaggregated data systems and strengthen implementation science rooted in community\u2010led approaches. Digital health technologies offer promise to enhance service delivery, surveillance, monitoring and evaluation, especially in resource\u2010constrained settings, but demand ethical governance and infrastructure investment. The global research ecosystem must become more evenly distributed and inclusive, with a shift towards country\u2010led partnerships, national data sovereignty and regional co\u2010operation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Looking to 2030 and beyond, the strategy to end HIV should include expanded access to long\u2010acting ART and PrEP, sustained investments in HIV vaccine and cure research, and robust monitoring and evaluation systems. Achieving epidemic control\u2014and ultimately ending the HIV pandemic\u2014will require not only biomedical tools but also political will, community leadership and equitable financing. The lessons of the past underscore that sustained progress is possible, but only if we meet this moment with urgency, imagination and solidarity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jia2.70077","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T17:18:40Z","timestamp":1771607920000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The HIV\/AIDS response as we knew it is over: Where do we go from here?"],"prefix":"10.1002","volume":"29","author":[{"given":"Chris","family":"Beyrer","sequence":"first","affiliation":[{"name":"Duke Global Health Institute  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jirair","family":"Ratevosian","sequence":"additional","affiliation":[{"name":"Duke Global Health Institute  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Carpino","sequence":"additional","affiliation":[{"name":"Duke Global Health Institute  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora E.","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"UNC Gillings School of Global Public Health  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huub C.","family":"Gelderblom","sequence":"additional","affiliation":[{"name":"Fred Hutch Cancer Center  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick S.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Rollins School of Public Health Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve G.","family":"Deeks","sequence":"additional","affiliation":[{"name":"University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenda","family":"Gray","sequence":"additional","affiliation":[{"name":"South African Medical Research Council  Cape Town South Africa"},{"name":"Infectious Disease and Oncology Research Institute University of Witwatersrand  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00452-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(24)00098-5"},{"key":"e_1_2_9_4_1","unstructured":"New UNAIDS report shows AIDS pandemic can be ended by 2030 but only if leaders boost resources and protect human rights now [Internet]. 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