{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:22:00Z","timestamp":1791292920029,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100013074","name":"Lake Forest College","doi-asserted-by":"publisher","award":["K23 AG0844"],"award-info":[{"award-number":["K23 AG0844"]}],"id":[{"id":"10.13039\/100013074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013074","name":"Lake Forest College","doi-asserted-by":"publisher","award":["R01 MH123396 (KAC)"],"award-info":[{"award-number":["R01 MH123396 (KAC)"]}],"id":[{"id":"10.13039\/100013074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Long\u2010acting injectable (LAI) cabotegravir\/rilpivirine (CAB\/RPV) represents a breakthrough in HIV treatment. However, understanding how to optimize real\u2010world service delivery and user experiences among people with HIV (PWH) remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between August 2022 and December 2024, we conducted semi\u2010structured interviews with PWH at four academic Ryan White\u2010funded HIV clinics in Atlanta, Chicago and San Francisco. Eligibility criteria were current LAI\u2010CAB\/RPV use with \u22653 injections or having discontinued. Interviews were analysed using thematic analysis grounded in descriptive phenomenology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 69 participants, 48 of whom were receiving LAI\u2010CAB\/RPV and 21 who had discontinued, we identified three themes that highlighted opportunities to enhance patient\u2010centred service delivery of LAI\u2010CAB\/RPV: (1) enhancing knowledge and self\u2010efficacy in using oral antiretroviral therapy (ART) in cases of missed or late injections; (2) improving patient comfort and confidence, particularly regarding injection anxiety, pain management and blood draws; (3) attending to the potential evolution of patient\u2010provider relationships, as in most cases injection visits outnumber primary care visits. In addition, PWH may experience depressive feelings upon discontinuation, even if they view it as the right decision.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Optimizing the LAI\u2010CAB\/RPV patient journey requires developing a specialized support framework that is distinct from oral ART protocols. This new treatment modality requires a tailored approach that addresses unique challenges, including facilitating candid discussions about adherence contingencies, managing the physical and psychological aspects of injection experiences, ensuring meaningful and consistent provider relationships amid changing care patterns and providing enhanced support during treatment transitions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jia2.70082","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T04:45:23Z","timestamp":1770957923000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Optimizing the patient journey: Insights from early implementation of long\u2010acting cabotegravir and rilpivirine in four urban Ryan White\u2010funded clinics in the United States"],"prefix":"10.1002","volume":"29","author":[{"given":"Xavier A.","family":"Erguera","sequence":"first","affiliation":[{"name":"Department of Medicine University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mollie B.","family":"Smith","sequence":"additional","affiliation":[{"name":"University of Massachusetts Chan Medical School  Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyasha","family":"Pareek","sequence":"additional","affiliation":[{"name":"Department of Medicine Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Dawdani","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaylin V.","family":"Dance","sequence":"additional","affiliation":[{"name":"Ponce de Leon Center Grady Health System  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan S.","family":"Walker","sequence":"additional","affiliation":[{"name":"Columbia University Vagelos College of Physicians and Surgeons  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Grochowski","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Oskarsson","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Hickey","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California San Francisco  San Francisco California 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California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Colasanti","sequence":"additional","affiliation":[{"name":"Department of Medicine Emory University  Atlanta Georgia USA"},{"name":"Ponce de Leon Center Grady Health System  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren F.","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Medicine Emory University  Atlanta Georgia USA"},{"name":"Ponce de Leon Center Grady Health System  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moira C.","family":"McNulty","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly A.","family":"Koester","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina A.","family":"Christopoulos","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"RanaA BaoY ZhengL SieczkarskiS LakeJ FichtenbaumC.Long\u2010acting injectable CAB\/RPV is superior to oral ART in PWH with adherence challenges: ACTG A5359.Presented at: Conference on Retroviruses and Opportunistic Infections;2024 Mar 3;Denver CO."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/23259582211009011"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/AID.2020.0126"},{"key":"e_1_2_11_5_1","volume-title":"Cabenuva [package 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