{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:44:04Z","timestamp":1779378244175,"version":"3.53.1"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017420","name":"Penta Foundation UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017420","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The development of approaches and interventions to achieve HIV remission continues to accelerate. Children living with HIV who started antiretroviral therapy (ART) at a young age and sustain viral suppression are an ideal clinical trial population. Trials may require analytic treatment interruptions (ATIs). Paediatric trials depend on the willingness of guardians to consent to child participation, yet there are few data about guardian willingness or attitudes. Here, we investigated the opinions of guardians of children likely to be eligible for ATI trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Children and youth who started ART \u2264 3 months of age, and who remained well\u2010controlled on ART older than 7 years, were recruited in South Africa, Mozambique, Uganda, Mali and Thailand. A survey was conducted among guardians of these paediatric participants. The survey utilized a vignette describing a trial with ATI and assessed attitudes and intentions (measured on 7\u2010point scales) of the guardians regarding their children's participation in a hypothetical trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Guardians of 99 children were recruited. Guardians\u2019 median age was 45 years (range 24\u201373) and most (89.9%) were female. The median age of the child or youth with HIV was 13.2 years (range 7\u201318.5 years). Most respondents endorsed a positive intention to enrol their child in a future HIV remission trial (mean 6.5 [SD:1.3] on a 7\u2010point scale), with significant variation across the sites (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0024). Most respondents strongly endorsed a range of trial benefits, including better future HIV treatments (93.8%) and access to better care (88.0%). Some endorsed concern about the trial burden to themselves (33.3%) and the child (35.4%). Almost half strongly believed that the trial would result in the child no longer needing ART (48%) and the child being cured of HIV (46.5%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Across multiple countries, guardians of children and youth who were treated early were positive about participation in trials with ATI. Only a third expressed some concern about trial burden, while almost half had unrealistic expectations about potential benefits. Recruitment into trials involving ATI will need to include effective communication strategies to ensure that participants and caregivers are adequately informed about burden, potential risks and the likelihood of personal benefit.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jia2.70084","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T09:20:04Z","timestamp":1770715204000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intentions and attitudes of caregivers towards enrolment of their children and adolescents living with HIV into remission trials involving analytic treatment interruption"],"prefix":"10.1002","volume":"29","author":[{"given":"Holly L.","family":"Peay","sequence":"first","affiliation":[{"name":"RTI International Research Triangle Park  Durham North Carolina USA"},{"name":"Faegre Drinker Consulting  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kennedy","family":"Otwombe","sequence":"additional","affiliation":[{"name":"Perinatal HIV Research Unit, Chris Hani Baragwanath Academic Hospital; and School of Public Health, Faculty of Health Sciences University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun","family":"Barnabas","sequence":"additional","affiliation":[{"name":"FAMCRU, Tygerberg Academic Hospital Stellenbosch University  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Barrios\u2010Tascon","sequence":"additional","affiliation":[{"name":"Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Lain","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Ariel Glaser contra o SIDA Pedi\u00e1trico  Maputo Mozambique"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tacilta","family":"Nhampossa","sequence":"additional","affiliation":[{"name":"Manhi\u00e7a Health Research Center  Manhi\u00e7a Mozambique"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Rutebarika","sequence":"additional","affiliation":[{"name":"Joint Clinical Research Centre  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thidarat","family":"Jupimai","sequence":"additional","affiliation":[{"name":"Center of Excellence for Pediatric Infectious Diseases and Vaccines, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moherndran","family":"Archary","sequence":"additional","affiliation":[{"name":"Africa Health Research Institute  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almoustapha\u2010Issiaka","family":"Maiga","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Gabriel Tour\u00e9 University of Sciences Techniques and Technologies of Bamako  Bamako Mali"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avy","family":"Violari","sequence":"additional","affiliation":[{"name":"Perinatal HIV Research Unit, Chris Hani Baragwanath Academic Hospital; and School of Public Health, Faculty of Health Sciences University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moira J.","family":"Spyer","sequence":"additional","affiliation":[{"name":"UCL Great Ormond Street Institute of Child Health  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavidha","family":"Reddy","sequence":"additional","affiliation":[{"name":"Africa Health Research Institute  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Palma","sequence":"additional","affiliation":[{"name":"Research Unit of Clinical Immunology and Vaccinology Bambino Ges\u00f9 Children's Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savita","family":"Pahwa","sequence":"additional","affiliation":[{"name":"University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Lichterfeld","sequence":"additional","affiliation":[{"name":"Ragon Institute Harvard University  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Cotton","sequence":"additional","affiliation":[{"name":"FAMCRU, Tygerberg Academic Hospital Stellenbosch University  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01590-5"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002203"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2055-6640(20)30240-5"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(24)00157-7"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2023.113589"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12910-025-01225-1"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-023-04095-z"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/25787489.2023.2243046"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/25787489.2025.2455917"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2025.0002"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0749-5978(91)90020-T"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/inthealth\/ihaa067"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25260"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2023-012966"},{"key":"e_1_2_11_16_1","unstructured":"2nd Consensus Workshop on Analytical Treatment Interruption in HIV Cure Trials.Nairobi Kenya:Co\u2010hosted Sub\u2010Saharan African Network of TB\/HIV Excellence (SANTHE) and the US Military HIV Research Program (MHRP);2024."},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/15562646231193949"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12981-021-00337-z"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2021.2017397"}],"container-title":["Journal of the International AIDS Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jia2.70084","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jia2.70084","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jia2.70084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:29:57Z","timestamp":1772965797000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jia2.70084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/jia2.70084"],"URL":"https:\/\/doi.org\/10.1002\/jia2.70084","archive":["Portico"],"relation":{},"ISSN":["1758-2652","1758-2652"],"issn-type":[{"value":"1758-2652","type":"print"},{"value":"1758-2652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-10-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70084"}}