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Despite the effectiveness of pre\u2010exposure (PrEP) and post\u2010exposure prophylaxis (PEP), barriers to access, initiation and adherence persist. Pharmacists, as accessible healthcare providers with medication expertise, are increasingly involved in HIV prevention. However, the scope and impact of pharmacist\u2010led prophylaxis services have not been comprehensively synthesized. This study aimed to map and characterize the existing evidence on pharmacists\u2019 services, interventions and outcomes in HIV prophylaxis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A scoping review was conducted with searches in Medline (PubMed), Embase, Scopus and LILACS, supplemented by grey literature (Google Scholar) until May 2025. Eligible studies included original research describing pharmacist\u2010led clinical activities or interventions related to HIV prophylaxis. Two independent reviewers conducted study selection and data extraction. Pharmacists\u2019 roles were categorized based on the International Pharmaceutical Federation (FIP) and the Descriptive Elements of Pharmacist Intervention Characterization Tool (DEPICT) Version 2. The impacts of pharmacists on outcomes of care were categorized considering economic, clinical, humanistic and process\u2010related outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Out of 2736 records retrieved from searches, 26 studies published between 2014 and 2025 were included, which were conducted predominantly in the United States (\n                      <jats:italic>n<\/jats:italic>\n                      = 21). Pharmacists commonly performed direct patient care (e.g. patient counselling, PrEP\/PEP prescribing, adherence monitoring, laboratory tests ordering), facilitated medication access and collaborated with other healthcare professionals via different communication methods (face\u2010to\u2010face, telephone, written, videoconference), especially in primary care and community pharmacies. Pharmacists\u2019 autonomy to prescribe and order laboratory tests was observed in several studies under both independent and collaborative practice models. Twenty studies reported positive process outcomes, such as increased PrEP initiation, adherence and retention, while fewer assessed clinical (\n                      <jats:italic>n<\/jats:italic>\n                      = 8), economic (\n                      <jats:italic>n<\/jats:italic>\n                      = 2) or humanistic (\n                      <jats:italic>n<\/jats:italic>\n                      = 1) outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Expanding pharmacist\u2010led services, particularly in underserved regions, represents a promising strategy to improve access, initiation and adherence to HIV prevention. Future research on economic and patient\u2010centred outcomes is needed to inform integration of pharmacists into HIV prevention strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pharmacists play a growing and multifaceted role in HIV prophylaxis across diverse healthcare settings. Evidence supports the expansion of pharmacist\u2010led models through enabling legislation, reimbursement policies and interprofessional collaboration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jia2.70090","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:29:45Z","timestamp":1772965785000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Role of pharmacists in HIV prophylaxis: a scoping review of pharmacists\u2019 services, interventions and outcomes"],"prefix":"10.1002","volume":"29","author":[{"given":"Gustavo Magno Baldin","family":"Tiguman","sequence":"first","affiliation":[{"name":"Department of Pharmacy Faculty of Pharmaceutical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Veiga","family":"Barbosa das Dores","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Pharmaceutical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Melo","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Pharmaceutical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"HIV statistics, globally and by WHO region, 2024","author":"World Health Organization","year":"2024"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(24)00212-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01381-8"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001145"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa037"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(23)00238-2"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31065-5"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sapharm.2024.01.006"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-025-13387-0"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-022-01444-1"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/17151635251355277"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-024-00700-5"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-021-03494-4"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.26232"},{"key":"e_1_2_10_16_1","volume-title":"Global situation report on pharmacy 2025: workforce, practice and policy","author":"International Pharmaceutical Federation (FIP)","year":"2025"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/XEB.0000000000000050"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18-0850"},{"key":"e_1_2_10_19_1","volume-title":"Patient safety. 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