{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:44Z","timestamp":1786978004466,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Migrants living with HIV often face high mobility, vulnerability and limited baseline information on HIV\u20101 genotype or treatment history. We aimed to assess the effectiveness and persistence of long\u2010acting injectable cabotegravir and rilpivirine (LAI CAB+RPV) among migrants in Spain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicentre cohort study across 58 Spanish hospitals included virologically suppressed adults switching to CAB+RPV LAI before January 2025. Data collection started in June 2023. Baseline characteristics and outcomes were compared by migrant status, and multivariate Cox proportional hazards regression models were fitted to assess factors associated with virological failure (VF) and discontinuation. Propensity score matching (PSM) by gender, age, known genotype and prior VF was employed to control for confounding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 3135 participants, 951 (30.3%) were migrants, predominantly from Latin America. Median follow\u2010up was 13.8 months (interquartile range 8.91\u201319.1). VF occurred in 0.9% of migrants versus 0.5% of Spanish\u2010born individuals (odds ratio 1.89, 95% confidence interval [CI] 0.69\u20135.03;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.22). In adjusted models, migrant status showed a non\u2010significant trend towards higher VF (adjusted hazard ratio [aHR] 2.16, 95% CI 0.89\u20135.22;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.079). At 12 months, 95.8% of migrants (461\/481) persisted on LAI CAB+RPV treatment versus 98.3% of Spanish\u2010born individuals (1348\/1372) (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.005). Discontinuation due to any adverse event was more frequent in migrants (3.3%\u00a0vs. 1.8%). Migrant status was significantly associated with discontinuation due to both local (aHR 2.63, 95% CI 1.33\u20135.26;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.005) and systemic adverse events (aHR 3.33, 95% CI 1.45\u20137.69,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.005).\n                    <\/jats:p>\n                    <jats:p>\n                      In the PSM cohort (\n                      <jats:italic>n<\/jats:italic>\n                      = 932 per group), migrant status was independently associated with increased risk of VF (aHR 3.51, 95% CI 0.95\u201312.98,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.045) and discontinuation due to systemic adverse events (aHR 2.88, 95% CI 1.01\u20138.17,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.047).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Nearly one\u2010third of participants switching to LAI CAB+RPV were migrants. While VF was rare overall, migrants had a significantly higher risk of treatment discontinuation, partly driven by adverse events. These findings highlight the need for closer monitoring and tailored strategies to optimize persistence with LAI regimens in migrant populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jia2.70106","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T11:34:47Z","timestamp":1776771287000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness and Persistence of Long\u2010Acting Injectable Cabotegravir and Rilpivirine in Migrant Individuals Living With HIV in Spain: Substudy of the RELATIVITY Cohort"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9125-7706","authenticated-orcid":false,"given":"Jara","family":"Llenas\u2010Garc\u00eda","sequence":"first","affiliation":[{"name":"Vega Baja Hospital  Orihuela Spain"},{"name":"Department of Clinical Medicine Miguel Hern\u00e1ndez University  Elche Spain"},{"name":"CIBERINFEC Carlos III Health Institute  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9961-5544","authenticated-orcid":false,"given":"Mar\u00eda del Mar","family":"Arcos Rueda","sequence":"additional","affiliation":[{"name":"La Paz University Hospital IdiPaz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Calder\u00f3n Hernaiz","sequence":"additional","affiliation":[{"name":"Fuenlabrada University Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Pedrero Tom\u00e9","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Para La Investigaci\u00f3n e Innovaci\u00f3n Biom\u00e9dica (FIIB) Del Hospital Universitario Infanta Leonor y Del Hospital Universitario Del Sureste  Madrid Spain"},{"name":"Faculty of Health Sciences International University of La Rioja (UNIR)  Logro\u00f1o Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otilia","family":"Bisbal Pardo","sequence":"additional","affiliation":[{"name":"CIBERINFEC Carlos III Health Institute  Madrid Spain"},{"name":"I+12 Research Institute 12 De Octubre University Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Matarranz","sequence":"additional","affiliation":[{"name":"Infanta Leonor University Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2166-7405","authenticated-orcid":false,"given":"Miguel","family":"Torralba","sequence":"additional","affiliation":[{"name":"Guadalajara University Hospital  Guadalajara Spain"},{"name":"Castilla La Mancha Research Institute (IDISCAM) Alcal\u00e1 University  Alcal\u00e1 de Henares Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Galindo 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