{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:14:45Z","timestamp":1789168485138,"version":"build-2803163510"},"reference-count":82,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Peripartum adolescent girls and young women (AGYW) with HIV have lower viral suppression compared to older women. But the recently introduced dolutegravir\u2010based regimens and psychosocial peer motivation may improve viral control. We assessed viral suppression, adherence, drug exposure and mental health in a cohort of peripartum AGYW with HIV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We present baseline data from an ongoing randomized controlled and observational cohort study. Peripartum (conception to 24 months postpartum) AGYW 15\u2010 to 24\u2010year\u2010old with HIV and\n                      <jats:styled-content>&gt;<\/jats:styled-content>\n                      3 months on tenofovir\u2010based antiretroviral therapy were enrolled between September 2024 and July 2025. Point\u2010of\u2010care viral load and urine tenofovir assays were performed at entry, as well as data on sociodemographic, HIV, treatment and mental health characteristics. Anxiety was assessed using the Generalized Anxiety Disorder\u20107, depression using the Patient Health Questionnaire\u20109, stigma using the Modified HIV Stigma Scale and post\u2010traumatic stress disorder using the Primary Care Post Traumatic Stress Disorder 5 tools.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We enrolled 151 participants. Mean age was 21.1 years. All participants were receiving tenofovir, lamivudine and dolutegravir. Baseline mean viral load was 1133 copies\/mL (cpm); 135 (89.4%) were virally suppressed (viral load\n                      <jats:styled-content>&lt;<\/jats:styled-content>\n                      40 cpm). Mean self\u2010reported adherence over the past 1 month was 97.5%. Tenofovir was detected in 141 (93.4%) participants at baseline. The following were significantly associated baseline with viral suppression (mean [SD]; 95% CI) or (\n                      <jats:italic>n<\/jats:italic>\n                      [%]): higher self\u2010reported adherence (99.5 [1.7]; 99.2\u221299.8,\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.001), detectable urine tenofovir (133 [94.3];\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.001), being married (79 [92.9];\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03), having food security (86 [95.6];\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004) and being financially secure (74 [96.1];\n                      <jats:italic>p<\/jats:italic>\n                      = 0.02). Seven (4.6%) experienced post\u2010traumatic stress disorder, 132 (88.0%) had minimal or no depression; 137 (92.0%) had minimal anxiety and 81 (53.6%) experienced moderate stigma. Participants without detectable tenofovir in urine were 0.05 times less likely to have baseline viral suppression, adjusted odds ratio (95% CI) (0.05 [0.006\u22120.4];\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004). Participants with higher self\u2010reported adherence were 1.3 times more likely to have viral suppression (1.3 [1.1\u22121.6];\n                      <jats:italic>p<\/jats:italic>\n                      = 0.008).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found high viral suppression at enrolment into a cohort study in peripartum AGYW with HIV. Viral suppression was strongly associated with positive urine tenofovir assays and higher self\u2010reported adherence. High mental wellness was demonstrated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jia2.70117","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:12:53Z","timestamp":1781874773000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Baseline Data on Viral Suppression, Treatment Adherence and Mental Health in Peripartum Girls and Young Women With HIV in Zimbabwe"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8754-331X","authenticated-orcid":false,"given":"Tariro D.","family":"Chawana\u2010Mutingwende","sequence":"first","affiliation":[{"name":"University of Zimbabwe Clinical Trials Research Centre  Harare Zimbabwe"},{"name":"Faculty of Medicine and Health Sciences University of Zimbabwe  Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Ngara","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences University of Zimbabwe  Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon\u2010Say","family":"Mudadi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences University of Zimbabwe  Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thelma T.","family":"Tauya","sequence":"additional","affiliation":[{"name":"University of Zimbabwe Clinical Trials Research Centre  Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvelous","family":"Sibanda","sequence":"additional","affiliation":[{"name":"University of Zimbabwe Clinical Trials Research Centre  Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5114-8449","authenticated-orcid":false,"given":"Mercy","family":"Mutambanengwe\u2010Jacob","sequence":"additional","affiliation":[{"name":"University of Zimbabwe Clinical Trials Research Centre  Harare Zimbabwe"},{"name":"Faculty of Medicine and Health Sciences University of Zimbabwe  Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Precious","family":"Andifasi","sequence":"additional","affiliation":[{"name":"Ministry of Health and Child Care  Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette","family":"Malunda","sequence":"additional","affiliation":[{"name":"University of Zimbabwe Clinical Trials Research Centre  Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tinashe","family":"Chidemo","sequence":"additional","affiliation":[{"name":"University of Zimbabwe Clinical Trials Research Centre  Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Mapfunde","sequence":"additional","affiliation":[{"name":"University of Zimbabwe Clinical Trials Research Centre  Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Nyakudya","sequence":"additional","affiliation":[{"name":"University of Zimbabwe Clinical Trials Research Centre  Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Z.","family":"Mufumisi","sequence":"additional","affiliation":[{"name":"University of Zimbabwe Clinical Trials Research Centre  Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thandiwe H.","family":"Chirenda","sequence":"additional","affiliation":[{"name":"University of Zimbabwe Clinical Trials Research Centre  Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Chitambo","sequence":"additional","affiliation":[{"name":"University of Zimbabwe Clinical Trials Research Centre  Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter T. 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