{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T08:02:05Z","timestamp":1784880125095,"version":"3.55.0"},"reference-count":125,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The United States Ending the HIV Epidemic (EHE) initiative was always challenged by structural and implementation barriers to HIV care. On top of that, since 2025, there are additional political and policy barriers that make this goal seem increasingly difficult to achieve. This review identified evidence\u2010based structural, implementation and biomedical interventions available to support each of the EHE pillars and estimated their potential population\u2010level impact, accounting for potential barriers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a targeted literature review of US studies presenting data on efficacy or effectiveness of interventions pertaining to the EHE pillars\u2014prevention, diagnosis, treatment and response\u2014published as of September 2025. We searched interventions included in the US Centers for Disease Control and Prevention HIV Compendium and Response Evidence Brief, all publicly available EHE jurisdictional plans, and the peer\u2010reviewed literature. Potential population impact of an intervention was determined as the product of its effectiveness and scale of delivery. Scale was the product of population reach, provider adoption and structural barriers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 570 studies identified, 57 met the inclusion criteria. We estimated that pre\u2010exposure prophylaxis (PrEP) uptake could increase as much as nearly two\u2010fold (risk ratio [RR]: 1.93, 95% CI: 1.30, 1.96) through pharmacies integrated in primary care clinics. Online HIV self\u2010testing kits were among the most promising interventions to increase testing uptake by two\u2010fold (RR: 1.99, 95% CI: 1.56, 2.57) Finally, a clinic\u2010based education app offering tailored health education could result in a 45% absolute increase (RR: 1.45, 95% CI: 1.29, 1.70) in viral suppression among people living with HIV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Interventions that address barriers to PrEP, HIV testing and adherence to treatment have substantial population\u2010level impact on HIV care outcomes across EHE pillars through changing the context of how care is offered, understood and delivered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jia2.70146","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T06:02:08Z","timestamp":1783663328000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["What Tools Do We Have to End the US HIV Epidemic? A Review of Structural, Biomedical and Implementation Interventions and Their Potential Population Impact"],"prefix":"10.1002","volume":"29","author":[{"given":"Micah","family":"Piske","sequence":"first","affiliation":[{"name":"Centre for Advancing Health Outcomes  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda Carolina","family":"Guerra\u2010Alejos","sequence":"additional","affiliation":[{"name":"Centre for Advancing Health Outcomes  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh Tri","family":"Van","sequence":"additional","affiliation":[{"name":"Centre for Advancing Health Outcomes  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Enns","sequence":"additional","affiliation":[{"name":"Centre for Advancing Health Outcomes  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie G.","family":"Medina","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Simon Fraser University  Burnaby British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zang","sequence":"additional","affiliation":[{"name":"Division of Health Policy and Management, School of Public Health University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy S.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Medicine Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Czarina","family":"Behrends","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos del","family":"Rio","sequence":"additional","affiliation":[{"name":"Department of Medicine Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Enns","sequence":"additional","affiliation":[{"name":"Division of Health Policy and Management, School of Public Health University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvin H.","family":"Geng","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine and Center for Dissemination and Implementation, Institute for Public Health Washington University in St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Golden","sequence":"additional","affiliation":[{"name":"Center for AIDS and STD University of Washington  Seattle Washington USA"},{"name":"Department of Epidemiology University of Washington  Seattle Washington USA"},{"name":"Division of Allergy and Infectious Diseases Department of Medicine, University of Washington  Seattle Washington USA"},{"name":"Public Health\u2010Seattle &amp; King County HIV\/STI\/HCV Program  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon D. L.","family":"Marshall","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti H.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa R.","family":"Metsch","sequence":"additional","affiliation":[{"name":"Department of Sociomedical Sciences Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce R.","family":"Schackman","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffanie A.","family":"Strathdee","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health, Department of Medicine University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hansel E.","family":"Tookes","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2513-3718","authenticated-orcid":false,"given":"Bohdan","family":"Nosyk","sequence":"additional","affiliation":[{"name":"Centre for Advancing Health Outcomes  Vancouver British Columbia Canada"},{"name":"Faculty of Health Sciences Simon Fraser University  Burnaby British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Localized Economic Modeling group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"HIV.gov. 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