{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T08:02:05Z","timestamp":1784880125862,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Multi\u2010month dispensing (MMD), as a differentiated service delivery model, can reduce the frequency of clinic visits, waiting time and travel costs for clinically stable people living with HIV. This study aimed to evaluate the impact of 6\u2010month MMD of antiretroviral therapy (ART) on retention and conduct a cost analysis in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a randomized, non\u2010blind, non\u2010inferiority study from December 2022 to March 2023 at The First Hospital of China Medical University. Eligible participants were randomly assigned to a 3\u2010month dispensing group (\n                      <jats:italic>n<\/jats:italic>\n                      = 789) or a 6\u2010month dispensing group (\n                      <jats:italic>n<\/jats:italic>\n                      = 799) and followed up for 18 months. The proportion of patients continuing ART after 18 months, virological suppression rate (&lt;50 copies\/mL) and average treatment cost per patient were evaluated. Cox regression analysis was used to compare treatment retention rates and virological suppression rates between groups, while descriptive statistical analysis was applied to assess cost differences. Cost metrics comprised the average cost per clinic visit and the price of ART medications, among other factors. This trial is registered with ChiCTR2200066438.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1588 participants were included (median age 40.0 years, IQR 34.0\u201350.0; 94.8% male), with no significant between\u2010group differences in demographic and clinical characteristics (all\n                      <jats:italic>p<\/jats:italic>\n                      &gt;0.05). In the intention\u2010to\u2010treat analysis, treatment retention rates at 18 months were 94.9% (749\/789) in the 3\u2010month dispensing group and 94.2% (753\/799) in the 6\u2010month dispensing group. The risk difference (6\u2010month minus 3\u2010month) was \u22120.7% (95% CI \u22122.9% to 1.5%); non\u2010inferiority was demonstrated as the lower bound of the 95% CI (\u22122.9%) exceeded the pre\u2010specified margin of \u22125%. Viral suppression rates (&lt;50 copies\/mL) were similarly high in both groups in intent\u2010to\u2010treat analysis: 94.9% (3\u2010month) versus 94.2% (6\u2010month), with no statistically significant difference. Per\u2010protocol analysis confirmed these findings (viral suppression 97.59%\u00a0vs. 97.75%; \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      = 0.0421,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.8375). In terms of cost, the 6\u2010month dispensing group had two fewer annual outpatient visits (3\u00a0vs. 5), with total treatment costs reduced by 27.7% (\u00a5931.82\u00a0vs. \u00a51288.85) and work value loss decreased by 16.7% (\u00a5174.20\u00a0vs. \u00a5209.04 yearly).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Six\u2010month MMD of ART did not reduce treatment retention; instead, it decreased patients\u2019 clinic visit costs, thereby meeting cost\u2010effectiveness criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Number<\/jats:title>\n                    <jats:p>ChiCTR2200066438.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jia2.70151","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:03:12Z","timestamp":1782291792000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["HIV Care Retention and Cost Analysis in Multi\u2010Month ART Dispensing: A Randomized Controlled Trial in China"],"prefix":"10.1002","volume":"29","author":[{"given":"Wenqi","family":"Shang","sequence":"first","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases NHC Key Laboratory of AIDS Prevention and Treatment National Clinical Research Center for Laboratory Medicine The First Hospital of China Medical University, China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases 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