{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:49:58Z","timestamp":1791881398199,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Persistent cervical infection with high\u2010risk human papillomavirus (HPV) in women is a leading cause of cervical cancer, and its co\u2010infection among people living with HIV increases the risk of other HPV\u2010associated cancers, including oropharyngeal and anogenital cancers. In sub\u2010Saharan Africa, awareness of HPV is limited, screening and vaccine adoption are critically low, undermining efforts towards sexually transmitted infection (STI) elimination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      <jats:bold>F<\/jats:bold>\n                      rom\n                      <jats:bold>A<\/jats:bold>\n                      wareness to A\n                      <jats:bold>CT<\/jats:bold>\n                      ion (FACT) study assessed HPV knowledge, screening and vaccine uptake among adolescent\u2212mother pairs participating in the HOMINY (\n                      <jats:bold>H<\/jats:bold>\n                      PV, Human Immunodeficiency Virus, and\n                      <jats:bold>O<\/jats:bold>\n                      ral\n                      <jats:bold>M<\/jats:bold>\n                      icrobiota\n                      <jats:bold>I<\/jats:bold>\n                      nterplay in\n                      <jats:bold>N<\/jats:bold>\n                      igerian\n                      <jats:bold>Y<\/jats:bold>\n                      ouths) prospective cohort study. Participants were enrolled, including adolescents aged 9\u201318 years (\n                      <jats:italic>N<\/jats:italic>\n                      = 636) and mothers aged 29\u201359 years (\n                      <jats:italic>N<\/jats:italic>\n                      = 385). FACT was conducted at the University of Benin Teaching Hospital, Nigeria, between April 2024 and July 2025, with adolescents and mothers grouped by HIV serostatus. In line with the national immunization programme protecting girls in Nigeria, sensitization programmes were integrated into the research study to promote awareness and adoption of screening and vaccination practices. Knowledge and attitudes regarding HPV and its vaccination benefits were assessed through thematic discussions, interactive sessions and questionnaires administered over the study period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HPV awareness was initially low, particularly among adolescents, but increased following sensitization, rising from 34.5% to 64.4% among mothers and from 1.4% to 19.0% among adolescents. Vaccination uptake rose from 0% to 5.4% (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0001) in adolescents aged 9\u201314 years. Among adolescents with perinatally acquired HIV, uptake increased from 1.9% to 4% over time (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003), and the proportion of mothers who underwent HPV\u2010related screening increased from 38.7% pre\u2010sensitization to 52.4% 12\u2010month post\u2010sensitization (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0001). Barriers to the adoption of preventive services included misconceptions, healthcare provider gaps, myths, misinformation, mistrust, scepticism and limited access.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HPV awareness programmes significantly improved knowledge, vaccination uptake and screening practices in this vulnerable population. As part of comprehensive STI elimination strategies, integrating HPV education and vaccination initiatives into HIV care and research will enhance prevention and address significant barriers. Lessons from a unique programmatic science framework provide critical insights for scaling vaccine delivery, and the design of future vaccine programmes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jia2.70164","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:21:22Z","timestamp":1784956882000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["From Awareness to Action Study: Improving Human Papillomavirus Knowledge, Screening and Vaccine Uptake Among Mother\u2010Adolescent Pairs in the HOMINY Study in Nigeria: A Longitudinal Study"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6713-0997","authenticated-orcid":false,"given":"Oluwaseun","family":"Peter","sequence":"first","affiliation":[{"name":"Institute of Human Virology Nigeria International Research Centre of Excellence  Federal Capital Territory Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elohor","family":"Oborevwori","sequence":"additional","affiliation":[{"name":"Johns Hopkins School of Nursing Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esosa","family":"Osagie","sequence":"additional","affiliation":[{"name":"Institute of Human Virology Nigeria International Research Centre of Excellence  Federal Capital Territory Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Akhigbe","sequence":"additional","affiliation":[{"name":"Institute of Human Virology Nigeria International Research Centre of Excellence  Federal Capital Territory Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nosakhare L.","family":"Idemudia","sequence":"additional","affiliation":[{"name":"Medical Laboratory Services Department of Medical Microbiology University of Benin Teaching Hospital  Benin Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozoemene","family":"Obuekwe","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University of Benin  Benin Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fidelis E.","family":"Eki\u2010Udoko","sequence":"additional","affiliation":[{"name":"Department of Child Health University of Benin Teaching Hospital  Benin Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2482-244X","authenticated-orcid":false,"given":"Nicolas","family":"Schlecht","sequence":"additional","affiliation":[{"name":"Roswell Park Comprehensive Cancer Center Cancer Prevention and Control  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yana","family":"Bromberg","sequence":"additional","affiliation":[{"name":"Department of Biology Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praise O.","family":"Okoh\u2010Aihe","sequence":"additional","affiliation":[{"name":"Department of Basic and Translational Sciences School of Dental Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1390-9753","authenticated-orcid":false,"given":"Nosayaba","family":"Osazuwa\u2010Peters","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery &amp; Communication Sciences Duke University School of Medicine  Durham North Carolina USA"},{"name":"Department of Population Health Sciences Duke University School of Medicine  Durham North Carolina USA"},{"name":"Duke Cancer Institute  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Modupe O.","family":"Coker","sequence":"additional","affiliation":[{"name":"Institute of Human Virology Nigeria International Research Centre of Excellence  Federal Capital Territory Nigeria"},{"name":"Department of Basic and Translational Sciences School of Dental Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of Oral Biology School of Dental Medicine Rutgers University  Newark New Jersey USA"},{"name":"Department of Epidemiology Geisel School of Medicine at Dartmouth  Hanover New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"HOMINY Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Human Papillomavirus (HPV) Vaccine Coverage Monitoring Manual","author":"WHO","year":"2020"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.9.709"},{"key":"e_1_2_11_5_1","first-page":"1","article-title":"Human Papillomaviruses","volume":"90","author":"IARC","year":"2007","journal-title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans"},{"key":"e_1_2_11_6_1","volume-title":"Statistics at a Glance","author":"Ferlay J.","year":"2022"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.70274"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001113"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8586459"},{"key":"e_1_2_11_10_1","first-page":"154","article-title":"Human Papilloma Virus Vaccine: Determinants of Acceptability by Mothers for Adolescents in Nigeria","volume":"18","author":"Ezeanochie M. 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