{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T06:28:46Z","timestamp":1786343326156,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"S3","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Although HIV pre\u2010exposure prophylaxis (PrEP) has been rapidly scaled up in Argentina to reach key populations with high HIV burden, evidence on real\u2010world persistence is lacking. Understanding who remains engaged in care, and why others discontinue, is essential to ensure the effectiveness of PrEP. This study evaluated oral PrEP persistence and identified demographic and behavioural factors associated with discontinuation in a cohort of individuals initiating PrEP in Buenos Aires.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective cohort study including all users initiating daily or event\u2010driven oral PrEP at our centre between September 2021 and July 2025. The cohort consisted of transgender women (TGW), men who have sex with men (MSM) and cisgender women engaged in sex work (cSW), in line with national PrEP guidelines. Persistence on PrEP was defined as the time to first discontinuation (TFD), either self\u2010reported or estimated as the date when the last dispensed PrEP pill would have been exhausted if taken daily. Categories for discontinuation included participant\u2010reported causes and loss to follow\u2010up (LTFU). TFD was evaluated using survival analysis. Cox proportional hazards models were fitted to examine associations between TFD and sociodemographic and behavioural factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 970 individuals initiated PrEP: 69% MSM, 24% TGW and 6% cSW. Median age was 31 years (IQR 26\u201336). During follow\u2010up, 447 participants (46%) discontinued PrEP. Persistence declined steadily over time: 91% at 1 month, 81% at 6 months, 72% at 12 months, 58% at 24 months and 43% at 36 months. Main categories for discontinuation were LTFU (44%), user decision or perceived low risk (46% combined) and adverse events (10%). In the multivariable model, younger age, identifying as TGW or cSW, cocaine use in the last month before baseline and the absence of basal\/follow\u2010up syphilis or other bacterial sexually transmitted infections were associated with PrEP discontinuation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Nearly half of the cohort discontinued PrEP over 3 years, with differences across key populations. These findings highlight the need for differentiated community\u2010tailored PrEP delivery models that address structural and behavioural barriers to improve long\u2010term PrEP engagement among key populations in Argentina and wider Latin America.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jia2.70175","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T06:38:36Z","timestamp":1785047916000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Persistence on Oral HIV Pre\u2010Exposure Prophylaxis Among Key Populations at a Centre in Buenos Aires: A Survival Analysis of a Real\u2010World Cohort"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4674-7903","authenticated-orcid":false,"given":"Julian L.","family":"Garcia","sequence":"first","affiliation":[{"name":"Research Department Fundaci\u00f3n Hu\u00e9sped  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6735-7173","authenticated-orcid":false,"given":"Diego","family":"Salusso","sequence":"additional","affiliation":[{"name":"Research Department Fundaci\u00f3n Hu\u00e9sped  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1224-3221","authenticated-orcid":false,"given":"Gissella","family":"Mernies","sequence":"additional","affiliation":[{"name":"Research Department Fundaci\u00f3n Hu\u00e9sped  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7357-342X","authenticated-orcid":false,"given":"Mar\u00eda M.","family":"Sandoval","sequence":"additional","affiliation":[{"name":"Research Department Fundaci\u00f3n Hu\u00e9sped  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Petriglieri","sequence":"additional","affiliation":[{"name":"Research Department Fundaci\u00f3n Hu\u00e9sped  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3911-4252","authenticated-orcid":false,"given":"Felipe","family":"Bilbao","sequence":"additional","affiliation":[{"name":"Research Department Fundaci\u00f3n Hu\u00e9sped  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9739-351X","authenticated-orcid":false,"given":"Daniela","family":"Parera","sequence":"additional","affiliation":[{"name":"Research Department Fundaci\u00f3n Hu\u00e9sped  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9507-0728","authenticated-orcid":false,"given":"Carolina","family":"Perez","sequence":"additional","affiliation":[{"name":"Research Department Fundaci\u00f3n Hu\u00e9sped  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6391-685X","authenticated-orcid":false,"given":"Adriana","family":"Duran","sequence":"additional","affiliation":[{"name":"Coordination of Sexual Health HIV and Sexually Transmitted Infections Ministry of Health  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1196-5620","authenticated-orcid":false,"given":"Ines","family":"Aristegui","sequence":"additional","affiliation":[{"name":"Research Department Fundaci\u00f3n Hu\u00e9sped  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0091-5150","authenticated-orcid":false,"given":"Maria Ines","family":"Figueroa","sequence":"additional","affiliation":[{"name":"Research Department Fundaci\u00f3n Hu\u00e9sped  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0495-3787","authenticated-orcid":false,"given":"Carina","family":"Cesar","sequence":"additional","affiliation":[{"name":"Research Department Fundaci\u00f3n Hu\u00e9sped  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,25]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Draft Recommendations\u2014Global Task Team for Setting 2030 HIV Targets [Internet]","author":"UNAIDS","year":"2025"},{"key":"e_1_2_12_3_1","volume-title":"Bolet\u00edn N\u00b0 42. 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