{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:10:59Z","timestamp":1790327459251,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23AI129854"],"award-info":[{"award-number":["K23AI129854"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI162235"],"award-info":[{"award-number":["R01AI162235"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD081929"],"award-info":[{"award-number":["R01HD081929"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23DK136388"],"award-info":[{"award-number":["K23DK136388"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24AI120834"],"award-info":[{"award-number":["K24AI120834"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>In non\u2010pregnant adults living with HIV, dolutegravir is associated with weight gain and increased type 2 diabetes risk. In pregnancy, data on the effect of dolutegravir on gestational diabetes (GDM) risk is inconclusive. Data are particularly limited in Asian populations, where diabetes risk is especially high and not always associated with weight gain. We examined the association of dolutegravir with GDM among women living with HIV in India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We combined data from two cohorts of pregnant women living with HIV conducted at BJ Government Medical College in Pune, India\u2014the PRACHITi study (2016\u22122019) and the PRAGATHi study (2023\u2212present). Women were screened for GDM with the fasting 2\u2010h 75\u00a0g oral glucose tolerance test and diagnosed by World Health Organization criteria. Demographics, anthropometrics, antiretroviral therapy (ART), CD4 count and HIV viral load were collected at screening. Multivariate logistic regression was used to determine the association between current dolutegravir use and GDM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 254 women living with HIV, 99.2% (\n                      <jats:italic>n<\/jats:italic>\n                      = 252) were on ART, of whom 66.3% (\n                      <jats:italic>n<\/jats:italic>\n                      = 167) were on dolutegravir\u2010, 22.6% (\n                      <jats:italic>n<\/jats:italic>\n                      = 57) were on efavirenz\u2010 and 6.3% (\n                      <jats:italic>n<\/jats:italic>\n                      = 16) were on protease inhibitor (PI)\u2010based ART. Overall, median CD4 count was 549.5 cells\/mm\n                      <jats:sup>3<\/jats:sup>\n                      (IQR 401\u2212753), and 82.2% (\n                      <jats:italic>n<\/jats:italic>\n                      = 198) had undetectable viral load. Median body\u2010mass index (BMI) was 21.3\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (IQR 19.4\u221223.8). The prevalence of GDM was 11.8% (\n                      <jats:italic>N<\/jats:italic>\n                      = 30). Among women on dolutegravir\u2010based ART, the prevalence was 10.8% (\n                      <jats:italic>N<\/jats:italic>\n                      = 18); among women on efavirenz\u2010based ART, the prevalence was 12.3% (\n                      <jats:italic>N<\/jats:italic>\n                      = 7), and the prevalence was 25% (\n                      <jats:italic>N<\/jats:italic>\n                      = 4) among women on PI\u2010based ART. Compared to women not taking dolutegravir, women taking dolutegravir had similar age and BMI but greater weight gain from the second to the third trimester (3.7\u00a0vs. 2.9\u00a0kg,\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.01) and infant birthweight percentile (14.2\u00a0vs. 6.9,\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.01). On multivariate logistic regression, dolutegravir use was associated with lower odds of GDM than other ART (aOR 0.2, 95% CI 0.1\u22121.0) irrespective of viral load and time on ART. Older age (aOR 1.1, 95% CI 1.1\u22121.2) and second\u2010trimester BMI (aOR 1.2 per kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , 95% CI 1.1\u22121.3) were also associated with GDM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Women on dolutegravir had lower odds of GDM compared to women taking other ART, despite greater weight gain. Ongoing studies are investigating the possible anti\u2010inflammatory mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jia2.70200","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:44:27Z","timestamp":1789969467000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dolutegravir Is Associated With Lower Odds of Gestational Diabetes Compared to Other Antiretroviral Therapy Regimens Among Pregnant Women in India: A Cross\u2010Sectional Analysis"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5422-2966","authenticated-orcid":false,"given":"Puja","family":"Chebrolu","sequence":"first","affiliation":[{"name":"Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0359-2649","authenticated-orcid":false,"given":"Farheen","family":"Ahmed","sequence":"additional","affiliation":[{"name":"University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3940-5439","authenticated-orcid":false,"given":"Sanjaykumar","family":"Tambe","sequence":"additional","affiliation":[{"name":"Byramjee Jeejeebhoy Medical College  Pune India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9332-7915","authenticated-orcid":false,"given":"Mallika","family":"Alexander","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Raichur","sequence":"additional","affiliation":[{"name":"Byramjee Jeejeebhoy Government Medical College\u2010Johns Hopkins University Clinical Research Site and Center for Infectious Diseases in India (CIDI)  Pune India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Kole","sequence":"additional","affiliation":[{"name":"Byramjee Jeejeebhoy Medical College Clinical Trials Unit  Pune India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonali","family":"Kante","sequence":"additional","affiliation":[{"name":"Byramjee Jeejeebhoy Government Medical College\u2010Johns Hopkins University Clinical Research Site and Center for Infectious Diseases in India (CIDI)  Pune India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vandana","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Byramjee Jeejeebhoy Government Medical College\u2010Johns Hopkins University Clinical Research Site and Center for Infectious Diseases in India (CIDI)  Pune India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Gupte","sequence":"additional","affiliation":[{"name":"Byramjee Jeejeebhoy Government Medical College\u2010Johns Hopkins University Clinical Research Site and Center for Infectious Diseases in India (CIDI)  Pune India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Bhosale","sequence":"additional","affiliation":[{"name":"Byramjee Jeejeebhoy Medical College  Pune India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9296-0353","authenticated-orcid":false,"given":"Shilpa","family":"Naik","sequence":"additional","affiliation":[{"name":"Byramjee Jeejeebhoy Medical College  Pune India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7036-2718","authenticated-orcid":false,"given":"Amita","family":"Gupta","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8599-278X","authenticated-orcid":false,"given":"Todd T.","family":"Brown","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9487-7775","authenticated-orcid":false,"given":"Jyoti S.","family":"Mathad","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Consolidated Guidelines on HIV Prevention, Testing, Treatment, Service Delivery and Monitoring: Recommendations for a Public Health Approach","year":"2021"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofad101"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41043-024-00695-0"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11111841"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2012.96"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13120"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00314-7"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.09.011"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3192"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcdhc.2024.1415069"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2021.09.010"},{"key":"e_1_2_11_13_1","volume-title":"Diagnostic Criteria and Classification of Hyperglycaemia First Detected in Pregnancy","author":"WHO","year":"2013"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.21\u20101106"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2008.500"},{"key":"e_1_2_11_16_1","unstructured":"World Health Organization WHO STEPS Surveillance Manual(2017)."},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2015.04.006"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaf047"},{"key":"e_1_2_11_19_1","unstructured":"C.Lameck E.Goldberg andK.McCathy \u201cPregnancy Hemoglobin A1c and Glucose With DTG vs EFV TDF vs TAF: IMPAACT 2010 \u201d inConference on Retroviruses and Opportunistic Infections(2022) 687."},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz999"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1403"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.10.1179"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcd.2022.09.007"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12903"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab745"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcte.2020.100226"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/dbi24\u20100041"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/25787489.2022.2080625"},{"key":"e_1_2_11_29_1","first-page":"1","article-title":"Oxidative Stress\u2010Mediated Beta Cell Death and Dysfunction as a Target for Diabetes Management","author":"Dini\u0107 S.","year":"2022","journal-title":"Frontiers in Endocrinology"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175288"}],"container-title":["Journal of the International AIDS Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jia2.70200","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jia2.70200","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jia2.70200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:41:12Z","timestamp":1790325672000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jia2.70200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/jia2.70200"],"URL":"https:\/\/doi.org\/10.1002\/jia2.70200","archive":["Portico"],"relation":{},"ISSN":["1758-2652","1758-2652"],"issn-type":[{"value":"1758-2652","type":"print"},{"value":"1758-2652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2025-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70200"}}