{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:21:46Z","timestamp":1791822106720,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"S5","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R34 MH128002\/MH\/NIMH"],"award-info":[{"award-number":["R34 MH128002\/MH\/NIMH"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH HHS\/United States"],"award-info":[{"award-number":["NIH HHS\/United States"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>To address suboptimal HIV pre\u2010exposure prophylaxis (PrEP) uptake among Black women, we designed PrEP4Her, a multi\u2010phase, multi\u2010component implementation strategy aimed to increase PrEP prescriptions among women receiving routine health services at a university\u2010affiliated gynaecology (GYN) clinic located in the Southeastern United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Informed by intervention mapping, PrEP4Her, a hybrid type 3 trial, was piloted over 8 months, January 2024\u2013August 2024, and the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE\u2010AIM) conceptual framework guided the evaluation of proximal implementation outcomes. In this manuscript, we present (1)\n                      <jats:italic>Reach<\/jats:italic>\n                      (the number of Black women prescribed PrEP and the proportion of PrEP prescribed to women with an indication, having a sexually transmitted infection (STI) within 12 months and\/or reporting &gt;1 sex partners collected from a universal health screener); (2)\n                      <jats:italic>Adoption<\/jats:italic>\n                      (the number of PrEP prescribers); (3)\n                      <jats:italic>Preliminary Effectiveness<\/jats:italic>\n                      (PrEP prescribed over time). Also, we measured the number of Black women who self\u2010reported talking to a doctor about PrEP as a secondary outcome\n                      <jats:italic>(Fidelity)<\/jats:italic>\n                      . We collected evaluative data from the electronic health record (EHR), sexual health screener and self\u2010administered post\u2010visit survey. Descriptive statistics were utilized to describe the sample, and chi\u2010square tests examined the relationships between patient characteristics and talking to providers about PrEP. Analyses were completed in October 2025.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      EHR data indicate there were 1274 unique first clinic visits. Most women identified as Black race (58%) and, on average, were 34 (\u00b111.3) years old. Ten PrEP prescriptions were written by seven prescribers (i.e. adoption). Among women prescribed PrEP, nine identified as Black women and none had a recent STI (i.e. reach). PrEP was prescribed once before the pilot, eight times during the pilot and once in the month after the pilot. However, PrEP was not prescribed to women with PrEP indications (\n                      <jats:italic>N<\/jats:italic>\n                      = 85) (i.e. preliminary effectiveness). Nearly half (43%) of surveyed women reported talking to a provider about PrEP (i.e. fidelity); most (49%) identified as Black race. Chi\u2010square tests show significant differences by race (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We observed an increase in PrEP prescriptions from before to during the pilot period; however, 85 women with PrEP indications were not prescribed PrEP. Future research will further evaluate PrEP4Her's acceptability and feasibility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jia2.70208","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:49:02Z","timestamp":1791528542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["PrEP4Her: Evaluating the Reach, Adoption, Preliminary Effectiveness and Fidelity of a Multi\u2010Component Hybrid Type 3 Trial Designed to Increase PrEP Prescriptions for Black Women Receiving Gynaecologic Care in a University\u2010Affiliated Women's Health Setting in the United States South"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0006-8091","authenticated-orcid":false,"given":"Anais","family":"Mahone","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Heersink School of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8026-472X","authenticated-orcid":false,"given":"Audra","family":"Williams","sequence":"additional","affiliation":[{"name":"Division of Women's Reproductive Healthcare Department of Obstetrics and Gynecology Heersink School of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dave","family":"Cleveland","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham (UAB) Center for AIDS Research, University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Heersink School of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Watson","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Heersink School of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam\u2010Colette","family":"Kempf","sequence":"additional","affiliation":[{"name":"Schools of Nursing Public Health and Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6167-6328","authenticated-orcid":false,"given":"Lynn T.","family":"Matthews","sequence":"additional","affiliation":[{"name":"School of Medicine Yale University  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6916-6701","authenticated-orcid":false,"given":"Michael J.","family":"Mugavero","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Heersink School of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latesha E.","family":"Elopre","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Heersink School of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"CDC Fast Facts: HIV and Women.HIV https:\/\/www.cdc.gov\/hiv\/data\u2010research\/facts\u2010stats\/women.html(2025 accessed 30 October 2025)."},{"key":"e_1_2_11_3_1","unstructured":"Conversation Starters Start Talking. 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C.","year":"2025","journal-title":"Womens Health"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-023-04188-9"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.12.263"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/frhs.2025.1567688"},{"key":"e_1_2_11_19_1","first-page":"A200","article-title":"P420 Understanding PrEP Service Delivery Preferences Among Black Women in Urban and Rural Counties in the US Deep South","volume":"95","author":"Elopre L.","year":"2019","journal-title":"Sexually Transmitted Infections"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.2196\/58976"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofae631.704"},{"key":"e_1_2_11_22_1","unstructured":"Clinical Guidance for PrEP https:\/\/www.cdc.gov\/hivnexus\/hcp\/prep\/index.html(30 April 2026)."},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2023.07.046"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/frph.2023.1196392"},{"key":"e_1_2_11_25_1","first-page":"348","article-title":"Training Obstetrician Gynaecologists in HIV PrEP (Pre\u2010Exposure Prophylaxis): A 2\u2010Year Experience","volume":"99","author":"Silvestri F.","year":"2023","journal-title":"Sexually Transmitted Infections"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2025.0022"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(19)30137-7"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2020.10.005"}],"container-title":["Journal of the International AIDS Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jia2.70208","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jia2.70208","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jia2.70208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T05:12:21Z","timestamp":1791781941000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jia2.70208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":27,"journal-issue":{"issue":"S5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/jia2.70208"],"URL":"https:\/\/doi.org\/10.1002\/jia2.70208","archive":["Portico"],"relation":{},"ISSN":["1758-2652","1758-2652"],"issn-type":[{"value":"1758-2652","type":"print"},{"value":"1758-2652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2025-11-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70208"}}