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In this study, tissue distribution was investigated in normal cats that received a single 120\u2010mg dose of [<jats:sup>14<\/jats:sup>C]\u2010HP\u2010\u03b2\u2010CD (approximately 200\u2009\u03bcCi\/cat) via the cerebellomedullary cistern (CBMC) and lumbar cistern. One cat was euthanized at each of various time points up to 24\u2009hours postdose for subsequent processing and quantitative whole\u2010body autoradiographic analysis. HP\u2010\u03b2\u2010CD\u2010derived radioactivity absorbed from the CBMC was widely distributed to cat tissues; most tissues were observed to have reached their highest concentration at 1\u2009hour postdose. HP\u2010\u03b2\u2010CD\u2010derived radioactivity penetrated into the deeper parts of the central nervous system with the highest concentration at 4 hours (403\u2009\u03bcg\u2009Eq\/g or 0.28\u2009mM) and remained high (49.7 \u03bcg\u2009Eq\/g or 0.03\u2009mM) at 24\u2009hours. The relatively long half\u2010life (11\u201030\u2009hours) in cerebral ventricles and the subarachnoid space surrounding the brain and spinal cord might contribute to the efficacy of HP\u2010\u03b2\u2010CD in NPC1 cats. Other tissues with high concentrations of radioactivity were nasal turbinates, pituitary gland, and urinary bladder, while relatively low concentrations were observed in blood and bile.<\/jats:p>","DOI":"10.1002\/jimd.12189","type":"journal-article","created":{"date-parts":[[2019,11,10]],"date-time":"2019-11-10T07:20:22Z","timestamp":1573370422000},"page":"618-634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pharmacokinetics and distribution of 2\u2010hydroxypropyl\u2010\u03b2\u2010cyclodextrin following a single intrathecal dose to cats"],"prefix":"10.1002","volume":"43","author":[{"given":"Mark L.","family":"Kao","sequence":"first","affiliation":[{"name":"Janssen Research &amp; Development LLC  Raritan New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Stellar","sequence":"additional","affiliation":[{"name":"Janssen Research &amp; Development LLC  Raritan New 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