{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T14:07:53Z","timestamp":1771942073427,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,15]],"date-time":"2019-12-15T00:00:00Z","timestamp":1576368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The prevalence of arterial hypertension in mitochondrial diseases remains unknown. Between January 2000 and May 2014, we retrospectively included patients with genetically proven mitochondrial diseases. We recorded clinical, genetic and cardiac exploration data, including the measure of arterial pressure. Among the 260 patients included in the study (mean age = 44 \u00b1\u200915\u2009years, women = 158), 108 (41.5%) presented with arterial hypertension. The prevalence of hypertension by sex and age was higher than that observed in the general population for all groups. The prevalence of hypertension was significantly higher in patients with MELAS (mitochondrial encephalopathy, lactic acidosis, and stroke\u2010like episodes) mutations (66%) and MERRF (myoclonus, epilepsy, ataxia with ragged ref fibres) mutations (61%). In patients with MELAS mutation, the presence of hypertension was significantly associated with age and mutation rate in the blood (odds ratio = 1.12; <jats:italic>P<\/jats:italic> = .02) in multivariate analysis. The prevalence of hypertension was more important in patients having a mitochondrial disease. The increased risk was more important in patient with MELAS or MERRF and depended on the rate of heteroplasmy.<\/jats:p>","DOI":"10.1002\/jimd.12195","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T02:14:03Z","timestamp":1574648043000},"page":"478-485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A high prevalence of arterial hypertension in patients with mitochondrial diseases"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2575-7929","authenticated-orcid":false,"given":"Caroline","family":"Chong\u2010Nguyen","sequence":"first","affiliation":[{"name":"Cardiology Department, AP\u2010HP, Cochin Hospital FILNEMUS, Centre de R\u00e9f\u00e9rence de Pathologie Neuromusculaire Nord\/Est\/Ile de France  Paris France"},{"name":"Universit\u00e9 Paris Descartes\u2010Sorbonne Paris Cit\u00e9  Paris France"},{"name":"AP\u2010HP, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, Reference Center for Muscle Diseases Paris\u2010Est Myology Institute  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Stalens","sequence":"additional","affiliation":[{"name":"Paris Cardiovascular Research Centre (Inserm U970)  Paris France"},{"name":"Medical Affairs Department AFM\u2010Telethon  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Goursot","sequence":"additional","affiliation":[{"name":"Cardiology Department, AP\u2010HP, Cochin Hospital FILNEMUS, Centre de R\u00e9f\u00e9rence de Pathologie Neuromusculaire Nord\/Est\/Ile de France  Paris France"},{"name":"Universit\u00e9 Paris Descartes\u2010Sorbonne Paris Cit\u00e9  Paris France"},{"name":"AP\u2010HP, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, Reference Center for Muscle Diseases Paris\u2010Est Myology Institute  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wulfran","family":"Bougouin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes\u2010Sorbonne Paris Cit\u00e9  Paris France"},{"name":"Medical Intensive Care Unit AP\u2010HP, Cochin Hospital  Paris France"},{"name":"Paris Cardiovascular Research Centre (PARCC), INSERM Unit 970  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya","family":"Stojkovic","sequence":"additional","affiliation":[{"name":"AP\u2010HP, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, Reference Center for Muscle Diseases Paris\u2010Est Myology Institute  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"B\u00e9hin","sequence":"additional","affiliation":[{"name":"AP\u2010HP, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, Reference Center for Muscle Diseases Paris\u2010Est Myology Institute  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanny","family":"Mochel","sequence":"additional","affiliation":[{"name":"Pierre et Marie Curie\u2010Paris 6 University, Myology Institute, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"},{"name":"Genetics Department INSERM UMR S975, CNRS UMR7225, ICM, AP\u2010HP, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nawal","family":"Berber","sequence":"additional","affiliation":[{"name":"AP\u2010HP, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, Reference Center for Muscle Diseases Paris\u2010Est Myology Institute  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Eymard","sequence":"additional","affiliation":[{"name":"AP\u2010HP, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, Reference Center for Muscle Diseases Paris\u2010Est Myology Institute  Paris France"},{"name":"Pierre et Marie Curie\u2010Paris 6 University, Myology Institute, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Duboc","sequence":"additional","affiliation":[{"name":"Cardiology Department, AP\u2010HP, Cochin Hospital FILNEMUS, Centre de R\u00e9f\u00e9rence de Pathologie Neuromusculaire Nord\/Est\/Ile de France  Paris France"},{"name":"Universit\u00e9 Paris Descartes\u2010Sorbonne Paris Cit\u00e9  Paris France"},{"name":"INSERM Unit 970, Paris Cardiovascular Research Centre (PARCC)  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Lafor\u00eat","sequence":"additional","affiliation":[{"name":"AP\u2010HP, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, Reference Center for Muscle Diseases Paris\u2010Est Myology Institute  Paris France"},{"name":"Pierre et Marie Curie\u2010Paris 6 University, Myology Institute, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karim","family":"Wahbi","sequence":"additional","affiliation":[{"name":"Cardiology Department, AP\u2010HP, Cochin Hospital FILNEMUS, Centre de R\u00e9f\u00e9rence de Pathologie Neuromusculaire Nord\/Est\/Ile de France  Paris France"},{"name":"Universit\u00e9 Paris Descartes\u2010Sorbonne Paris Cit\u00e9  Paris France"},{"name":"INSERM Unit 970, Paris Cardiovascular Research Centre (PARCC)  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.07.004"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra022567"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv307"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2009.09.005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/8904_2013_239"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328285a36e"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy339"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.12.013"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014"},{"key":"e_1_2_7_11_1","first-page":"170","article-title":"L'hypertension art\u00e9rielle en France: pr\u00e9valence, traitement et contr\u00f4le en 2015 et \u00e9volution depuis 2006","volume":"10","author":"Perrine AL","year":"2018","journal-title":"Behaviour"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2004.02.020"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.4238\/2015.December.21.42"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2008.151"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2016.08.008"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000220197.36849.1e"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.09.012"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000258450.44413.96"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.151"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2001.600103.x"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jimd.12195","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jimd.12195","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jimd.12195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T18:25:44Z","timestamp":1693679144000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jimd.12195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,15]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1002\/jimd.12195"],"URL":"https:\/\/doi.org\/10.1002\/jimd.12195","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,15]]},"assertion":[{"value":"2019-07-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}