{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:18:43Z","timestamp":1790065123808,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T00:00:00Z","timestamp":1591228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Many similarities between tryptophan (Trp) and phenylalanine (Phe) metabolisms exist. It is possible that a modification of Trp metabolism might be seen in phenylketonuria (PKU). As some of these metabolites have neuroactive properties, they should be consider in neurological impairment seen in this pathology and not totally explained by blood Phe concentrations. One hundred and fifty\u2010one adult PKU patients (mean age 26.8\u2009years) were included for this study. Plasma Trp, kynurenine (KYN), 3\u2010hydroxykynurenic acid (3HK), and kynurenic acid (KA) were analyzed by liquid chromatography coupled with tandem mass spectrometry. KYN and 3HK were significantly lower in PKU patients compared to general population (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001), and KA was significantly enhanced is this population (<jats:italic>P<\/jats:italic> = .009). Furthermore, 3HK concentration was significantly different between PKU patients underwent controlled low\u2010Phe diet compared to PKU patients without this diet (<jats:italic>P<\/jats:italic> = .0016). In PKU patients with diet, taking AA substitute enable higher plasma 3HK concentration than without (<jats:italic>P<\/jats:italic> = .0008) but still not reaching general population level (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001). Although further study has to be done, it is clear that Trp metabolism is modified in adult PKU patients. An exploration of complete Trp metabolism, and not only Trp concentration, is needed in PKU population, but also in other inborn error of metabolism treated with hypoprotidic diet.<\/jats:p>","DOI":"10.1002\/jimd.12250","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T19:02:33Z","timestamp":1589223753000},"page":"944-951","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Tryptophan metabolism in phenylketonuria: A French adult cohort study"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3036-7378","authenticated-orcid":false,"given":"Lysiane","family":"Boulet","sequence":"first","affiliation":[{"name":"Laboratoire des Maladies H\u00e9r\u00e9ditaires du M\u00e9tabolisme, Service de Biochimie, Biologie Mol\u00e9culaire Toxicologie Environnementale, CHU de Grenoble\u2010Alpes site Nord\u2010 Institut de Biologie et de Pathologie  La Tronche 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