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We studied plasma proteomic and lipidomic profiles in 12 PD patients compared to age\u2010matched controls. The proteomic profiles were analyzed by nLC\u2010MS\/MS SWATH method. Wide\u2010targeted lipidomic analysis was performed by LC\u2010IMS\/MS, allowing to quantify &gt;1100 lipid species, spanning 13 classes. Significant differences were found for 16 proteins, with four showing the most relevant changes (GPLD1, PON1, LDHB, PKM). Lipidomic analysis showed elevated levels of three phosphatidylcholines and of the free fatty acid 22:4, and reduced levels of six lysophosphatidylcholines. Up\u2010regulated glycolytic enzymes (LDHB and PKM) are involved in autophagy and glycogen metabolism, while down\u2010regulated PON1 and GPLD1 combined with lipidomic data indicate an abnormal phospholipid metabolism. Reduced GPLD1 and dysregulation of lipids with acyl\u2010chains characteristic of GPI\u2010anchor structure suggest the potential involvement of GPI\u2010anchor system in PD. Results of proteomic analysis displayed the involvement of multiple cellular functions affecting inflammatory, immune and antioxidant responses, autophagy, Ca<jats:sup>2+<\/jats:sup>\u2010homeostasis, and cell adhesion. 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