{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T18:30:03Z","timestamp":1783103403451,"version":"3.54.6"},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Continuous glucose monitoring (CGM) systems have great potential for real\u2010time assessment of glycemic variation in patients with hepatic glycogen storage disease (GSD). However, detailed descriptions and in\u2010depth analysis of CGM data from hepatic GSD patients during interventions are scarce. This is a retrospective in\u2010depth analysis of CGM parameters, acquired in a continuous, real\u2010time fashion describing glucose management in 15 individual GSD patients. CGM subsets are obtained both in\u2010hospital and at home, upon nocturnal dietary intervention (n\u00a0=\u00a01), starch loads (n\u00a0=\u00a011) and treatment of GSD Ib patients with empagliflozin (n\u00a0=\u00a03). Descriptive CGM parameters, and parameters reflecting glycemic variation and glycemic control are considered useful CGM outcome parameters. Furthermore, the combination of first and second order derivatives, cumulative sum and Fourier analysis identified both subtle and sudden changes in glucose management; hence, aiding assessment of dietary and medical interventions. CGM data interpolation for nocturnal intervals reduced confounding by physical activity and diet. Based on these analyses, we conclude that in\u2010depth CGM analysis can be a powerful tool to assess glucose management and optimize treatment in individual hepatic GSD patients.<\/jats:p>","DOI":"10.1002\/jimd.12383","type":"journal-article","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T06:40:29Z","timestamp":1617950429000},"page":"1136-1150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["A retrospective in\u2010depth analysis of continuous glucose monitoring datasets for patients with hepatic glycogen storage disease: Recommended outcome parameters for glucose management"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2961-9726","authenticated-orcid":false,"given":"Fabian","family":"Peeks","sequence":"first","affiliation":[{"name":"Section of Metabolic Diseases Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene J.","family":"Hoogeveen","sequence":"additional","affiliation":[{"name":"Section of Metabolic Diseases Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Lude","family":"Feldbrugge","sequence":"additional","affiliation":[{"name":"enerGQ BV  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Burghard","sequence":"additional","affiliation":[{"name":"enerGQ BV  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Foekje","family":"de Boer","sequence":"additional","affiliation":[{"name":"Section of Metabolic Diseases Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke J.","family":"Fokkert\u2010Wilts","sequence":"additional","affiliation":[{"name":"Section of Metabolic Diseases Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7178-009X","authenticated-orcid":false,"given":"Melanie M.","family":"van der Klauw","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4117-7833","authenticated-orcid":false,"given":"Maaike H.","family":"Oosterveer","sequence":"additional","affiliation":[{"name":"Laboratory of Pediatrics University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7259-1095","authenticated-orcid":false,"given":"Terry G. J.","family":"Derks","sequence":"additional","affiliation":[{"name":"Section of Metabolic Diseases Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2018.07.004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2017.11.005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12540"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.128"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181e655b6"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-018-0364-2"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02680007"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-016-9932-2"},{"issue":"1","key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"S120","DOI":"10.1007\/BF02680008","article-title":"Consensus guidelines for management of glycogen storage disease type 1b \u2010 European study on glycogen storage disease type 1","volume":"161","author":"Visser G","year":"2002","journal-title":"Eur J Pediatr"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-020-0878-2"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jimd.12178"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics3040385"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-2482"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/js.2017-00388"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-Sint"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1600"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-2534"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2017.0035"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-0133"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2016.10.007"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2019.02.008"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2013.186"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.518"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-011-9335-3"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-018-0200-5"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/1932296816685717"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/193229680700100506"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2018.0092"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1624"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.14286"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019004465"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2014.0415"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2018.0150"},{"key":"e_1_2_9_35_1","volume-title":"Dexcom G4 PLATINUM CGM System with Share","author":"Dexcom, Inc","year":"2019"},{"key":"e_1_2_9_36_1","volume-title":"Make Knowledge your Superpower with the Dexcom G6\u00ae CGM System","author":"Dexcom, Inc","year":"2019"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.26.11.1016"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-305718"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.171.6.9843315"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-019-01893-1"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4423-z"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2016.0146"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-019-0870-x"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2017.0455"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2017.09.003"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/8904_2013_283"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsn017"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2017.08.005"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.2196\/11030"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.2196\/18660"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2019.090"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2017.0363"},{"issue":"5","key":"e_1_2_9_53_1","first-page":"695","volume":"40","author":"Peeks F","year":"2017","journal-title":"Clinical and biochemical heterogeneity between patients with glycogen storage disease type Ia: the added value of CUSUM for metabolic control"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jimd.12383","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jimd.12383","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jimd.12383","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T03:25:03Z","timestamp":1693106703000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jimd.12383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,5]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/jimd.12383"],"URL":"https:\/\/doi.org\/10.1002\/jimd.12383","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,5]]},"assertion":[{"value":"2021-01-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}