{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:30:17Z","timestamp":1788888617724,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GA 354\/14\u20101"],"award-info":[{"award-number":["GA 354\/14\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010570","name":"Nieders\u00e4chsisches Ministerium f\u00fcr Wissenschaft und Kultur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010570","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>X\u2010linked adrenoleukodystrophy (X\u2010ALD) is the most common leukodystrophy. Despite intensive research in recent years, it remains unclear, what drives the different clinical disease courses. Due to this missing pathophysiological link, therapy for the childhood cerebral disease course of X\u2010ALD (CCALD) remains symptomatic; the allogenic hematopoietic stem cell transplantation or hematopoietic stem\u2010cell gene therapy is an option for early disease stages. The inclusion of dried blood spot (DBS) C26:0\u2010lysophosphatidylcholine to newborn screening in an increasing number of countries is leading to an increasing number of X\u2010ALD patients diagnosed at risk for CCALD. Current follow\u2010up in asymptomatic boys with X\u2010ALD requires repetitive cerebral MRIs under sedation. A reliable and easily accessible biomarker that predicts CCALD would therefore be of great value. Here we report the application of targeted metabolomics by AbsoluteIDQ p180\u2010Kit from Biocrates to search for suitable biomarkers in X\u2010ALD. LysoPC a C20:3 and lysoPC a C20:4 were identified as metabolites that indicate neuroinflammation after induction of experimental autoimmune encephalitis in the serum of <jats:italic>Abcd1<\/jats:italic><jats:sup><jats:italic>tm1Kds<\/jats:italic><\/jats:sup> mice. Analysis of serum from X\u2010ALD patients also revealed different concentrations of these lipids at different disease stages. Further studies in a larger cohort of X\u2010ALD patient sera are needed to prove the diagnostic value of these lipids for use as early biomarkers for neuroinflammation in CCALD patients.<\/jats:p>","DOI":"10.1002\/jimd.12389","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T20:34:03Z","timestamp":1618518843000},"page":"1174-1185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Targeted metabolomics revealed changes in phospholipids during the development of neuroinflammation in <scp><i>Abcd1<\/i><sup><i>tm1Kds<\/i><\/sup><\/scp> mice and X\u2010linked adrenoleukodystrophy patients"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4804-7716","authenticated-orcid":false,"given":"Matthias","family":"Kettwig","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Division of Pediatric Neurology, University Medical Center G\u00f6ttingen Georg August University  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Klemp","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Division of Pediatric Neurology, University Medical Center G\u00f6ttingen Georg August University  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Nessler","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology, University Medical Center G\u00f6ttingen Georg August University  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Streit","sequence":"additional","affiliation":[{"name":"Institute for Clinical Chemistry, University Medical Center G\u00f6ttingen Georg August University  G\u00f6ttingen 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