{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:56Z","timestamp":1786978076665,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T00:00:00Z","timestamp":1620864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009908","name":"Grosserer L. F. Foghts Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009908","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010809","name":"Jascha Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mitochondrial myopathies (MM) are caused by mutations that typically affect genes involved in oxidative phosphorylation. Main symptoms are exercise intolerance and fatigue. Currently, there is no specific treatment for MM. Resveratrol (RSV) is a nutritional supplement that in preclinical studies has been shown to stimulate mitochondrial function. We hypothesized that RSV could improve exercise capacity in patients with MM. The study design was randomized, double\u2010blind, cross\u2010over and placebo\u2010controlled. Eleven patients with genetically verified MM were randomized to receive either 1000\u2009mg\/day RSV or placebo (P) for 8\u2009weeks followed by a 4\u2010week washout and then the opposite treatment. Primary outcomes were changes in heart rate (HR) during submaximal cycling exercise and peak oxygen utilization (VO\n                    <jats:sub>2<\/jats:sub>\n                    max) during maximal exercise. Secondary outcomes included reduction in perceived exertion, changes in lactate concentrations, self\u2010rated function (SF\u201036) and fatigue scores (FSS), activities of electron transport chain complexes I and IV in mononuclear cells and mitochondrial biomarkers in muscle tissue among others. There were no significant differences in primary and secondary outcomes between treatments. Mean HR changes were \u22120.3\u2009\u00b1\u20094.3 (RSV) vs 1.8\u2009\u00b1\u20095.0\u2009bpm (P),\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.241. Mean VO\n                    <jats:sub>2<\/jats:sub>\n                    max changes were 0.7\u2009\u00b1\u20091.4 (RSV) vs \u22120.2\u2009\u00b1\u20092.3\u2009mL\/min\/kg (P),\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.203. The study provides evidence that 1000\u2009mg RSV daily is ineffective in improving exercise capacity in adults with MM. These findings indicate that previous\n                    <jats:italic>in vitro<\/jats:italic>\n                    studies suggesting a therapeutic potential for RSV in MM, do not translate into clinically meaningful effects\n                    <jats:italic>in vivo<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/jimd.12393","type":"journal-article","created":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T08:50:33Z","timestamp":1619945433000},"page":"1186-1198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["No effect of resveratrol in patients with mitochondrial myopathy: A cross\u2010over randomized controlled trial"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5494-8484","authenticated-orcid":false,"given":"Nicoline","family":"L\u00f8kken","sequence":"first","affiliation":[{"name":"Copenhagen Neuromuscular Center, Rigshospitalet 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