{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:52Z","timestamp":1786978072634,"version":"build-2736575974"},"reference-count":203,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002651","name":"Barth Syndrome Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002651","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005970","name":"Deutsche Stiftung f\u00fcr Herzforschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Energy\u2010demanding organs like the heart are strongly dependent on oxidative phosphorylation in mitochondria. Oxidative phosphorylation is governed by the respiratory chain located in the inner mitochondrial membrane. The inner mitochondrial membrane is the only cellular membrane with significant amounts of the phospholipid cardiolipin, and cardiolipin was found to directly interact with a number of essential protein complexes, including respiratory chain complexes I to V. An inherited defect in the biogenesis of cardiolipin causes Barth syndrome, which is associated with cardiomyopathy, skeletal myopathy, neutropenia and growth retardation. Energy conversion is dependent on reducing equivalents, which are replenished by oxidative metabolism in the Krebs cycle. Cardiolipin deficiency in Barth syndrome also affects Krebs cycle activity, metabolite transport and mitochondrial morphology. During excitation\u2010contraction coupling, calcium (Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ) released from the sarcoplasmic reticulum drives sarcomeric contraction. At the same time, Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influx into mitochondria drives the activation of Krebs cycle dehydrogenases and the regeneration of reducing equivalents. Reducing equivalents are essential not only for energy conversion, but also for maintaining a redox buffer, which is required to detoxify reactive oxygen species (ROS). Defects in CL may also affect Ca\n                    <jats:sup>2+<\/jats:sup>\n                    uptake into mitochondria and thereby hamper energy supply and demand matching, but also detoxification of ROS. Here, we review the impact of cardiolipin deficiency on mitochondrial function in Barth syndrome and discuss potential therapeutic strategies.\n                  <\/jats:p>","DOI":"10.1002\/jimd.12427","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T03:40:45Z","timestamp":1629690045000},"page":"82-98","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Mechano\u2010energetic aspects of Barth syndrome"],"prefix":"10.1002","volume":"45","author":[{"given":"Jan","family":"Dudek","sequence":"first","affiliation":[{"name":"Comprehensive Heart Failure Center (CHFC) University Clinic W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Maack","sequence":"additional","affiliation":[{"name":"Comprehensive Heart Failure Center (CHFC) University Clinic W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318241"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0044-6"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.5.3.393"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2014.06.007"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2013.07.011"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2013.07.002"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.07.003"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt209"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(99)00032-5"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(75)80217-4"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951107000042"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0496-385"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/301604"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-015-1260-z"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35609"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2667"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00479.2010"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-005-0873-z"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-019-1006-8"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jimd.12094"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(83)90209-5"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.11.003"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-11-3940"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-23"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2004.tb02974.x"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgmr.2020.100675"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151802"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2014.03.007"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-020-04021-0"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.753624"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201006159"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200812018"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.06.013"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M405932200"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2019.04.017"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04202.x"},{"key":"e_1_2_15_38_1","doi-asserted-by":"crossref","unstructured":"XiaoJ EngelJL ZhangJ ChenMJ ManningG DixonJE.Structural and functional analysis of PTPMT1 a phosphatase required for cardiolipin synthesis.2011;108:11860\u201011865.","DOI":"10.1073\/pnas.1109290108"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M305242200"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108676"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.24.14933"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20060303"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(91)90165-E"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.268482.115"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M402930200"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.069591"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811224106"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M707795200"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M606100200"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2009.01.032"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2007.095711"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA117.001024"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02532585"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M015966"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2013.10.005"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2113"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2760(97)00170-7"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M601770200"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.01.004"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8922"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1225625"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2009.10.074"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.02.115"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e32834fdaf7"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1064"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1900890116"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2019.04.020"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M034728"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.201900348"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(98)00221-4"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp181"},{"key":"e_1_2_15_72_1","first-page":"141","article-title":"Evidence of cardiocyte apoptosis in myocardium of dogs with chronic heart failure","volume":"148","author":"Sharov VG","year":"1996","journal-title":"Am J Pathol"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.008476"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa343"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-226225"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.08.045"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0248554"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2006.04.011"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.171439"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700480"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.03.005"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-014-1237-z"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1617288114"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad2459"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0210-7"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1487"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.531921"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2010.01.002"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2018.01.005"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad0116"},{"key":"e_1_2_15_91_1","first-page":"335","article-title":"Molecular basis of selective mitochondrial fusion by heterotypic action between OPA1 and cardiolipin","volume":"505","author":"Ban T","year":"2017","journal-title":"Nat Cell Biol"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200906098"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi801723d"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201311014"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11008-3"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.74"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.342105"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-018-6805-y"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep45076"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1586256"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.39598"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00268"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-015-9819-7"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2016.52"},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07534"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.266585"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.030235"},{"key":"e_1_2_15_108_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2018101056"},{"key":"e_1_2_15_109_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201949776"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2018.04.037"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.07739"},{"key":"e_1_2_15_112_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063683"},{"key":"e_1_2_15_113_1","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202000711"},{"key":"e_1_2_15_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.08.041"},{"key":"e_1_2_15_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2018.04.013"},{"key":"e_1_2_15_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.138"},{"key":"e_1_2_15_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature19794"},{"key":"e_1_2_15_118_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.23.6591"},{"key":"e_1_2_15_119_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M302195200"},{"key":"e_1_2_15_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601618"},{"key":"e_1_2_15_121_1","doi-asserted-by":"crossref","unstructured":"DuncanAL RobinsonAJ WalkerJE.Cardiolipin binds selectively but transiently to conserved lysine residues in the rotor of metazoan ATP synthases.2016;113:8687\u20108692.","DOI":"10.1073\/pnas.1608396113"},{"key":"e_1_2_15_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)45391-9"},{"key":"e_1_2_15_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.175"},{"key":"e_1_2_15_124_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E05-03-0256"},{"key":"e_1_2_15_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature19774"},{"key":"e_1_2_15_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.06.057"},{"key":"e_1_2_15_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.11.012"},{"key":"e_1_2_15_128_1","doi-asserted-by":"crossref","unstructured":"BazanS MileykovskayaE MallampalliVKPS HeacockP SparagnaGC DowhanW.Cardiolipin\u2010dependent reconstitution of respiratory supercomplexes from purifiedSaccharomyces cerevisiaecomplexes III and IV.2013;288:401\u2010411.","DOI":"10.1074\/jbc.M112.425876"},{"key":"e_1_2_15_129_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.367888"},{"key":"e_1_2_15_130_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M308366200"},{"key":"e_1_2_15_131_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M504955200"},{"key":"e_1_2_15_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2013.05.005"},{"key":"e_1_2_15_133_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201505644"},{"key":"e_1_2_15_134_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128561"},{"key":"e_1_2_15_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(90)80840-F"},{"key":"e_1_2_15_136_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.009037"},{"key":"e_1_2_15_137_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo9120306"},{"key":"e_1_2_15_138_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00336a001"},{"key":"e_1_2_15_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02056"},{"key":"e_1_2_15_140_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb0780"},{"key":"e_1_2_15_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(91)90235-Z"},{"key":"e_1_2_15_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)38309-7"},{"key":"e_1_2_15_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2728(90)90236-W"},{"key":"e_1_2_15_144_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2008.06216.x"},{"key":"e_1_2_15_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3545"},{"key":"e_1_2_15_146_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/654198"},{"key":"e_1_2_15_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2018.07.001"},{"key":"e_1_2_15_148_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.13973"},{"key":"e_1_2_15_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.09.057"},{"key":"e_1_2_15_150_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20081386"},{"key":"e_1_2_15_151_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2003.00335.x"},{"key":"e_1_2_15_152_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201210772"},{"key":"e_1_2_15_153_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1672"},{"key":"e_1_2_15_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2010.02.016"},{"key":"e_1_2_15_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.02.001"},{"key":"e_1_2_15_156_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00019.2006"},{"key":"e_1_2_15_157_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000156461.81529.D7"},{"key":"e_1_2_15_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2007.10.007"},{"key":"e_1_2_15_159_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.048698"},{"key":"e_1_2_15_160_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt032"},{"key":"e_1_2_15_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2012.07.015"},{"key":"e_1_2_15_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.07.008"},{"key":"e_1_2_15_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2004.09.026"},{"key":"e_1_2_15_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10234"},{"key":"e_1_2_15_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature17656"},{"key":"e_1_2_15_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09358"},{"key":"e_1_2_15_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.157"},{"key":"e_1_2_15_168_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1242993"},{"key":"e_1_2_15_169_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.41112"},{"key":"e_1_2_15_170_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0331-8"},{"key":"e_1_2_15_171_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-020-00776-w"},{"key":"e_1_2_15_172_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2000640117"},{"key":"e_1_2_15_173_1","first-page":"e201643748\u20102016","article-title":"High\u2010affinity cooperative Ca2+ binding by MICU1\u2013MICU2 serves as an on\u2013off switch for the uniporter","volume":"82","author":"Kamer KJ","year":"2017","journal-title":"EMBO Rep"},{"key":"e_1_2_15_174_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.968057"},{"key":"e_1_2_15_175_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000232546.92777.05"},{"key":"e_1_2_15_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.06.017"},{"key":"e_1_2_15_177_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1106291108"},{"key":"e_1_2_15_178_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3308"},{"key":"e_1_2_15_179_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.411363"},{"key":"e_1_2_15_180_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2008.163"},{"key":"e_1_2_15_181_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1219855"},{"key":"e_1_2_15_182_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.753574"},{"key":"e_1_2_15_183_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303356"},{"key":"e_1_2_15_184_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2119"},{"key":"e_1_2_15_185_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2012.24"},{"key":"e_1_2_15_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.09.023"},{"key":"e_1_2_15_187_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.032821"},{"key":"e_1_2_15_188_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2016.1240856"},{"key":"e_1_2_15_189_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2837"},{"key":"e_1_2_15_190_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9102333"},{"key":"e_1_2_15_191_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1023984"},{"key":"e_1_2_15_192_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.315956"},{"key":"e_1_2_15_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2006.07.011"},{"key":"e_1_2_15_194_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M200217-JLR200"},{"key":"e_1_2_15_195_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12461"},{"key":"e_1_2_15_196_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012121216"},{"key":"e_1_2_15_197_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2005.036657"},{"key":"e_1_2_15_198_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2012.92"},{"key":"e_1_2_15_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.04.016"},{"key":"e_1_2_15_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(86)90402-2"},{"key":"e_1_2_15_201_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-014-0119-3"},{"key":"e_1_2_15_202_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1091678"},{"key":"e_1_2_15_203_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003310"},{"key":"e_1_2_15_204_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.06.014"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jimd.12427","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jimd.12427","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jimd.12427","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T19:06:39Z","timestamp":1692817599000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jimd.12427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,9]]},"references-count":203,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/jimd.12427"],"URL":"https:\/\/doi.org\/10.1002\/jimd.12427","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,9]]},"assertion":[{"value":"2021-05-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}