{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:51:01Z","timestamp":1790682661841,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T00:00:00Z","timestamp":1643932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009908","name":"Grosserer L. F. Foghts Fond","doi-asserted-by":"publisher","award":["21.383"],"award-info":[{"award-number":["21.383"]}],"id":[{"id":"10.13039\/501100009908","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010809","name":"Jascha Fonden","doi-asserted-by":"publisher","award":["7715"],"award-info":[{"award-number":["7715"]}],"id":[{"id":"10.13039\/100010809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF17OC0027164"],"award-info":[{"award-number":["NNF17OC0027164"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","award":["18\u201010\u20100350"],"award-info":[{"award-number":["18\u201010\u20100350"]}],"id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The objective was to investigate whether resveratrol (RSV) can improve exercise capacity in patients with fatty acid oxidation (FAO) disorders. The study was a randomized, double\u2010blind, cross\u2010over trial. Nine patients with very long\u2010chain acyl\u2010CoA dehydrogenase (VLCAD) deficiency or carnitine palmitoyl transferase (CPT) II deficiency were randomized to receive either 8\u2009weeks of 1000\u2009mg\u2009day\n                    <jats:sup>\u22121<\/jats:sup>\n                    RSV or placebo (P) followed by a 4\u2010weeks wash\u2010out period and subsequently 8\u2009weeks of the opposite treatment. Primary outcome measures were heart rate and FAO as measured via stable isotope technique during constant workload exercise. Secondary outcome measures included fat and glucose metabolism; perceived exertion; as well as subjective measures of energy expenditure, fatigue, and daily function. Eight participants completed the trial. Heart rate did not differ at the end of exercise after treatment with RSV vs placebo (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.063). Rate of oxidation of palmitate at end of exercise was not different with 1.5\u2009\u00b1\u20090.8 (RSV) vs 1.3\u2009\u00b1\u20090.6 (P) \u03bcmol\u2009kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00a0min\n                    <jats:sup>\u22121<\/jats:sup>\n                    (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.109). Secondary outcomes did not change except for increased plasma glycerol and decreased plasma glucose levels at the end of exercise after treatment with RSV vs placebo. A daily dose of 1000\u2009mg resveratrol does not improve exercise capacity or FAO during exercise in patients with CPTII or VLCAD deficiencies.\n                  <\/jats:p>","DOI":"10.1002\/jimd.12479","type":"journal-article","created":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T05:44:11Z","timestamp":1642916651000},"page":"517-528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["No effect of resveratrol on fatty acid oxidation or exercise capacity in patients with fatty acid oxidation disorders: A randomized clinical cross\u2010over trial"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0900-4908","authenticated-orcid":false,"given":"Jesper H.","family":"Storgaard","sequence":"first","affiliation":[{"name":"Copenhagen Neuromuscular Center, Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoline","family":"L\u00f8kken","sequence":"additional","affiliation":[{"name":"Copenhagen Neuromuscular Center, Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Madsen","sequence":"additional","affiliation":[{"name":"Copenhagen Neuromuscular Center, Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol C.","family":"Voermans","sequence":"additional","affiliation":[{"name":"Department of Neurology Radboud University Nijmegen Medical Centre  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Lafor\u00eat","sequence":"additional","affiliation":[{"name":"Nord\/Est\/Ile de France Neuromuscular Reference Center, FHU PHENIX, INSERM U1179, Neurology Department, Raymond\u2010Poincar\u00e9 Teaching Hospital Garches, AP\u2010HP, Paris Saclay University  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Nadaj\u2010Pakleza","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence des Maladies Neuromusculaires Nord \/ Est \/ Ile\u2010de\u2010France, Service de Neurologie, H\u00f4pitaux Universitaires de Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Tard","sequence":"additional","affiliation":[{"name":"Centre de r\u00e9f\u00e9rence des maladies rares neuromusculaires, Nord Est Ile de France, U1171, H\u00f4pital Salengro, CRU de Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerrit","family":"van Hall","sequence":"additional","affiliation":[{"name":"Clinical Metabolomics Core Facility, Clinical Biochemistry, Righospitalet &amp; Department of Biomedical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Vissing","sequence":"additional","affiliation":[{"name":"Copenhagen Neuromuscular Center, Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette C.","family":"\u00d8rngreen","sequence":"additional","affiliation":[{"name":"Copenhagen Neuromuscular Center, Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,4]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"GeneReviews\u00ae","author":"Leslie ND","year":"2020"},{"key":"e_1_2_7_3_1","volume-title":"GeneReviews(\u00ae)","author":"Wieser T","year":"2020"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20168"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20320"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000078195.05396.20"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2020.10.001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.37765\/ajmc.2020.88480"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jimd.12199"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000118"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr089"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-9-79"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23010007"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-014-1808-8"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy403"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2060"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21565"},{"key":"e_1_2_7_18_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.2340\/1650197719702239298","article-title":"Perceived exertion as an indicator of somatic stress","volume":"2","author":"Borg G","year":"1970","journal-title":"Scand J Rehabil Med"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(81)90074-3"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000183344.46077.bb"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2012.12.013"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmd2.12113"},{"key":"e_1_2_7_24_1","volume-title":"Isotope Tracers in Metabolic Research. Principles and Practice of Kinetic Analysis","author":"Wolfe RR","year":"2005"},{"issue":"2","key":"e_1_2_7_25_1","first-page":"A463","article-title":"Impaired fat oxidation in adult carnitine palmitoyltransferase II deficiency is specific to exercise","volume":"52","author":"Haller RG","year":"1999","journal-title":"Neurology"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-77197-6"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glx089"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.258061"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2013-0547"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.270256"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2014-0070"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21062084"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200500010"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/837042"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2799"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23006"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-2364"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.2165\/11531820-000000000-00000"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-017-0085-8"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jimd.12479","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jimd.12479","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jimd.12479","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T04:02:25Z","timestamp":1692763345000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jimd.12479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,4]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1002\/jimd.12479"],"URL":"https:\/\/doi.org\/10.1002\/jimd.12479","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,4]]},"assertion":[{"value":"2021-10-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}