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The TLR9 activation prompted us to treat patients with corticosteroids in acute conditions. In patients with <jats:italic>LPIN1<\/jats:italic> mutations, RM and at\u2010risk situations that can trigger RM have been treated in a uniform manner. Since 2015, these patients have also received intravenous corticosteroids. We retrospectively compared data on hospital stays by corticosteroid\u2010treated patients vs. patients not treated with corticosteroids. Nineteen patients were hospitalized. The median number of admissions per patient was 21 overall and did not differ when comparing the 10 corticosteroid\u2010treated patients with the 9 patients not treated with corticosteroids. Four patients in the non\u2010corticosteroid group died during a RM (mean age at death: 5.6\u2009years). There were no deaths in the corticosteroid group. The two groups did not differ significantly in the number of RM episodes. However, for the six patients who had RM and occasionally been treated with corticosteroids, the median number of RM episodes was significantly lower when intravenous steroids had been administered. The peak plasma creatine kinase level and the area under the curve were or tended to be higher in patients treated with corticosteroids\u2014even after the exclusion of deceased patients or focusing on the period after 2015. The median length of stay (10\u2009days overall) was significantly longer for corticosteroid\u2010treated patients but was similar after the exclusion of deceased patients. The absence of deaths and the higher severity of RM observed among corticosteroid\u2010treated patients could suggest that corticotherapy is associated with greater survival.<\/jats:p>","DOI":"10.1002\/jimd.12592","type":"journal-article","created":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T14:54:33Z","timestamp":1674312873000},"page":"649-661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Systemic corticosteroids for the treatment of acute episodes of rhabdomyolysis in lipin\u20101\u2010deficient patients"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5636-6998","authenticated-orcid":false,"given":"Caroline","family":"Tuchmann\u2010Durand","sequence":"first","affiliation":[{"name":"Imagine Institute, Biotherapy Clinical Investigation Center, Biotherapy Department Necker\u2010Enfants\u2010Malades University Hospital, Assistance Publique\u2010H\u00f4pitaux de Paris 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