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From a value\u2010based healthcare (VBHC) perspective, we here retrospectively studied patient\u2010reported, clinical and pharmacoeconomic outcomes in 11 GSDIb individuals before and under empagliflozin at two centers (the Netherlands [NL], Austria [AT]), including a budget impact analysis, sensitivity\u2010analysis, and systematic benefit\u2013risk assessment. Under empagliflozin, all GSDIb individuals reported improved quality\u2010of\u2010life\u2010scores. Neutrophil dysfunction related symptoms allowed either granulocyte colony\u2010stimulating factor cessation or tapering. Calculated cost savings per patient per year ranged between \u20ac 6482\u201314\u2009190 (NL) and \u20ac 1281\u201341\u2009231 (AT). The budget impact analysis estimated annual total cost savings ranging between \u20ac 75\u2009062\u2013225\u2009716 (NL) and \u20ac 37\u2009697\u2013231\u2009790 (AT), based on conservative assumptions. The systematic benefit\u2010risk assessment was favorable. From a VBHC perspective, empagliflozin treatment in GSDIb improved personal and clinical outcomes while saving costs, thereby creating value at multiple pillars. We emphasize the importance to reimburse empagliflozin for GSDIb individuals, further supported by the favorable systematic benefit\u2010risk assessment. These observations in similar directions in two countries\/health care systems strongly suggest that our findings can be extrapolated to other geographical areas and health care systems.<\/jats:p>","DOI":"10.1002\/jimd.12714","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T06:08:24Z","timestamp":1704694104000},"page":"244-254","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Repurposing empagliflozin in individuals with glycogen storage disease Ib: A value\u2010based healthcare approach and systematic benefit\u2010risk assessment"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7259-1095","authenticated-orcid":false,"given":"Terry G. 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