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The pace of development has not kept up with the increasing demands of the \u2018real world\u2019 or development in other areas of medicine. It is essential that research and advancements in nutrition therapy proceed to the next level in order to improve long\u2010term outcomes and the quality of life for patients. Future nutrition innovation should be fuelled by potential advancements in technology, such as precision fermentation, predictive analytics, artificial intelligence and personalized therapies determined by genetic profile. There is a need to re\u2010examine the nutritional composition and delivery of formulations used in IEPM. New pharmaceutical treatments are expected to enhance natural protein intake, lead to sustained healthy dietary patterns and ease diet\u2010related management. However, their administration requires careful patient re\u2010education and monitoring to ensure the non\u2010adoption of inappropriate eating habits associated with excess weight gain and increased risk of metabolic syndrome. Generally, careful longitudinal assessment is the most indicative measure of nutritional adequacy in all IEPM and this is central to monitoring the impact of any dietary innovation. In the future, for some of the amino disorders such as phenylketonuria, point of care monitoring devices are expected to revolutionise the way we monitor blood amino acid levels. However, all new technologies come with risk and safety issues so careful research and assessment prior to implementation in patient care is necessary.<\/jats:p>","DOI":"10.1002\/jimd.70123","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T04:48:42Z","timestamp":1765342122000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["From Control to Optimisation: Evolving Strategies in the Nutritional Management of Inborn Errors of Protein Metabolism"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4977-8345","authenticated-orcid":false,"given":"J\u00falio C\u00e9sar","family":"Rocha","sequence":"first","affiliation":[{"name":"Nutrition and Metabolism, NOVA Medical School (NMS), Faculdade de Ci\u00eancias M\u00e9dicas (FCM), Universidade Nova de Lisboa  Lisboa Portugal"},{"name":"CINTESIS@RISE, Nutrition and Metabolism, NOVA Medical School (NMS), Faculdade de Ci\u00eancias M\u00e9dicas, (FCM), Universidade NOVA de Lisboa  Lisboa Portugal"},{"name":"Reference Center of Inherited Metabolic Diseases Unidade Local de Sa\u00fade de S\u00e3o Jos\u00e9  Lisboa Portugal"},{"name":"Comprehensive Health Research Centre (CHRC), NOVA Medical School|Faculdade de Ci\u00eancias M\u00e9dicas, NMS|FCM Universidade Nova de Lisboa  Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Daly","sequence":"additional","affiliation":[{"name":"Birmingham Women's and Children's Hospital  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Birmingham Women's and Children's Hospital  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"key":"e_1_2_20_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020484"},{"key":"e_1_2_20_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jimd.12719"},{"issue":"1","key":"e_1_2_20_4_1","article-title":"Exploring the Impact of Macronutrients on Cellular Processes","volume":"8","author":"Worqlul T.","year":"2024","journal-title":"Insights Nutrition and Metabolism"},{"key":"e_1_2_20_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2023.02.005"},{"key":"e_1_2_20_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16070956"},{"key":"e_1_2_20_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2022.09.012"},{"key":"e_1_2_20_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat7992"},{"key":"e_1_2_20_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01556-3"},{"key":"e_1_2_20_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-025-02548-x"},{"key":"e_1_2_20_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5FO01530H"},{"key":"e_1_2_20_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0205-1"},{"key":"e_1_2_20_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11091990"},{"key":"e_1_2_20_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954422424000271"},{"key":"e_1_2_20_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14030453"},{"key":"e_1_2_20_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.06.010"},{"key":"e_1_2_20_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10091179"},{"key":"e_1_2_20_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.08.001"},{"key":"e_1_2_20_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2023.112953"},{"key":"e_1_2_20_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2025.2465896"},{"key":"e_1_2_20_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114524000734"},{"key":"e_1_2_20_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954422423000124"},{"key":"e_1_2_20_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12082457"},{"key":"e_1_2_20_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.26.14930"},{"key":"e_1_2_20_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqaa112"},{"issue":"7","key":"e_1_2_20_26_1","first-page":"42","article-title":"Mycoprotein\u2010 a Meat Alternative New to the U.S.","volume":"55","author":"Biswas A. 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