{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:45:28Z","timestamp":1780058728347,"version":"3.54.0"},"reference-count":73,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5,23]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Invariant NK T (iNKT) cells are innate-like lymphocytes that can recognize the lipid Ag presented by MHC I like molecule CD1d. Distinct tissue distribution of iNKT cells subsets implies a contribution of these subsets to their related tissue regional immunity. iNKT cells are enriched in liver, an organ with unique immunological properties. Whether liver-specific iNKT cells exist and dedicate to the liver immunity remains elusive. Here, a liver-specific CD24+ iNKT subset is shown. Hepatic CD24+ iNKT cells show higher levels of proliferation, glucose metabolism, and mTOR activity comparing to CD24\u2013 iNKT cells. Although CD24+ iNKT cells and CD24\u2013 iNKT cells in the liver produce similar amounts of cytokines, the hepatic CD24+ iNKT cells exhibit lower granzyme B production. These liver-specific CD24+ iNKT cells are derived from thymus and differentiate into CD24+ iNKT in the liver microenvironment. Moreover, liver microenvironment induces the formation of CD24+ conventional T cells as well, and these cells exhibit higher proliferation ability but lower granzyme B production in comparison with CD24\u2013 T cells. The results propose that liver microenvironment might induce the generation of liver-specific iNKT subset that might play an important role in maintaining liver homeostasis.<\/jats:p>","DOI":"10.1002\/jlb.1a0621-309r","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T11:26:36Z","timestamp":1635938796000},"page":"1199-1210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Identification of liver-specific CD24+ invariant NK T cells with low granzyme B production and high proliferative capacity"],"prefix":"10.1093","volume":"111","author":[{"given":"Xiang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xihua","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qielan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,11,3]]},"reference":[{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev.immunol.25.022106.141711","article-title":"The biology of NKT cells","volume":"25","author":"Bendelac","year":"2007","journal-title":"Annu Rev Immunol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev-immunol-032713-120243","article-title":"Biology of CD1- and MR1-restricted T cells","volume":"32","author":"Salio","year":"2014","journal-title":"Annu Rev Immunol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nri3369","article-title":"Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions","volume":"13","author":"Brennan","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.cell.2016.02.048","article-title":"Hallmarks of Tissue-Resident Lymphocytes","volume":"164","author":"Fan","year":"2016","journal-title":"Cell"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/ni.3437","article-title":"Innate-like functions of natural killer T cell subsets result from highly divergent gene programs","volume":"17","author":"Engel","year":"2016","journal-title":"Nat Immunol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.4049\/jimmunol.1102414","article-title":"Distinct APCs explain the cytokine bias of alpha-galactosylceramide variants in vivo","volume":"188","author":"Bai","year":"2012","journal-title":"J Immunol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.immuni.2013.12.004","article-title":"A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens","volume":"40","author":"Arora","year":"2014","journal-title":"Immunity"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1007\/s11427-016-0348-7","article-title":"Lactic acid in tumor microenvironments causes dysfunction of NKT cells by interfering with mTOR signaling","volume":"59","author":"Xie","year":"2016","journal-title":"Sci China Life Sci"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aau1788","article-title":"Immunometabolism regulates TCR recycling and iNKT cell functions","author":"Fu","year":"2019","journal-title":"Sci Signal"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/s41577-018-0034-2","article-title":"Tissue-specific functions of invariant natural killer T cells","volume":"18","author":"Crosby","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/ni.1841","article-title":"Raising the NKT cell family","volume":"11","author":"Godfrey","year":"2010","journal-title":"Nat Immunol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1084\/jem.20061551","article-title":"Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia","volume":"204","author":"Michel","year":"2007","journal-title":"J Exp Med"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"e1001255","DOI":"10.1371\/journal.pbio.1001255","article-title":"Development and function of invariant natural killer T cells producing T(h)2- and T(h)17-cytokines","volume":"10","author":"Watarai","year":"2012","journal-title":"PLoS Biol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.4049\/jimmunol.0901059","article-title":"Skin and peripheral lymph node invariant NKT cells are mainly retinoic acid receptor-related orphan receptor (gamma)t+ and respond preferentially under inflammatory conditions","volume":"183","author":"Doisne","year":"2009","journal-title":"J Immunol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev-immunol-051116-052415","article-title":"Immune Responses in the Liver","volume":"36","author":"Kubes","year":"2018","journal-title":"Annu Rev Immunol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","DOI":"10.1038\/cmi.2017.72","article-title":"Liver-resident NK cells and their potential functions","author":"Peng","year":"2017","journal-title":"Cell Mol Immunol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nri.2017.11","article-title":"Liver macrophages in tissue homeostasis and disease","volume":"17","author":"Krenkel","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.immuni.2016.08.011","article-title":"Liver-Resident Memory CD8(+) T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection","volume":"45","author":"Fernandez-Ruiz","year":"2016","journal-title":"Immunity"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/cmi.2015.115","article-title":"NKT cell subsets as key participants in liver physiology and pathology","volume":"13","author":"Bandyopadhyay","year":"2016","journal-title":"Cellular & Molecular Immunology"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/cmi.2009.119","article-title":"CD24: from A to Z","volume":"7","author":"Fang","year":"2010","journal-title":"Cell Mol Immunol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1126\/science.1069017","article-title":"A thymic precursor to the NK T cell lineage","volume":"296","author":"Benlagha","year":"2002","journal-title":"Science"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1084\/jem.182.6.2091","article-title":"Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes","volume":"182","author":"Bendelac","year":"1995","journal-title":"J Exp Med"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/ni710","article-title":"NKT cells derive from double-positive thymocytes that are positively selected by CD1d","volume":"2","author":"Gapin","year":"2001","journal-title":"Nat Immunol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1126\/science.278.5343.1623","article-title":"Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors","volume":"278","author":"Cui","year":"1997","journal-title":"Science"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S1074-7613(00)80290-3","article-title":"CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4","volume":"6","author":"Mendiratta","year":"1997","journal-title":"Immunity"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.4049\/jimmunol.1501222","article-title":"Antigen Specificity of Type I NKT Cells Is Governed by TCR beta-Chain Diversity","volume":"195","author":"Cameron","year":"2015","journal-title":"J Immunol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.immuni.2009.05.010","article-title":"T cell receptor CDR2 beta and CDR3 beta loops collaborate functionally to shape the iNKT cell repertoire","volume":"31","author":"Mallevaey","year":"2009","journal-title":"Immunity"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"6335","DOI":"10.4049\/jimmunol.1003965","article-title":"IL-15 regulates homeostasis and terminal maturation of NKT cells","volume":"187","author":"Gordy","year":"2011","journal-title":"J Immunol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1073\/pnas.1219242110","article-title":"Interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations","volume":"110","author":"Tani-ichi","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"4444","DOI":"10.4049\/jimmunol.1201181","article-title":"Role of hepatocyte-derived IL-7 in maintenance of intrahepatic NKT cells and T cells and development of B cells in fetal liver","volume":"189","author":"Liang","year":"2012","journal-title":"J Immunol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1172\/JCI200423594","article-title":"Going both ways: immune regulation via CD1d-dependent NKT cells","volume":"114","author":"Godfrey","year":"2004","journal-title":"J Clin Invest"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1146\/annurev.immunol.23.021704.115742","article-title":"Toward an understanding of NKT cell biology: progress and paradoxes","volume":"23","author":"Kronenberg","year":"2005","journal-title":"Annu Rev Immunol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1126\/science.278.5343.1626","article-title":"CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides","volume":"278","author":"Kawano","year":"1997","journal-title":"Science"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1084\/jem.191.1.105","article-title":"Augmentation of Valpha14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis","volume":"191","author":"Kaneko","year":"2000","journal-title":"J Exp Med"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/ni.2393","article-title":"Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation","volume":"13","author":"van Gisbergen","year":"2012","journal-title":"Nat Immunol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"12841","DOI":"10.1073\/pnas.1323405111","article-title":"CD1d-unrestricted NKT cells are endowed with a hybrid function far superior than that of iNKT cells","volume":"111","author":"Farr","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/path.1950","article-title":"Adoptive transfer of regulatory NKT lymphocytes ameliorates non-alcoholic steatohepatitis and glucose intolerance in ob\/ob mice and is associated with intrahepatic CD8 trapping","volume":"209","author":"Elinav","year":"2006","journal-title":"J Pathol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1084\/jem.20040779","article-title":"CD24 expression on T cells is required for optimal T cell proliferation in lymphopenic host","volume":"200","author":"Li","year":"2004","journal-title":"J Exp Med"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41577-019-0203-y","article-title":"Metabolic coordination of T cell quiescence and activation","volume":"20","author":"Chapman","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1158\/2326-6066.CIR-17-0605","article-title":"Hallmarks of T-cell Exit from Quiescence","volume":"6","author":"Chapman","year":"2018","journal-title":"Cancer Immunol Res"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41580-019-0199-y","article-title":"mTOR at the nexus of nutrition, growth, ageing and disease","volume":"21","author":"Liu","year":"2020","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.coi.2013.05.002","article-title":"mTOR and lymphocyte metabolism","volume":"25","author":"Zeng","year":"2013","journal-title":"Curr Opin Immunol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","article-title":"mTOR signaling in growth control and disease","volume":"149","author":"Laplante","year":"2012","journal-title":"Cell"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"223","DOI":"10.4049\/jimmunol.1401985","article-title":"Mammalian target of rapamycin complex 2 regulates invariant NKT cell development and function independent of promyelocytic leukemia zinc-finger","volume":"194","author":"Prevot","year":"2015","journal-title":"J Immunol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"E776","DOI":"10.1073\/pnas.1315435111","article-title":"Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function","volume":"111","author":"Shin","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41580-018-0089-8","article-title":"Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins","volume":"20","author":"Singh","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ni740","article-title":"Multiple defects in antigen presentation and T cell development by mice expressing cytoplasmic tail-truncated CD1d","volume":"3","author":"Chiu","year":"2002","journal-title":"Nat Immunol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/357161a0","article-title":"Profound block in thymocyte development in mice lacking p56lck","volume":"357","author":"Molina","year":"1992","journal-title":"Nature"},{"key":"2023032108504940900_","article-title":"Gut microbiota in human metabolic health and disease","author":"Fan","year":"2020","journal-title":"Nat Rev Microbiol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jhep.2019.10.003","article-title":"The gut-liver axis in liver disease: pathophysiological basis for therapy","volume":"72","author":"Albillos","year":"2020","journal-title":"J Hepatol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan5931","article-title":"Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells","author":"Ma","year":"2018","journal-title":"Science"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.3389\/fimmu.2018.02398","article-title":"Peripheral Dopamine Controlled by Gut Microbes Inhibits Invariant Natural Killer T Cell-Mediated Hepatitis","volume":"9","author":"Xue","year":"2018","journal-title":"Front Immunol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"S565","DOI":"10.1093\/cid\/ciz830","article-title":"Treatment Options for Carbapenem-resistant Gram-negative Bacterial Infections","volume":"69","author":"Doi","year":"2019","journal-title":"Clin Infect Dis"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev.immunol.021908.132629","article-title":"The Liver as a Lymphoid Organ","volume":"27","author":"Crispe","year":"2009","journal-title":"Annual Review of Immunology"},{"key":"2023032108504940900_","article-title":"Gut microbial metabolites as multi-kingdom intermediates","author":"Krautkramer","year":"2020","journal-title":"Nat Rev Microbiol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/ni.2691","article-title":"Immune surveillance by the liver","volume":"14","author":"Jenne","year":"2013","journal-title":"Nat Immunol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrgastro.2015.200","article-title":"Immunology in the liver\u2013from homeostasis to disease","volume":"13","author":"Heymann","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2023032108504940900_","article-title":"Innate lymphocytes: pathogenesis and therapeutic targets of liver diseases and cancer","author":"Chen","year":"2020","journal-title":"Cell Mol Immunol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.immuni.2018.03.009","article-title":"Unconventional T Cell Targets for Cancer Immunotherapy","volume":"48","author":"Godfrey","year":"2018","journal-title":"Immunity"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.immuni.2012.06.016","article-title":"Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production","volume":"37","author":"Lynch","year":"2012","journal-title":"Immunity"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/ni.3047","article-title":"Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue","volume":"16","author":"Lynch","year":"2015","journal-title":"Nat Immunol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cmet.2020.05.017","article-title":"Distinct iNKT Cell Populations Use IFNgamma or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis","volume":"32","author":"LaMarche","year":"2020","journal-title":"Cell Metab"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"5498","DOI":"10.1073\/pnas.040566697","article-title":"Critical contribution of liver natural killer T cells to a murine model of hepatitis","volume":"97","author":"Takeda","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"9054","DOI":"10.1073\/pnas.1920463117","article-title":"Combined proinflammatory cytokine and cognate activation of invariant natural killer T cells enhances anti-DNA antibody responses","volume":"117","author":"Sedimbi","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"E1143","DOI":"10.1073\/pnas.1200498109","article-title":"Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice","volume":"109","author":"Wu","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"28473","DOI":"10.1038\/srep28473","article-title":"Adipocyte-specific CD1d-deficiency mitigates diet-induced obesity and insulin resistance in mice","volume":"6","author":"Satoh","year":"2016","journal-title":"Sci Rep"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/ni.2731","article-title":"Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells","volume":"14","author":"Lee","year":"2013","journal-title":"Nat Immunol"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1053\/j.gastro.2012.04.017","article-title":"Intestinal microbes affect phenotypes and functions of invariant natural killer T cells in mice","volume":"143","author":"Wingender","year":"2012","journal-title":"Gastroenterology"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.immuni.2015.06.025","article-title":"Tissue-Specific Distribution of iNKT Cells Impacts Their Cytokine Response","volume":"43","author":"Lee","year":"2015","journal-title":"Immunity"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.51663","article-title":"Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells","volume":"8","author":"Jimeno","year":"2019","journal-title":"Elife"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1172\/JCI83476","article-title":"CD62L+ NKT cells have prolonged persistence and antitumor activity in vivo","volume":"126","author":"Tian","year":"2016","journal-title":"J Clin Invest"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1084\/jem.177.5.1399","article-title":"Extrathymic development of V alpha 14-positive T cells","volume":"177","author":"Makino","year":"1993","journal-title":"J Exp Med"},{"key":"2023032108504940900_","doi-asserted-by":"crossref","first-page":"10783","DOI":"10.1158\/0008-5472.CAN-05-0619","article-title":"CD24 expression causes the acquisition of multiple cellular properties associated with tumor growth and metastasis","volume":"65","author":"Baumann","year":"2005","journal-title":"Cancer Res"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JLB.1A0621-309R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/JLB.1A0621-309R","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/111\/6\/1199\/49467557\/jlb11037.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/111\/6\/1199\/49467557\/jlb11037.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T06:03:33Z","timestamp":1699769013000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/111\/6\/1199\/6885207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,3]]},"references-count":73,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,11,3]]},"published-print":{"date-parts":[[2022,5,23]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.1a0621-309r","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,6]]},"published":{"date-parts":[[2021,11,3]]},"assertion":[{"value":"2021-11-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}