{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T10:00:32Z","timestamp":1781776832735,"version":"3.54.5"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thymocyte differentiation and lineage commitment is regulated by an extensive network of transcription factors and signaling molecules among which Erk plays a central role. However, Erk effectors as well as the molecular mechanisms underlying this network are not well understood. Erf is a ubiquitously expressed transcriptional repressor regulated by Erk-dependent phosphorylation. Here, we investigated the role of Erf in T cell maturation and lineage commitment, using a double-fluorescent Erf-floxed mouse to produce thymus-specific Erf knockouts. We observed significant accumulation of thymocytes in the CD4\/CD8 DP stage, followed by a significant reduction in CD4SP cells, a trend for lower CD8SP cell frequency, and an elevated percentage of \u03b3\u03b4 expressing thymocytes in Erf-deficient mice. Also, an elevated number of CD69+TCR\u03b2+ cells indicates that thymocytes undergoing positive selection accumulate at this stage. The expression of transcription factors Gata3, ThPOK, and Socs1 that promote CD4+ cell commitment was significantly decreased in Erf-deficient mice. These findings suggest that Erf is involved in T cell maturation, acting as a positive regulator during CD4 and eventually CD8 lineage commitment, while negatively regulates the production of \u03b3\u03b4 T cells. In addition, Erf-deficient mice displayed decreased percentages of CD4+ and CD8+ splenocytes and elevated levels of IL-4 indicating that Erf may have an additional role in the homeostasis, differentiation, and immunologic response of helper and cytotoxic T cells in the periphery. Overall, our results show, for the first time, Erf's involvement in T cell biology suggesting that Erf acts as a potential regulator during thymocyte maturation and thymocyte lineage commitment, in \u03b3\u03b4 T cell generation, as well as in Th cell differentiation.<\/jats:p>","DOI":"10.1002\/jlb.1a0720-439r","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T10:18:49Z","timestamp":1646734729000},"page":"641-657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["ETS2 repressor factor (ERF) is involved in T lymphocyte maturation acting as regulator of thymocyte lineage commitment"],"prefix":"10.1093","volume":"112","author":[{"given":"Spyridoula","family":"Tsiomita","sequence":"first","affiliation":[{"name":"Department of Biological Applications and Technology, University of Ioannina , Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Effrosyni Maria","family":"Liveri","sequence":"additional","affiliation":[{"name":"Department of Biological Applications and Technology, University of Ioannina , Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiota","family":"Vardaka","sequence":"additional","affiliation":[{"name":"Department of Biological Applications and Technology, University of Ioannina , Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeliki","family":"Vogiatzi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Medical School, University of Crete , Heraklion, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argyris","family":"Skiadaresis","sequence":"additional","affiliation":[{"name":"Department of Biological Applications and Technology, University of Ioannina , Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Saridis","sequence":"additional","affiliation":[{"name":"Department of Biological Applications and Technology, University of Ioannina , Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Tsigkas","sequence":"additional","affiliation":[{"name":"Department of Biological Applications and Technology, University of Ioannina , Ioannina, Greece"},{"name":"Department of Biomedical Research, Institute of Molecular Biology & Biotechnology, Foundation for Research and Technology-Hellas , Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theologos M","family":"Michaelidis","sequence":"additional","affiliation":[{"name":"Department of Biological Applications and Technology, University of Ioannina , Ioannina, Greece"},{"name":"Department of Biomedical Research, Institute of Molecular Biology & Biotechnology, Foundation for Research and Technology-Hellas , Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Mavrothalassitis","sequence":"additional","affiliation":[{"name":"Department of Medicine, Medical School, University of Crete , Heraklion, Greece"},{"name":"IMBB, FORTH , Heraklion, Crete, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Thyphronitis","sequence":"additional","affiliation":[{"name":"Department of Biological Applications and Technology, University of Ioannina , Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,8]]},"reference":[{"issue":"9","key":"2023032107573047500_","doi-asserted-by":"crossref","first-page":"4017 LP","DOI":"10.4049\/jimmunol.1302259","article-title":"An overview of the intrathymic intricacies of T cell development","volume":"192","author":"Shah","year":"2014","journal-title":"J 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