{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:44:10Z","timestamp":1764996250436,"version":"3.37.3"},"reference-count":178,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T00:00:00Z","timestamp":1581984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T00:00:00Z","timestamp":1581984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T00:00:00Z","timestamp":1581984000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cutting-edge questions in \u03b1\u03b2 T cell biology were addressed by investigating a range of different genetically modified mouse models. In comparison, the \u03b3\u03b4 T cell field lacks behind on the availability of such models. Nevertheless, transgenic mouse models proved useful for the investigation of \u03b3\u03b4 T cell biology and their stepwise development in the thymus. In general, animal models and especially mouse models give access to a wide range of opportunities of modulating \u03b3\u03b4 T cells, which is unachievable in human beings. Because of their complex biology and specific tissue tropism, it is especially challenging to investigate \u03b3\u03b4 T cells in in vitro experiments since they might not reliably reflect their behavior and phenotype under physiologic conditions. This review aims to provide a comprehensive historical overview about how different transgenic mouse models contributed in regards of the understanding of \u03b3\u03b4 T cell biology, whereby a special focus is set on studies including the elusive role of the \u03b3\u03b4TCR. Furthermore, evolutionary and translational remarks are discussed under the aspect of future implications for the field. The ultimate full understanding of \u03b3\u03b4 T cells will pave the way for their usage as a powerful new tool in immunotherapy.<\/jats:p>","DOI":"10.1002\/jlb.1mr0120-237r","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T12:13:52Z","timestamp":1582028032000},"page":"993-1007","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Resolving the mystery\u2014How TCR transgenic mouse models shed light on the elusive case of gamma delta T cells"],"prefix":"10.1093","volume":"107","author":[{"given":"Anne M.","family":"Hahn","sequence":"first","affiliation":[{"name":"Department of Biology, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) , Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1860-0528","authenticated-orcid":false,"given":"Thomas H.","family":"Winkler","sequence":"additional","affiliation":[{"name":"Department of Biology, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) , Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,2,18]]},"reference":[{"key":"2023012312520816500_jlb10563-bib-0001","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/312036a0","article-title":"A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes","volume":"312","author":"Hayday","year":"1984","journal-title":"Nature"},{"key":"2023012312520816500_jlb10563-bib-0002","doi-asserted-by":"crossref","first-page":"309757a0","DOI":"10.1038\/309757a0","article-title":"Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences","volume":"309","author":"Saito","year":"1984","journal-title":"Nature"},{"key":"2023012312520816500_jlb10563-bib-0003","doi-asserted-by":"crossref","first-page":"322145a0","DOI":"10.1038\/322145a0","article-title":"Identification of a putative second T-cell receptor","volume":"322","author":"Brenner","year":"1986","journal-title":"Nature"},{"key":"2023012312520816500_jlb10563-bib-0004","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/312031a0","article-title":"A third type of murine T-cell receptor gene","volume":"312","author":"Chien","year":"1984","journal-title":"Nature"},{"key":"2023012312520816500_jlb10563-bib-0005","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1126\/science.3787252","article-title":"Characterization of T cell receptor gamma chain expression in a subset of murine thymocytes","volume":"234","author":"Lew","year":"1986","journal-title":"Science"},{"key":"2023012312520816500_jlb10563-bib-0006","doi-asserted-by":"crossref","first-page":"334395a0","DOI":"10.1038\/334395a0","article-title":"T-cell antigen receptor genes and T-cell recognition","volume":"334","author":"Davis","year":"1988","journal-title":"Nature"},{"key":"2023012312520816500_jlb10563-bib-0007","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/s41590-018-0304-y","article-title":"\u03b3\u03b4 TCR ligands: the quest to solve a 500-million-year-old mystery","volume":"20","author":"Willcox","year":"2019","journal-title":"Nat Immunol"},{"key":"2023012312520816500_jlb10563-bib-0008","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nri797","article-title":"\u03b3\u03b4 T cells: functional plasticity and heterogeneity","volume":"2","author":"Carding","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"2023012312520816500_jlb10563-bib-0009","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nature12467","article-title":"Evolutionary implications of a third lymphocyte lineage in lampreys","volume":"501","author":"Hirano","year":"2013","journal-title":"Nature"},{"key":"2023012312520816500_jlb10563-bib-0010","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0092-8674(94)90169-4","article-title":"T cell receptor antagonist peptides induce positive selection","volume":"76","author":"Hogquist","year":"1994","journal-title":"Cell"},{"key":"2023012312520816500_jlb10563-bib-0011","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0952-7915(94)90101-5","article-title":"The ligand for positive selection of T lymphocytes in the thymus","volume":"6","author":"Hogquist","year":"1994","journal-title":"Curr Opin Immunol"},{"key":"2023012312520816500_jlb10563-bib-0012","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/365053a0","article-title":"Different roles of \u03b1\u03b2 and \u03b3\u03b4 T cells in immunity against an intracellular bacterial pathogen","volume":"365","author":"Mombaerts","year":"1993","journal-title":"Nature"},{"key":"2023012312520816500_jlb10563-bib-0013","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0092-8674(93)90112-4","article-title":"T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes","volume":"72","author":"Itohara","year":"1993","journal-title":"Cell"},{"key":"2023012312520816500_jlb10563-bib-0014","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.coi.2009.12.006","article-title":"Alphabeta versus gammadelta lineage choice at the first TCR-controlled checkpoint","volume":"22","author":"Kreslavsky","year":"2010","journal-title":"Curr Opin Immunol"},{"key":"2023012312520816500_jlb10563-bib-0015","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/360225a0","article-title":"Mutations in T-cell antigen receptor genes \u03b1 and \u03b2 block thymocyte development at different stages","volume":"360","author":"Mombaerts","year":"1992","journal-title":"Nature"},{"key":"2023012312520816500_jlb10563-bib-0016","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0960-9822(95)00131-X","article-title":"Alpha beta and gamma delta T cells can share a late common precursor","volume":"5","author":"Dudley","year":"1995","journal-title":"Curr Biol"},{"key":"2023012312520816500_jlb10563-bib-0017","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1093\/intimm\/11.10.1641","article-title":"Unexpectedly late expression of intracellular CD3epsilon and TCR gammadelta proteins during adult thymus development","volume":"11","author":"Wilson","year":"1999","journal-title":"Int Immunol"},{"key":"2023012312520816500_jlb10563-bib-0018","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1074-7613(00)80512-9","article-title":"Intrathymic delta selection events in gammadelta cell development","volume":"7","author":"Passoni","year":"1997","journal-title":"Immunity"},{"key":"2023012312520816500_jlb10563-bib-0019","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev.iy.06.040188.001521","article-title":"The developmental biology of T lymphocytes","volume":"6","author":"Boehmer","year":"1988","journal-title":"Annu Rev Immunol"},{"key":"2023012312520816500_jlb10563-bib-0020","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1002\/eji.1830220836","article-title":"Commitment to the T cell receptor-alpha beta or -gamma delta lineages can occur just prior to the onset of CD4 and CD8 expression among immature thymocytes","volume":"22","author":"Petrie","year":"1992","journal-title":"Eur J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0021","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0960-9822(99)80259-0","article-title":"Threshold of pre-T-cell-receptor surface expression is associated with alphabeta T-cell lineage commitment","volume":"9","author":"Bruno","year":"1999","journal-title":"Curr Biol"},{"key":"2023012312520816500_jlb10563-bib-0022","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1084\/jem.20072425","article-title":"T cell receptor-instructed alphabeta versus gammadelta lineage commitment revealed by single-cell analysis","volume":"205","author":"Kreslavsky","year":"2008","journal-title":"J Exp Med"},{"key":"2023012312520816500_jlb10563-bib-0023","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0167-5699(87)90014-4","article-title":"The T-cell antigen receptor gamma gene: rearrangement and cell lineages","volume":"8","author":"Allison","year":"1987","journal-title":"Immunol Today"},{"key":"2023012312520816500_jlb10563-bib-0024","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/326079a0","article-title":"Differential expression of two distinct T-cell receptors during thymocyte development","volume":"326","author":"Pardoll","year":"1987","journal-title":"Nature"},{"key":"2023012312520816500_jlb10563-bib-0025","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0960-9822(95)00164-3","article-title":"T-cell development. T-cell lineage commitment revisited","volume":"5","author":"Boismenu","year":"1995","journal-title":"Curr Biol"},{"key":"2023012312520816500_jlb10563-bib-0026","doi-asserted-by":"crossref","first-page":"5928","DOI":"10.1073\/pnas.86.15.5928","article-title":"Recognition of a self major histocompatibility complex TL region product by gamma delta T-cell receptors","volume":"86","author":"Bonneville","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023012312520816500_jlb10563-bib-0027","doi-asserted-by":"crossref","first-page":"322836a0","DOI":"10.1038\/322836a0","article-title":"Diversity of murine gamma genes and expression in fetal and adult T lymphocytes","volume":"322","author":"Heilig","year":"1986","journal-title":"Nature"},{"key":"2023012312520816500_jlb10563-bib-0028","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1073\/pnas.87.8.3067","article-title":"T-cell receptor gamma delta and gamma transgenic mice suggest a role of a gamma gene silencer in the generation of alpha beta T cells","volume":"87","author":"Ishida","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023012312520816500_jlb10563-bib-0029","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/342931a0","article-title":"Blockage of alpha beta T-cell development by TCR gamma delta transgenes","volume":"342","author":"Bonneville","year":"1989","journal-title":"Nature"},{"key":"2023012312520816500_jlb10563-bib-0030","doi-asserted-by":"crossref","first-page":"5821","DOI":"10.4049\/jimmunol.154.11.5821","article-title":"Commitment and maintenance of the alpha beta and gamma delta T cell lineages","volume":"154","author":"Sim","year":"1995","journal-title":"J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0031","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/0092-8674(89)90010-X","article-title":"\u03b1\u03b2 lineage-specific expression of the \u03b1 T cell receptor gene by nearby silencers","volume":"59","author":"Winoto","year":"1989","journal-title":"Cell"},{"key":"2023012312520816500_jlb10563-bib-0032","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1002\/eji.1830271130","article-title":"\u03b1\u03b2 Lineage-committed thymocytes can be rescued by the \u03b3\u03b4 T cell receptor (TCR) in the absence of TCR \u03b2 chain","volume":"27","author":"Liv\u00e1k","year":"1997","journal-title":"Eur J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0033","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1084\/jem.193.6.689","article-title":"Evidence that gammadelta versus alphabeta T cell fate determination is initiated independently of T cell receptor signaling","volume":"193","author":"Kang","year":"2001","journal-title":"J Exp Med"},{"key":"2023012312520816500_jlb10563-bib-0034","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1084\/jem.182.6.1921","article-title":"Ontogenic development and tissue distribution of V gamma 1-expressing gamma\/delta T lymphocytes in normal mice","volume":"182","author":"Pereira","year":"1995","journal-title":"J Exp Med"},{"key":"2023012312520816500_jlb10563-bib-0035","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1084\/jem.186.8.1277","article-title":"The common cytokine receptor gamma chain controls survival of gamma\/delta T cells","volume":"186","author":"Malissen","year":"1997","journal-title":"J Exp Med"},{"key":"2023012312520816500_jlb10563-bib-0036","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.4049\/jimmunol.173.4.2516","article-title":"Early expression of a functional TCRbeta chain inhibits TCRgamma gene rearrangements without altering the frequency of TCRgammadelta lineage cells","volume":"173","author":"Gerber","year":"2004","journal-title":"J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0037","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/35020093","article-title":"Different initiation of pre-TCR and \u03b3\u03b4TCR signalling","volume":"406","author":"Saint-Ruf","year":"2000","journal-title":"Nature"},{"key":"2023012312520816500_jlb10563-bib-0038","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S1074-7613(00)80260-5","article-title":"The \u03b1\u03b2 T cell receptor can replace the \u03b3\u03b4 receptor in the development of \u03b3\u03b4 lineage cells","volume":"5","author":"Bruno","year":"1996","journal-title":"Immunity"},{"key":"2023012312520816500_jlb10563-bib-0039","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/343714a0","article-title":"Self-reactive gamma delta T cells are eliminated in the thymus","volume":"343","author":"Dent","year":"1990","journal-title":"Nature"},{"key":"2023012312520816500_jlb10563-bib-0040","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S1074-7613(02)00320-5","article-title":"Distinct structure and signaling potential of the gamma delta TCR complex","volume":"16","author":"Hayes","year":"2002","journal-title":"Immunity"},{"key":"2023012312520816500_jlb10563-bib-0041","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.immuni.2005.03.014","article-title":"TCR signal strength influences alphabeta\/gammadelta lineage fate","volume":"22","author":"Hayes","year":"2005","journal-title":"Immunity"},{"key":"2023012312520816500_jlb10563-bib-0042","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.immuni.2005.04.003","article-title":"Attenuation of gammadeltaTCR signaling efficiently diverts thymocytes to the alphabeta lineage","volume":"22","author":"Haks","year":"2005","journal-title":"Immunity"},{"key":"2023012312520816500_jlb10563-bib-0043","doi-asserted-by":"crossref","first-page":"711","DOI":"10.4049\/jimmunol.178.2.711","article-title":"Two groups of porcine TCR\u03b3\u03b4+ thymocytes behave and diverge differently","volume":"178","author":"\u0160inkora","year":"2007","journal-title":"J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0044","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.it.2011.09.005","article-title":"T cell receptor signalling in \u03b3\u03b4 cell development: strength isn't everything","volume":"32","author":"Turchinovich","year":"2011","journal-title":"Trends Immunol"},{"key":"2023012312520816500_jlb10563-bib-0045","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.it.2017.01.007","article-title":"Thymic determinants of \u03b3\u03b4 T cell differentiation","volume":"38","author":"Mu\u00f1oz-Ruiz","year":"2017","journal-title":"Trends Immunol"},{"key":"2023012312520816500_jlb10563-bib-0046","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.immuni.2008.04.022","article-title":"Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma","volume":"29","author":"Jensen","year":"2008","journal-title":"Immunity"},{"key":"2023012312520816500_jlb10563-bib-0047","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.immuni.2011.04.018","article-title":"Skint-1 identifies a common molecular mechanism for the development of interferon-\u03b3-secreting versus interleukin-17-secreting \u03b3\u03b4 T cells","volume":"35","author":"Turchinovich","year":"2011","journal-title":"Immunity"},{"key":"2023012312520816500_jlb10563-bib-0048","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/ni.2247","article-title":"Intrathymic programming of effector fates in three molecularly distinct \u03b3\u03b4 T cell subtypes","volume":"13","author":"Narayan","year":"2012","journal-title":"Nat Immunol"},{"key":"2023012312520816500_jlb10563-bib-0049","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1111\/imcb.12196","article-title":"How to develop IL-17-producing \u03b3\u03b4 T cells","volume":"96","author":"Fiala","year":"2018","journal-title":"Immunol Cell Biol"},{"key":"2023012312520816500_jlb10563-bib-0050","doi-asserted-by":"crossref","first-page":"796","DOI":"10.3389\/fimmu.2018.00796","article-title":"The emerging complexity of \u03b3\u03b4T17 cells","volume":"9","author":"McKenzie","year":"2018","journal-title":"Front Immunol"},{"key":"2023012312520816500_jlb10563-bib-0051","doi-asserted-by":"crossref","first-page":"ni.3726","DOI":"10.1038\/ni.3726","article-title":"IL-17+ \u03b3\u03b4 T cells as kick-starters of inflammation","volume":"18","author":"Papotto","year":"2017","journal-title":"Nat Immunol"},{"key":"2023012312520816500_jlb10563-bib-0052","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jaut.2017.11.006","article-title":"Innately versatile: \u03b3\u03b417 T cells in inflammatory and autoimmune diseases","volume":"87","author":"Papotto","year":"2017","journal-title":"J Autoimmun"},{"key":"2023012312520816500_jlb10563-bib-0053","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1002\/eji.200939922","article-title":"CCR6 and NK1.1 distinguish between IL-17A and IFN-\u03b3-producing \u03b3\u03b4 effector T cells","volume":"39","author":"Haas","year":"2009","journal-title":"Eur J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0054","doi-asserted-by":"crossref","first-page":"4466","DOI":"10.4049\/jimmunol.178.7.4466","article-title":"Resident V\u03b41+ \u03b3\u03b4 T cells control early infiltration of neutrophils after escherichia coli infection via IL-17 production","volume":"178","author":"Shibata","year":"2007","journal-title":"J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0055","doi-asserted-by":"crossref","first-page":"5940","DOI":"10.4049\/jimmunol.181.9.5940","article-title":"Identification of CD25+ \u03b3\u03b4 T cells as fetal thymus-derived naturally occurring IL-17 producers","volume":"181","author":"Shibata","year":"2008","journal-title":"J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0056","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/343754a0","article-title":"Homing of a \u03b3\u03b4 thymocyte subset with homogeneous T-cell receptors to mucosal epithelia","volume":"343","author":"Itohara","year":"1990","journal-title":"Nature"},{"key":"2023012312520816500_jlb10563-bib-0057","first-page":"1710","article-title":"SCART scavenger receptors identify a novel subset of adult gammadelta T cells","volume":"181","author":"Kisielow","year":"2008","journal-title":"J Exp Med"},{"key":"2023012312520816500_jlb10563-bib-0058","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.immuni.2012.06.003","article-title":"Development of interleukin-17-producing \u03b3\u03b4 T cells is restricted to a functional embryonic wave","volume":"37","author":"Haas","year":"2012","journal-title":"Immunity"},{"key":"2023012312520816500_jlb10563-bib-0059","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.immuni.2013.01.010","article-title":"A network of high-mobility group box transcription factors programs innate interleukin-17 production","volume":"38","author":"Malhotra","year":"2013","journal-title":"Immunity"},{"key":"2023012312520816500_jlb10563-bib-0060","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1084\/jem.20131540","article-title":"The TCR ligand-inducible expression of CD73 marks \u03b3\u03b4 lineage commitment and a metastable intermediate in effector specification","volume":"211","author":"Coffey","year":"2014","journal-title":"J Exp Med"},{"key":"2023012312520816500_jlb10563-bib-0061","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/ni.2773","article-title":"Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness","volume":"15","author":"Wencker","year":"2014","journal-title":"Nat Immunol"},{"key":"2023012312520816500_jlb10563-bib-0062","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1016\/j.celrep.2017.05.071","article-title":"Strong TCR\u03b3\u03b4 signaling prohibits thymic development of IL-17A-Secreting \u03b3\u03b4 T cells","volume":"19","author":"Sumaria","year":"2017","journal-title":"Cell Rep"},{"key":"2023012312520816500_jlb10563-bib-0063","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/ni.3424","article-title":"TCR signal strength controls thymic differentiation of discrete proinflammatory \u03b3\u03b4 T cell subsets","volume":"17","author":"Mu\u00f1oz-Ruiz","year":"2016","journal-title":"Nat Immunol"},{"key":"2023012312520816500_jlb10563-bib-0064","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/ni.1717","article-title":"CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets","volume":"10","author":"Ribot","year":"2009","journal-title":"Nat Immunol"},{"key":"2023012312520816500_jlb10563-bib-0065","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/ni.2702","article-title":"Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory \u03b3\u03b4 T cell subsets","volume":"14","author":"Schmolka","year":"2013","journal-title":"Nat Immunol"},{"key":"2023012312520816500_jlb10563-bib-0066","doi-asserted-by":"crossref","first-page":"6421","DOI":"10.4049\/jimmunol.1002283","article-title":"Cutting edge: adaptive versus innate receptor signals selectively control the pool sizes of murine IFN-\u03b3\u2013 or IL-17\u2013Producing \u03b3\u03b4 T cells upon infection","volume":"185","author":"Ribot","year":"2010","journal-title":"J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0067","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.4049\/jimmunol.168.4.1566","article-title":"T-Bet expression and failure of GATA-3 cross-regulation lead to default production of IFN-\u03b3 by \u03b3\u03b4 T cells","volume":"168","author":"Yin","year":"2002","journal-title":"J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0068","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.immuni.2009.07.010","article-title":"Marked induction of the helix-loop-helix protein Id3 promotes the \u03b3\u03b4 T cell fate and renders their functional maturation notch independent","volume":"31","author":"Lauritsen","year":"2009","journal-title":"Immunity"},{"key":"2023012312520816500_jlb10563-bib-0069","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1038\/s41467-017-02225-5","article-title":"HEB is required for the specification of fetal IL-17-producing \u03b3\u03b4 T cells","volume":"8","author":"In","year":"2017","journal-title":"Nat Commun"},{"key":"2023012312520816500_jlb10563-bib-0070","doi-asserted-by":"crossref","first-page":"12453","DOI":"10.1073\/pnas.0903895106","article-title":"TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity","volume":"106","author":"Kreslavsky","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023012312520816500_jlb10563-bib-0071","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.4049\/jimmunol.0903218","article-title":"Development of promyelocytic zinc finger and ThPOK-expressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3","volume":"184","author":"Alonzo","year":"2010","journal-title":"J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0072","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1038\/emboj.2010.113","article-title":"TCR-mediated ThPOK induction promotes development of mature (CD24\u2212) \u03b3\u03b4 thymocytes","volume":"29","author":"Park","year":"2010","journal-title":"EMBO J"},{"key":"2023012312520816500_jlb10563-bib-0073","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1084\/jem.179.6.1957","article-title":"CD3+CD16+NK1.1+B220+ large granular lymphocytes arise from both alpha-beta TCR+CD4-CD8- and gamma-delta TCR+CD4-CD8- cells","volume":"179","author":"Koyasu","year":"1994","journal-title":"J Exp Med"},{"key":"2023012312520816500_jlb10563-bib-0074","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1084\/jem.182.3.891","article-title":"Developmental arrest of NK1.1+ T cell antigen receptor (TCR)-alpha\/beta+ T cells and expansion of NK1.1+ TCR-gamma\/delta+ T cell development in CD3 zeta-deficient mice","volume":"182","author":"Arase","year":"1995","journal-title":"J Exp Med"},{"key":"2023012312520816500_jlb10563-bib-0075","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1002\/eji.1830260704","article-title":"Mouse \u03b3\u03b4 TCR+NK1.1+ thymocytes specifically produce interleukin-4, are major histocompatibility complex class I independent, and are developmentally related to \u03b1\u03b2 TCR+NK1.1+ thymocytes","volume":"26","author":"Vicari","year":"1996","journal-title":"Eur J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0076","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/0092-8674(89)90135-9","article-title":"Stimulation of a major subset of lymphocytes expressing T cell receptor gamma delta by an antigen derived from Mycobacterium tuberculosis","volume":"57","author":"O'Brien","year":"1989","journal-title":"Cell"},{"key":"2023012312520816500_jlb10563-bib-0077","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/342696a0","article-title":"Limited receptor repertoire in a mycobacteria-reactive subset of gamma delta T lymphocytes","volume":"342","author":"Happ","year":"1989","journal-title":"Nature"},{"key":"2023012312520816500_jlb10563-bib-0078","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.4049\/jimmunol.148.5.1302","article-title":"Gene transfer demonstrates that the V gamma 1.1C gamma 4V delta 6C delta T cell receptor is essential for autoreactivity","volume":"148","author":"Kikuchi","year":"1992","journal-title":"J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0079","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.4049\/jimmunol.163.6.3076","article-title":"IL-4-producing gamma delta T cells that express a very restricted TCR repertoire are preferentially localized in liver and spleen","volume":"163","author":"Gerber","year":"1999","journal-title":"J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0080","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/1521-4141(200101)31:1<205::AID-IMMU205>3.0.CO;2-8","article-title":"Strain-specific TCR repertoire selection of IL-4-producing Thy-1 dull gamma delta thymocytes","volume":"31","author":"Azuara","year":"2001","journal-title":"Eur J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0081","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1002\/eji.201142109","article-title":"Innate NKT\u03b3\u03b4 and NKT\u03b1\u03b2 cells exert similar functions and compete for a thymic niche","volume":"42","author":"Pereira","year":"2012","journal-title":"Eur J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0082","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1084\/jem.20060474","article-title":"Differential synergy of Notch and T cell receptor signaling determines \u03b1\u03b2 versus \u03b3\u03b4 lineage fate","volume":"203","author":"Garbe","year":"2006","journal-title":"J Exp Med"},{"key":"2023012312520816500_jlb10563-bib-0083","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/eji.1830270228","article-title":"A novel subset of adult gamma delta thymocytes that secretes a distinct pattern of cytokines and expresses a very restricted T cell receptor repertoire","volume":"27","author":"Azuara","year":"1997","journal-title":"Eur J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0084","doi-asserted-by":"crossref","first-page":"374","DOI":"10.3389\/fimmu.2012.00374","article-title":"PLZF controls the expression of a limited number of genes essential for NKT cell function","volume":"3","author":"Gleimer","year":"2012","journal-title":"Front Immunol"},{"key":"2023012312520816500_jlb10563-bib-0085","doi-asserted-by":"crossref","first-page":"4280","DOI":"10.4049\/jimmunol.156.11.4280","article-title":"Bias in the gamma delta T cell response to Listeria monocytogenes. V delta 6.3+ cells are a major component of the gamma delta T cell response to Listeria monocytogenes","volume":"156","author":"Belles","year":"1996","journal-title":"J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0086","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.4049\/jimmunol.175.3.1741","article-title":"Delineation of the function of a major gamma delta T cell subset during infection","volume":"175","author":"Andrew","year":"2005","journal-title":"J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0087","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.immuni.2013.06.015","article-title":"\u03b3\u03b4 T cells exhibit multifunctional and protective memory in intestinal tissues","volume":"39","author":"Sheridan","year":"2013","journal-title":"Immunity"},{"key":"2023012312520816500_jlb10563-bib-0088","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1002\/eji.201343759","article-title":"Functional development of \u03b3\u03b4 T cells","volume":"43","author":"Prinz","year":"2013","journal-title":"Eur J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0089","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0167-5699(89)90307-1","article-title":"The thymus selects the useful, neglects the useless and destroys the harmful","volume":"10","author":"von Boehmer","year":"1989","journal-title":"Immunol Today"},{"key":"2023012312520816500_jlb10563-bib-0090","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1046\/j.1440-1711.1998.00709.x","article-title":"Defective TCR expression in transgenic mice constructed using cDNA-based \u03b1- and \u03b2-chain genes under the control of heterologous regulatory elements","volume":"76","author":"Barnden","year":"1998","journal-title":"Immunol Cell Biol"},{"key":"2023012312520816500_jlb10563-bib-0091","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/0092-8674(86)90787-7","article-title":"Diversity, rearrangement, and expression of murine T cell gamma genes","volume":"45","author":"Garman","year":"1986","journal-title":"Cell"},{"key":"2023012312520816500_jlb10563-bib-0092","first-page":"330722a0","article-title":"T-cell receptor \u03b4 gene rearrangements in early thymocytes","volume":"330","author":"Chien","year":"1987","journal-title":"Nature"},{"key":"2023012312520816500_jlb10563-bib-0093","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.4049\/jimmunol.141.11.3753","article-title":"Systematic development of distinct T cell receptor-gamma delta T cell subsets during fetal ontogeny","volume":"141","author":"Houlden","year":"1988","journal-title":"J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0094","doi-asserted-by":"crossref","first-page":"335443a0","DOI":"10.1038\/335443a0","article-title":"Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors","volume":"335","author":"Havran","year":"1988","journal-title":"Nature"},{"key":"2023012312520816500_jlb10563-bib-0095","doi-asserted-by":"crossref","first-page":"7935","DOI":"10.1073\/pnas.87.20.7935","article-title":"Selection of gamma delta T cells with canonical T-cell antigen receptors in fetal thymus","volume":"87","author":"Itohara","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023012312520816500_jlb10563-bib-0096","doi-asserted-by":"crossref","first-page":"4118","DOI":"10.1073\/pnas.79.13.4118","article-title":"Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions","volume":"79","author":"Alt","year":"1982","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023012312520816500_jlb10563-bib-0097","doi-asserted-by":"crossref","first-page":"76","DOI":"10.4049\/jimmunol.137.1.76","article-title":"B lymphocyte-associated antigens on terminal deoxynucleotidyl transferase-positive cells and pre-B cells in bone marrow of the rat","volume":"137","author":"Opstelten","year":"1986","journal-title":"J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0098","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1126\/science.2237433","article-title":"Analysis of junctional diversity during B lymphocyte development","volume":"250","author":"Meek","year":"1990","journal-title":"Science"},{"key":"2023012312520816500_jlb10563-bib-0099","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1084\/jem.172.5.1377","article-title":"Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences","volume":"172","author":"Feeney","year":"1990","journal-title":"J Exp Med"},{"key":"2023012312520816500_jlb10563-bib-0100","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/1074-7613(95)90173-6","article-title":"The role of short homology repeats and TdT in generation of the invariant gamma delta antigen receptor repertoire in the fetal thymus","volume":"3","author":"Zhang","year":"1995","journal-title":"Immunity"},{"key":"2023012312520816500_jlb10563-bib-0101","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/0092-8674(89)90609-0","article-title":"Junctional sequences of T cell receptor gamma delta genes: implications for gamma delta T cell lineages and for a novel intermediate of V-(D)-J joining","volume":"59","author":"Lafaille","year":"1989","journal-title":"Cell"},{"key":"2023012312520816500_jlb10563-bib-0102","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1074-7613(00)80598-1","article-title":"Developmentally programmed rearrangement of T cell receptor V\u03b3 genes is controlled by sequences immediately upstream of the V\u03b3 Genes","volume":"9","author":"Baker","year":"1998","journal-title":"Immunity"},{"key":"2023012312520816500_jlb10563-bib-0103","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1084\/jem.177.3.729","article-title":"Ordered rearrangement of variable region genes of the T cell receptor gamma locus correlates with transcription of the unrearranged genes","volume":"177","author":"Goldman","year":"1993","journal-title":"J Exp Med"},{"key":"2023012312520816500_jlb10563-bib-0104","doi-asserted-by":"crossref","first-page":"4523","DOI":"10.4049\/jimmunol.151.9.4523","article-title":"Evidence that murine V gamma 5 and V gamma 6 gamma delta-TCR+ lymphocytes are derived from a common distinct lineage","volume":"151","author":"Heyborne","year":"1993","journal-title":"J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0105","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1600-065X.1991.tb00592.x","article-title":"Control of \u03b3\u03b4 T-cell development","volume":"120","author":"Raulet","year":"1991","journal-title":"Immunol Rev"},{"key":"2023012312520816500_jlb10563-bib-0106","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/362158a0","article-title":"Selection is not required to produce invariant T-cell receptor gamma-gene junctional sequences","volume":"362","author":"Asarnow","year":"1993","journal-title":"Nature"},{"key":"2023012312520816500_jlb10563-bib-0107","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S1074-7613(02)00285-6","article-title":"Redundant and unique roles of two enhancer elements in the TCRgamma locus in gene regulation and gammadelta T cell development","volume":"16","author":"Xiong","year":"2002","journal-title":"Immunity"},{"key":"2023012312520816500_jlb10563-bib-0108","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1073\/pnas.0303738101","article-title":"The genomic arrangement of T cell receptor variable genes is a determinant of the developmental rearrangement pattern","volume":"101","author":"Xiong","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023012312520816500_jlb10563-bib-0109","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1002\/1521-4141(200007)30:7<1988::AID-IMMU1988>3.0.CO;2-W","article-title":"Developmentally regulated and lineage-specific rearrangement of T cell receptor Valpha\/delta gene segments","volume":"30","author":"Pereira","year":"2000","journal-title":"Eur J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0110","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.4049\/jimmunol.173.5.3261","article-title":"Rates of recombination and chain pair biases greatly influence the primary gamma\u2013delta TCR repertoire in the thymus of adult mice","volume":"173","author":"Pereira","year":"2004","journal-title":"J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0111","doi-asserted-by":"crossref","DOI":"10.5962\/bhl.title.8281","article-title":"The Clonal Selection Theory of Acquired Immunity","author":"Burnet","year":"1959"},{"key":"2023012312520816500_jlb10563-bib-0112","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1126\/science.129.3364.1649","article-title":"Genes and antibodies","volume":"129","author":"Lederberg","year":"1959","journal-title":"Science"},{"key":"2023012312520816500_jlb10563-bib-0113","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/334676a0","article-title":"Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice","volume":"334","author":"Goodnow","year":"1988","journal-title":"Nature"},{"key":"2023012312520816500_jlb10563-bib-0114","doi-asserted-by":"crossref","first-page":"349331a0","DOI":"10.1038\/349331a0","article-title":"Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice","volume":"349","author":"Erikson","year":"1991","journal-title":"Nature"},{"key":"2023012312520816500_jlb10563-bib-0115","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1084\/jem.177.4.1009","article-title":"Receptor editing in self-reactive bone marrow B cells","volume":"177","author":"Tiegs","year":"1993","journal-title":"J Exp Med"},{"key":"2023012312520816500_jlb10563-bib-0116","doi-asserted-by":"crossref","first-page":"jem.20181652","DOI":"10.1084\/jem.20181652","article-title":"Active PI3K abrogates central tolerance in high-avidity autoreactive B cells","volume":"216","author":"Greaves","year":"2019","journal-title":"J Exp Med"},{"key":"2023012312520816500_jlb10563-bib-0117","first-page":"424","article-title":"Deciphering thymic development","volume":"5","author":"Boehmer","year":"2014","journal-title":"Front Immunol"},{"key":"2023012312520816500_jlb10563-bib-0118","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0092-8674(90)90019-B","article-title":"Recognition of the product of a novel MHC TL region gene (27b) by a mouse \u03b3\u03b4 T cell receptor","volume":"62","author":"Ito","year":"1990","journal-title":"Cell"},{"key":"2023012312520816500_jlb10563-bib-0119","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1084\/jem.168.5.1899","article-title":"Structure and specificity of T cell receptor gamma\/delta on major histocompatibility complex antigen-specific CD3+, CD4-, CD8- T lymphocytes","volume":"168","author":"Bluestone","year":"1988","journal-title":"J Exp Med"},{"key":"2023012312520816500_jlb10563-bib-0120","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1101\/SQB.1989.054.01.006","article-title":"A TCR gamma delta cell recognizing a novel TL-encoded gene product","volume":"54 Pt 1","author":"Houlden","year":"1989","journal-title":"Cold Spring Harb Sym"},{"key":"2023012312520816500_jlb10563-bib-0121","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/330262a0","article-title":"Major histocompatibility complex-linked specificity of gamma delta receptor-bearing T lymphocytes","volume":"330","author":"Matis","year":"1987","journal-title":"Nature"},{"key":"2023012312520816500_jlb10563-bib-0122","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1126\/science.1106480","article-title":"Antigen recognition determinants of gammadelta T cell receptors","volume":"308","author":"Shin","year":"2005","journal-title":"Science"},{"key":"2023012312520816500_jlb10563-bib-0123","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1126\/science.1106885","article-title":"Structure of a gd T cell receptor in complex with the nonclassical MHC T22","volume":"308","author":"Adams","year":"2005","journal-title":"Science"},{"key":"2023012312520816500_jlb10563-bib-0124","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/ni.1620","article-title":"An autonomous CDR3delta is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by gammadelta T cells","volume":"9","author":"Adams","year":"2008","journal-title":"Nat Immunol"},{"key":"2023012312520816500_jlb10563-bib-0125","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1002\/eji.1830231016","article-title":"Evidence for programmed cell death of self-reactive gamma delta T cell receptor-positive thymocytes","volume":"23","author":"Dent","year":"1993","journal-title":"Eur J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0126","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/344163a0","article-title":"Self-tolerance to transgenic gamma delta T cells by intrathymic inactivation","volume":"344","author":"Bonneville","year":"1990","journal-title":"Nature"},{"key":"2023012312520816500_jlb10563-bib-0127","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1084\/jem.174.1.293","article-title":"A gamma\/delta cell receptor heterodimer induces the expression of CD4 and CD8 in thymocytes","volume":"174","author":"Iwashima","year":"1991","journal-title":"J Exp Med"},{"key":"2023012312520816500_jlb10563-bib-0128","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1172\/JCI7437","article-title":"Autospecific gammadelta thymocytes that escape negative selection find sanctuary in the intestine","volume":"104","author":"Lin","year":"1999","journal-title":"J Clin Invest"},{"key":"2023012312520816500_jlb10563-bib-0129","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1084\/jem.175.1.65","article-title":"Mechanism of self-tolerance of gamma\/delta T cells in epithelial tissue","volume":"175","author":"Barrett","year":"1992","journal-title":"J Exp Med"},{"key":"2023012312520816500_jlb10563-bib-0130","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1126\/science.1831565","article-title":"Requirement for positive selection of gamma delta receptor-bearing T cells","volume":"253","author":"Wells","year":"1991","journal-title":"Science"},{"key":"2023012312520816500_jlb10563-bib-0131","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/j.1460-2075.1992.tb05023.x","article-title":"Blockade of transgenic gamma delta T cell development in beta 2-microglobulin deficient mice","volume":"11","author":"Pereira","year":"1992","journal-title":"EMBO J"},{"key":"2023012312520816500_jlb10563-bib-0132","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1073\/pnas.1718328115","article-title":"Role of a selecting ligand in shaping the murine \u03b3\u03b4-TCR repertoire","volume":"115","author":"Fahl","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023012312520816500_jlb10563-bib-0133","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/ni1371","article-title":"Visualization of the earliest steps of gammadelta T cell development in the adult thymus","volume":"7","author":"Prinz","year":"2006","journal-title":"Nat Immunol"},{"key":"2023012312520816500_jlb10563-bib-0134","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.immuni.2012.06.003","article-title":"Development of interleukin-17-producing \u03b3\u03b4 T cells is restricted to a functional embryonic wave","volume":"37","author":"Haas","year":"2012","journal-title":"Immunity"},{"key":"2023012312520816500_jlb10563-bib-0135","doi-asserted-by":"crossref","first-page":"4960","DOI":"10.1182\/blood-2009-04-218156","article-title":"Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells","volume":"114","author":"D\u00fcber","year":"2009","journal-title":"Blood"},{"key":"2023012312520816500_jlb10563-bib-0136","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.immuni.2009.08.004","article-title":"\u03b3\u03b4 T cell receptors without a job","volume":"31","author":"Kapsenberg","year":"2009","journal-title":"Immunity"},{"key":"2023012312520816500_jlb10563-bib-0137","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1002\/eji.201040727","article-title":"Constant TCR triggering suggests that the TCR expressed on intestinal intraepithelial \u03b3\u03b4 T cells is functional in vivo","volume":"40","author":"Malinarich","year":"2010","journal-title":"Eur J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0138","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.cell.2016.08.030","article-title":"Epithelia use butyrophilin-like molecules to shape organ-specific \u03b3\u03b4 T cell compartments","volume":"167","author":"Barros","year":"2016","journal-title":"Cell"},{"key":"2023012312520816500_jlb10563-bib-0139","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1084\/jem.20181439","article-title":"Genetic models reveal origin, persistence and non-redundant functions of IL-17-producing \u03b3\u03b4 T cells","volume":"215","author":"Sandrock","year":"2018","journal-title":"J Exp Med"},{"key":"2023012312520816500_jlb10563-bib-0140","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.15252\/embr.201744200","article-title":"IL-23 drives differentiation of peripheral \u03b3\u03b417 T cells from adult bone marrow-derived precursors","volume":"18","author":"Papotto","year":"2017","journal-title":"EMBO Rep"},{"key":"2023012312520816500_jlb10563-bib-0141","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.4049\/jimmunol.1700287","article-title":"IL-1\u03b2 and IL-23 promote extrathymic commitment of CD27+CD122\u2212 \u03b3\u03b4 T cells to \u03b3\u03b4T17 cells","volume":"199","author":"Muschaweckh","year":"2017","journal-title":"J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0142","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.4049\/jimmunol.172.6.3573","article-title":"A keratinocyte-responsive \u03b3\u03b4 TCR is necessary for dendritic epidermal T cell activation by damaged keratinocytes and maintenance in the epidermis","volume":"172","author":"Jameson","year":"2004","journal-title":"J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0143","doi-asserted-by":"crossref","first-page":"4282","DOI":"10.4049\/jimmunol.1501220","article-title":"Differential requirements of TCR signaling in homeostatic maintenance and function of dendritic epidermal T cells","volume":"195","author":"Zhang","year":"2015","journal-title":"J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0144","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nri.2017.101","article-title":"\u03b3\u03b4 T cells in homeostasis and host defence of epithelial barrier tissues","volume":"17","author":"Witherden","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"2023012312520816500_jlb10563-bib-0145","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.3389\/fimmu.2018.02636","article-title":"Tissue adaptations of memory and tissue-resident gamma delta T cells","volume":"9","author":"Khairallah","year":"2018","journal-title":"Front Immunol"},{"key":"2023012312520816500_jlb10563-bib-0146","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.4049\/jimmunol.142.6.2112","article-title":"T cell receptor-gamma and -delta genes preferentially utilized by adult thymocytes for the surface expression","volume":"142","author":"Takagaki","year":"1989","journal-title":"J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0147","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1073\/pnas.86.2.631","article-title":"Different gamma delta T-cell receptors are expressed on thymocytes at different stages of development","volume":"86","author":"Ito","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023012312520816500_jlb10563-bib-0148","doi-asserted-by":"crossref","first-page":"7348","DOI":"10.4049\/jimmunol.0900465","article-title":"Cutting edge: \u03b3\u03b4 intraepithelial lymphocytes of the small intestine are not biased toward thymic antigens","volume":"182","author":"Jensen","year":"2009","journal-title":"J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0149","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1182\/blood.V98.9.2626","article-title":"Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor \u03b3\u03b4+ gut intraepithelial lymphocytes","volume":"98","author":"Wurbel","year":"2001","journal-title":"Blood"},{"key":"2023012312520816500_jlb10563-bib-0150","doi-asserted-by":"crossref","first-page":"134","DOI":"10.4049\/jimmunol.168.1.134","article-title":"Characterization of CCR9 expression and CCL25\/thymus-expressed chemokine responsiveness during T cell development: CD3highCD69+ thymocytes and \u03b3\u03b4TCR+ thymocytes preferentially respond to CCL25","volume":"168","author":"Uehara","year":"2002","journal-title":"J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0151","doi-asserted-by":"crossref","first-page":"5160","DOI":"10.4049\/jimmunol.1001652","article-title":"Intra- and intercompartmental movement of \u03b3\u03b4 T cells: intestinal intraepithelial and peripheral \u03b3\u03b4 T cells represent exclusive nonoverlapping populations with distinct migration characteristics","volume":"185","author":"Chennupati","year":"2010","journal-title":"J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0152","doi-asserted-by":"crossref","first-page":"13386","DOI":"10.1096\/fj.201901356R","article-title":"Axl is a key regulator of intestinal \u03b3\u03b4 T-cell homeostasis","volume":"33","author":"Kim","year":"2019","journal-title":"FASEB J"},{"key":"2023012312520816500_jlb10563-bib-0153","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1083\/jcb.89.3.485","article-title":"Antibodies to the major insoluble milk fat globule membrane-associated protein: specific location in apical regions of lactating epithelial cells","volume":"89","author":"Franke","year":"1981","journal-title":"J Cell Biol"},{"key":"2023012312520816500_jlb10563-bib-0154","first-page":"1","article-title":"Regulation of immunity by butyrophilins","volume":"34","author":"Rhodes","year":"2015","journal-title":"Annu Rev Immunol"},{"key":"2023012312520816500_jlb10563-bib-0155","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.it.2011.09.007","article-title":"Butyrophilins: an emerging family of immune regulators","volume":"33","author":"Abeler-D\u00f6rner","year":"2012","journal-title":"Trends Immunol"},{"key":"2023012312520816500_jlb10563-bib-0156","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/ng.108","article-title":"Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal \u03b3\u03b4 T cells","volume":"40","author":"Boyden","year":"2008","journal-title":"Nat Genet"},{"key":"2023012312520816500_jlb10563-bib-0157","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1073\/pnas.1010890108","article-title":"Skint-1 is a highly specific, unique selecting component for epidermal T cells","volume":"108","author":"Barbee","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023012312520816500_jlb10563-bib-0158","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1073\/pnas.88.1.43","article-title":"Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor gamma delta","volume":"88","author":"Bandeira","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023012312520816500_jlb10563-bib-0159","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0092-8674(90)90166-C","article-title":"Extrathymic selection of TCR gamma delta + T cells by class II major histocompatibility complex molecules","volume":"63","author":"Lefrancois","year":"1990","journal-title":"Cell"},{"key":"2023012312520816500_jlb10563-bib-0160","doi-asserted-by":"crossref","first-page":"4376","DOI":"10.1073\/pnas.1010647108","article-title":"Butyrophilin-like 1 encodes an enterocyte protein that selectively regulates functional interactions with T lymphocytes","volume":"108","author":"Bas","year":"2011","journal-title":"Proc National Acad Sci USA"},{"key":"2023012312520816500_jlb10563-bib-0161","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/ni.3705","article-title":"\u03b3\u03b4 T cells get adaptive","volume":"18","author":"Silva-Santos","year":"2017","journal-title":"Nat Immunol"},{"key":"2023012312520816500_jlb10563-bib-0162","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1038\/s41590-018-0253-5","article-title":"The \u03b3\u03b4TCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness","volume":"19","author":"Melandri","year":"2018","journal-title":"Nat Immunol"},{"key":"2023012312520816500_jlb10563-bib-0163","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2019.09.006","article-title":"Butyrophilin-like 3 directly binds a human V\u03b34+ T cell receptor using a modality distinct from clonally-restricted antigen","author":"Willcox","year":"2019","journal-title":"Immunity"},{"key":"2023012312520816500_jlb10563-bib-0164","doi-asserted-by":"crossref","first-page":"311","DOI":"10.4049\/jimmunol.1800934","article-title":"\u03b3\u03b4 T cell update: adaptate orchestrators of immune surveillance","volume":"203","author":"Hayday","year":"2019","journal-title":"J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0165","doi-asserted-by":"crossref","first-page":"e1004481","DOI":"10.1371\/journal.ppat.1004481","article-title":"Control of murine cytomegalovirus infection by \u03b3\u03b4 T cells","volume":"11","author":"Sell","year":"2015","journal-title":"PLoS Pathog"},{"key":"2023012312520816500_jlb10563-bib-0166","doi-asserted-by":"crossref","first-page":"e1004702","DOI":"10.1371\/journal.ppat.1004702","article-title":"\u03b3\u03b4 T cells confer protection against murine cytomegalovirus (MCMV)","volume":"11","author":"Khairallah","year":"2015","journal-title":"PLoS Pathog"},{"key":"2023012312520816500_jlb10563-bib-0167","doi-asserted-by":"crossref","first-page":"14760","DOI":"10.1038\/ncomms14760","article-title":"Clonal selection in the human V\u03b41 T cell repertoire indicates \u03b3\u03b4 TCR-dependent adaptive immune surveillance","volume":"8","author":"Davey","year":"2017","journal-title":"Nat Commun"},{"key":"2023012312520816500_jlb10563-bib-0168","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/ni.3686","article-title":"Human \u03b3\u03b4 T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection","volume":"18","author":"Ravens","year":"2017","journal-title":"Nat Immunol"},{"key":"2023012312520816500_jlb10563-bib-0169","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.immuni.2018.01.009","article-title":"A macrophage colony-stimulating-factor-producing \u03b3\u03b4 T cell subset prevents malarial parasitemic recurrence","volume":"48","author":"Mamedov","year":"2018","journal-title":"Immunity"},{"key":"2023012312520816500_jlb10563-bib-0170","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.cell.2015.08.004","article-title":"Robust anti-viral immunity requires multiple distinct T cell-dendritic cell interactions","volume":"162","author":"Eickhoff","year":"2015","journal-title":"Cell"},{"key":"2023012312520816500_jlb10563-bib-0171","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00251-014-0763-8","article-title":"V\u03b39 and V\u03b42 T cell antigen receptor genes and butyrophilin 3 (BTN3) emerged with placental mammals and are concomitantly preserved in selected species like alpaca (Vicugna pacos)","volume":"66","author":"Karunakaran","year":"2014","journal-title":"Immunogenetics"},{"key":"2023012312520816500_jlb10563-bib-0172","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3389\/fimmu.2018.00265","article-title":"The armadillo (dasypus novemcinctus): a witness but not a functional example for the emergence of the butyrophilin 3\/V\u03b39V\u03b42 system in placental mammals","volume":"9","author":"Fichtner","year":"2018","journal-title":"Front Immunol"},{"key":"2023012312520816500_jlb10563-bib-0173","doi-asserted-by":"crossref","first-page":"e0123258","DOI":"10.1371\/journal.pone.0123258","article-title":"The SKINT1-Like gene is inactivated in hominoids but not in all primate species: implications for the origin of dendritic epidermal T cells","volume":"10","author":"Mohamed","year":"2015","journal-title":"PLoS One"},{"key":"2023012312520816500_jlb10563-bib-0174","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.4049\/jimmunol.1100804","article-title":"Identification of a novel proinflammatory human skin-homing V\u03b39V\u03b42 T cell subset with a potential role in psoriasis","volume":"187","author":"Laggner","year":"2011","journal-title":"J Immunol"},{"key":"2023012312520816500_jlb10563-bib-0175","doi-asserted-by":"crossref","first-page":"4031","DOI":"10.1172\/JCI93396","article-title":"Clinically resolved psoriatic lesions contain psoriasis-specific IL-17\u2013producing \u03b1\u03b2 T cell clones","volume":"127","author":"Matos","year":"2017","journal-title":"J Clin Invest"},{"key":"2023012312520816500_jlb10563-bib-0176","doi-asserted-by":"crossref","first-page":"e120682","DOI":"10.1172\/jci.insight.120682","article-title":"Meta-analysis of RNA sequencing datasets reveals an association between TRAJ23, psoriasis, and IL-17A","volume":"3","author":"Merleev","year":"2018","journal-title":"JCI Insight"},{"key":"2023012312520816500_jlb10563-bib-0177","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/imm.13032","article-title":"Developmental origins of murine \u03b3\u03b4 T-cell subsets","volume":"156","author":"Sumaria","year":"2019","journal-title":"Immunology"},{"key":"2023012312520816500_jlb10563-bib-0178","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1084\/jem.20050359","article-title":"The timing of TCR\u03b1 expression critically influences T cell development and selection","volume":"202","author":"Baldwin","year":"2005","journal-title":"J Exp Medicine"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2FJLB.1MR0120-237R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JLB.1MR0120-237R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/JLB.1MR0120-237R","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/107\/6\/993\/48795977\/jlb10563.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/107\/6\/993\/48795977\/jlb10563.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T13:11:04Z","timestamp":1677503464000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/107\/6\/993\/6884299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,18]]},"references-count":178,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,2,18]]},"published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.1mr0120-237r","relation":{},"ISSN":["1938-3673","0741-5400"],"issn-type":[{"type":"electronic","value":"1938-3673"},{"type":"print","value":"0741-5400"}],"subject":[],"published-other":{"date-parts":[[2020,6]]},"published":{"date-parts":[[2020,2,18]]},"assertion":[{"value":"2019-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}