{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:19:50Z","timestamp":1787933990599,"version":"build-2784847793"},"reference-count":163,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T00:00:00Z","timestamp":1581033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T00:00:00Z","timestamp":1581033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T00:00:00Z","timestamp":1581033600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Ka 502\/19-1"],"award-info":[{"award-number":["Ka 502\/19-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Ka 502\/19\u20101"],"award-info":[{"award-number":["Ka 502\/19\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Vitamin C (VitC) is an essential vitamin that needs to be provided through exogenous sources. It is a potent anti-oxidant, and an essential cofactor for many enzymes including a group of enzymes that modulate epigenetic regulation of gene expression. Moreover, VitC has a significant influence on T-cell differentiation, and can directly interfere with T-cell signaling. Conventional CD4 and CD8 T cells express the \u03b1\u03b2 TCR and recognize peptide antigens in the context of MHC presentation. The numerically small population of \u03b3\u03b4 T cells recognizes antigens in an MHC-independent manner. \u03b3\u03b4 T cells kill a broad variety of malignant cells, and because of their unique features, are interesting candidates for cancer immunotherapy. In this review, we summarize what is known about the influence of VitC on T-cell activation and differentiation with a special focus on \u03b3\u03b4 T cells. The known mechanisms of action of VitC on \u03b1\u03b2 T cells are discussed and extrapolated to the effects observed on \u03b3\u03b4 T-cell activation and differentiation. Overall, VitC enhances proliferation and effector functions of \u03b3\u03b4 T cells and thus may help to increase the efficacy of \u03b3\u03b4 T cells applied as cancer immunotherapy in adoptive cell transfer.<\/jats:p>","DOI":"10.1002\/jlb.1mr1219-245r","type":"journal-article","created":{"date-parts":[[2020,2,8]],"date-time":"2020-02-08T07:35:57Z","timestamp":1581147357000},"page":"1009-1022","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A comparative view on vitamin C effects on \u03b1\u03b2- versus \u03b3\u03b4 T-cell activation and differentiation"],"prefix":"10.1093","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7669-3806","authenticated-orcid":false,"given":"Christian","family":"Peters","sequence":"first","affiliation":[{"name":"Institute of Immunology, Christian-Albrechts-University Kiel , Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0410-0933","authenticated-orcid":false,"given":"L\u00e9once","family":"Kouakanou","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Christian-Albrechts-University Kiel , Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4160-7103","authenticated-orcid":false,"given":"Dieter","family":"Kabelitz","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Christian-Albrechts-University Kiel , Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,2,7]]},"reference":[{"key":"2023012312520799300_jlb10552-bib-0001","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/odi.12446","article-title":"Vitamin C: the known and the unknown and Goldilocks","volume":"22","author":"Padayatty","year":"2016","journal-title":"Oral Dis"},{"key":"2023012312520799300_jlb10552-bib-0002","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/S0304-4165(99)00123-3","article-title":"Random nucleotide substitutions in primate nonfunctional gene for L-gulono-gamma-lactone oxidase, the missing enzyme in L-ascorbic acid biosynthesis","volume":"1472","author":"Ohta","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"2023012312520799300_jlb10552-bib-0003","first-page":"8936156","article-title":"Vitamin C in stem cell biology: impact on extracellular matrix homeostasis and epigenetics","author":"D'Aniello","year":"2017","journal-title":"Stem Cells Int"},{"key":"2023012312520799300_jlb10552-bib-0004","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/364079a0","article-title":"Mammalian facilitative hexose transporters mediate the transport of dehydroascorbic acid","volume":"364","author":"Vera","year":"1993","journal-title":"Nature"},{"key":"2023012312520799300_jlb10552-bib-0005","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00726-007-0555-7","article-title":"SVCT1 and SVCT2: key proteins for vitamin C uptake","volume":"34","author":"Savini","year":"2008","journal-title":"Amino Acids"},{"key":"2023012312520799300_jlb10552-bib-0006","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1079\/BJN19820059","article-title":"The distribution of ascorbic acid between various cellular components of blood, in normal individuals, and its relation to the plasma concentration","volume":"47","author":"Evans","year":"1982","journal-title":"Br J Nutr"},{"key":"2023012312520799300_jlb10552-bib-0007","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1073\/pnas.73.10.3685","article-title":"Supplemental ascorbate in the supportive treatment of cancer: prolongation of survival times in terminal human cancer","volume":"73","author":"Cameron","year":"1976","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023012312520799300_jlb10552-bib-0008","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1056\/NEJM198501173120301","article-title":"High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. 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