{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:06:31Z","timestamp":1790240791488,"version":"4.1.0"},"reference-count":97,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"publisher","award":["K22 AI 116802"],"award-info":[{"award-number":["K22 AI 116802"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K22 AI 116802"],"award-info":[{"award-number":["K22 AI 116802"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,11,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>NK cells are important mediators of immunological defense against pathogens and cancer, owing in part to their ability to directly kill infected and malignant host cells. Although historically considered cells of the innate immune system, a growing body of literature indicates that NK cells have the capacity to mount immune responses with features of immunological memory, including enhanced recall responses that are long-lived and Ag-specific. Anamnestic NK cell responses in mice have now been described in a broad range of immunological settings, including viral and bacterial infections, hapten-induced contact hypersensitivity (CHS) reactions, and alloantigen responses. Memory-like NK cell populations have also been identified in humans, most notably in the context of human cytomegalovirus (HCMV) infection. Here, an overview of these studies is provided with discussion of the molecular, transcriptional, and epigenetic pathways that regulate adaptive NK cell responses.<\/jats:p>\n               <jats:p>Review on notable examples of memory immune responses by NK cells in humans and mice, and description of the molecular pathways that regulate such responses.<\/jats:p>","DOI":"10.1002\/jlb.1ri0917-366r","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T08:59:12Z","timestamp":1535619552000},"page":"1087-1096","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Memory responses by natural killer cells"],"prefix":"10.1093","volume":"104","author":[{"given":"Aimee M","family":"Beaulieu","sequence":"first","affiliation":[{"name":"Center for Immunity and Inflammation, Rutgers\u2014The State University of New Jersey , Newark, New Jersey, USA"},{"name":"Department of Microbiology, Biochemistry, and Molecular Genetics, Rutgers\u2014The State University of New Jersey , Newark, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,8,29]]},"reference":[{"key":"2023032406071119400_jlb10232-cit-0001","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nrc.2015.5","article-title":"NK cells and cancer: you can teach innate cells new tricks","volume":"16","author":"Morvan","year":"2016","journal-title":"Nat Rev Cancer"},{"key":"2023032406071119400_jlb10232-cit-0002","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1146\/annurev-immunol-032712-100001","article-title":"Control of human viral infections by natural killer cells","volume":"31","author":"Jost","year":"2013","journal-title":"Annu Rev Immunol"},{"key":"2023032406071119400_jlb10232-cit-0003","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/nri3044","article-title":"NK cell development, homeostasis and function: parallels 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