{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:29:56Z","timestamp":1792808996031,"version":"4.5.0"},"reference-count":455,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":180,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10,26]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Since their discovery in the 1970s, purinergic receptors have been shown to play key roles in a wide variety of biologic systems and cell types. In the immune system, purinergic receptors participate in innate immunity and in the modulation of the adaptive immune response. In particular, P2 receptors, which respond to extracellular nucleotides, are widely expressed on leukocytes, causing the release of cytokines and chemokines and the formation of inflammatory mediators, and inducing phagocytosis, degranulation, and cell death. The activity of these receptors is regulated by ectonucleotidases\u2014expressed in these same cell types\u2014which regulate the availability of nucleotides in the extracellular environment. In this article, we review the characteristics of the main purinergic receptor subtypes present in the immune system, focusing on the P2 family. In addition, we describe the physiologic roles of the P2 receptors already identified in leukocytes and how they can positively or negatively modulate the development of infectious diseases, inflammation, and pain.<\/jats:p>","DOI":"10.1002\/jlb.2ru0421-226rr","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T09:04:03Z","timestamp":1657875843000},"page":"983-1012","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Physiologic roles of P2 receptors in leukocytes"],"prefix":"10.1093","volume":"112","author":[{"given":"Anael Viana Pinto","family":"Alberto","sequence":"first","affiliation":[{"name":"Laboratory of Cellular Communication, Oswaldo Cruz Institute, Oswaldo Cruz Foundation , Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natiele Carla","family":"da Silva Ferreira","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Communication, Oswaldo Cruz Institute, Oswaldo Cruz Foundation , Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Gustavo Calvano","family":"Bonavita","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Products, Multidisciplinary Center, Federal University of Rio de Janeiro , Maca\u00e9, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar Kenji","family":"Nihei","sequence":"additional","affiliation":[{"name":"Center of Education and Letter, State University of the West of Paran\u00e1 , Foz do Igua\u00e7u, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Pires","family":"de Farias","sequence":"additional","affiliation":[{"name":"Souza Marques School of Medicine, Souza Marques College , Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"da Cunha Bisaggio","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Communication, Oswaldo Cruz Institute, Oswaldo Cruz Foundation , Rio de Janeiro, RJ, Brazil"},{"name":"Federal Institute of Education, Science, and Technology of Rio de Janeiro , Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crist\u00f3v\u00e3o","family":"de Albuquerque","sequence":"additional","affiliation":[{"name":"PositivaMente Consulting , S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson","family":"Savino","sequence":"additional","affiliation":[{"name":"Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation , Rio de Janeiro, RJ, Brazil"},{"name":"Brazilian National Institute of Science and Technology on Neuroimmunomodulation, Rio de Janeiro Research Network on Neuroinflammation , Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robson","family":"Coutinho-Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Immunophysiology, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro , Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Muanis","family":"Persechini","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiophysics, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro , Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Anastacio","family":"Alves","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Communication, Oswaldo Cruz Institute, Oswaldo Cruz Foundation , Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,15]]},"reference":[{"key":"2023032107473906600_","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1042\/EBC20160017","article-title":"The immune system","volume":"60","author":"Nicholson","year":"2016","journal-title":"Essays Biochem"},{"key":"2023032107473906600_","first-page":"143","article-title":"Nomenclature and classification of purinoceptors","volume":"46","author":"Fredholm","year":"1994","journal-title":"Pharmacol Rev"},{"key":"2023032107473906600_","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11302-006-9038-7","article-title":"Extracellular NAD and ATP: partners in immune cell modulation","volume":"3","author":"Haag","year":"2007","journal-title":"Purinergic Signal"},{"key":"2023032107473906600_","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1124\/pr.110.003129","article-title":"Activation and regulation of purinergic 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cells","volume":"279","author":"Cockcroft","year":"1979","journal-title":"Nature"},{"key":"2023032107473906600_","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1084\/jem.125.2.213","article-title":"The regulation of pinocytosis in mouse macrophages: iI. 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Positively charged amino acids in transmembrane helices 6 and 7 affect agonist potency and specificity","volume":"270","author":"Erb","year":"1995","journal-title":"J Biol Chem"},{"key":"2023032107473906600_","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1124\/mol.52.3.499","article-title":"A mutational analysis of residues essential for ligand recognition at the human P2Y1 receptor","volume":"52","author":"Jiang","year":"1997","journal-title":"Mol Pharmacol"},{"key":"2023032107473906600_","doi-asserted-by":"crossref","first-page":"14639","DOI":"10.1074\/jbc.274.21.14639","article-title":"The role of amino acids in extracellular loops of the human P2Y1 receptor in surface expression and activation processes","volume":"274","author":"Hoffmann","year":"1999","journal-title":"J Biol Chem"},{"key":"2023032107473906600_","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature13288","article-title":"Agonist-bound structure of the human P2Y12 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