{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:36:16Z","timestamp":1790379376327,"version":"4.1.0"},"reference-count":79,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:00:00Z","timestamp":1547510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:00:00Z","timestamp":1547510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:00:00Z","timestamp":1547510400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003141","name":"CONACyT","doi-asserted-by":"publisher","award":["2015-1\/114"],"award-info":[{"award-number":["2015-1\/114"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Laboratorio Nacional de Canalopat\u00edas","award":["279820"],"award-info":[{"award-number":["279820"]}]},{"name":"Laboratorio Nacional de Canalopat\u00edas","award":["DGAPA-UNAM"],"award-info":[{"award-number":["DGAPA-UNAM"]}]},{"name":"Laboratorio Nacional de Canalopat\u00edas","award":["PAPIIT-IN211616"],"award-info":[{"award-number":["PAPIIT-IN211616"]}]},{"name":"Laboratorio Nacional de Canalopat\u00edas","award":["IG200119"],"award-info":[{"award-number":["IG200119"]}]},{"name":"Laboratorio Nacional de Canalopat\u00edas","award":["AH-C"],"award-info":[{"award-number":["AH-C"]}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["2015\u20101\/114"],"award-info":[{"award-number":["2015\u20101\/114"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,4,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Estrogens demonstrate biological activity in numerous organ systems, including the immune system, and exert their effects through estrogen receptors (ER) of two types: intracellular ER\u03b1 and ER\u03b2 that activate transcriptional factors and membrane G protein-coupled ER GPER. The latter is capable to mediate fast activation of cytosolic signaling pathways, influencing transcriptional events in response to estrogens. Tamoxifen (TAM), widely used in chemotherapy of ER\u03b1-positive breast cancer, is considered as an ER\u03b1 antagonist and GPER agonist. TAM was shown to possess \u201coff-target\u201d cytotoxicity, not related to ER in various tumor types. The present work was designed to study biological effects of TAM on the glucocorticoid (GC)-resistant cell line Jurkat, derived from acute lymphoblastic leukemia of T lineage (T-ALL). We have shown that T-ALL cell lines, in contrast to healthy T cells, express only GPER, but not ER\u03b1 or ER\u03b2. TAM compromised mitochondrial function and reduced the viability and proliferation of Jurkat cells. Additionally, TAM induced autophagy in a GPER-dependent manner. Gene expression profiling revealed the up-regulation of autophagy-related gene ATG5. Interestingly, TAM sensitized Jurkat cells to dexamethasone (DEX) treatment, which may be related to its capacity to cause autophagy. We suggest that TAM-based adjuvant therapy may represent a novel strategy in T-ALL patients handling.<\/jats:p>","DOI":"10.1002\/jlb.2vma0818-328r","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T19:23:48Z","timestamp":1547580228000},"page":"983-998","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Tamoxifen induces toxicity, causes autophagy, and partially reverses dexamethasone resistance in Jurkat T cells"],"prefix":"10.1093","volume":"105","author":[{"given":"Liliana","family":"Torres-L\u00f3pez","sequence":"first","affiliation":[{"name":"University Center for Biomedical Research, University of Colima , Colima, Mexico"},{"name":"Faculty for Chemical Sciences, University of Colima , Colima, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Maycotte","sequence":"additional","affiliation":[{"name":"CONACYT-Biomedical Research Center of the East, Mexican Social Security Institute , Puebla, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00f3meda","family":"Li\u00f1\u00e1n-Rico","sequence":"additional","affiliation":[{"name":"CONACYT-University Center for Biomedical Research, University of Colima , Colima, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Li\u00f1\u00e1n-Rico","sequence":"additional","affiliation":[{"name":"University Center for Biomedical Research, University of Colima , Colima, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Donis-Maturano","sequence":"additional","affiliation":[{"name":"Ensenada Biomedical Innovation Department, Center for Scientific Research and Higher Education , Ensenada, Baja California, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n","family":"Delgado-Enciso","sequence":"additional","affiliation":[{"name":"Medical School, Health Services , Colima, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Meza-Robles","sequence":"additional","affiliation":[{"name":"Medical School, Health Services , Colima, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemente","family":"V\u00e1squez-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"University Center for Biomedical Research, University of Colima , Colima, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Hern\u00e1ndez-Cruz","sequence":"additional","affiliation":[{"name":"National Laboratory of Channelopathies (LaNCa), National Autonomous University of Mexico , Mexico City, Mexico"},{"name":"Department of Cognitive Neuroscience-Institute of Cellular Physiology, National Autonomous University of Mexico , Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1526-6517","authenticated-orcid":false,"given":"Oxana","family":"Dobrovinskaya","sequence":"additional","affiliation":[{"name":"University Center for Biomedical Research, University of Colima , Colima, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,1,15]]},"reference":[{"key":"2023032406175651500_jlb10299-cit-0001","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0165-6147(03)00229-3","article-title":"What pharmacologists can learn from recent advances in estrogen signaling?","volume":"24","author":"Gustafsson","year":"2003","journal-title":"Trends Pharmacol Sci"},{"key":"2023032406175651500_jlb10299-cit-0002","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-3-642-02155-8_2","volume-title":"Sex Hormones and Immunity to 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