{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:38:12Z","timestamp":1759333092767},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1985,9,1]],"date-time":"1985-09-01T00:00:00Z","timestamp":494380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1985,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The human monocytic leukemia cell line THP-1 produces an immunosuppressive factor that inhibits interleukin 1 (IL-1)-dependent proliferation of mouse thymocytes as well as the mitogenic effects of concanavalin A (Con A) and phytohemagglutinin (PHA) on human peripheral blood mononuclear cells. The mechanism of action of this factor includes interference with both the production of interleukin 2 (IL-2) and its effects on target cells. Thus, the suppressor abrogates the proliferation of an IL-2-dependent cytotoxic T cell line (CTLL), but not of IL-2 independent cells like the L929 fibroblasts or the EL4 T lymphoma and U937 histiocytic lymphoma lines. It also suppresses IL-2 production by human peripheral blood enriched T cells and mouse splenocytes. The mediator has a molecular weight of 60,000\u201370,000 dalton, as determined by gel filtration chromatography, is heat labile, and is sensitive to trypsin, chymotrypsin, and protease.<\/jats:p>","DOI":"10.1002\/jlb.38.3.429","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T19:42:23Z","timestamp":1515786143000},"page":"429-439","source":"Crossref","is-referenced-by-count":14,"title":["A Macrophage-Derived Factor That Inhibits the Production and Action of Interleukin 2"],"prefix":"10.1093","volume":"38","author":[{"given":"Teresa","family":"Krakauer","sequence":"first","affiliation":[{"name":"Cellular Immunology Section, Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health , Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1985,9,1]]},"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlb.38.3.429","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/38\/3\/429\/49723113\/jlb0429.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/38\/3\/429\/49723113\/jlb0429.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T12:47:37Z","timestamp":1680526057000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/38\/3\/429\/6977998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1985,9,1]]},"published-print":{"date-parts":[[1985,9,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.38.3.429","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1985,9]]},"published":{"date-parts":[[1985,9,1]]}}}