{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T12:13:10Z","timestamp":1770725590378,"version":"3.49.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1986,1,1]],"date-time":"1986-01-01T00:00:00Z","timestamp":504921600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1986,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The defect in phagocytosis and binding of antibody-coated sheep erythrocytes (EA) by peritoneal macrophages of (NZB \u00d7 NZW)F1 or B\/W mice is not intrinsic, but is related to the development of the autoimmune disease process. The defect appears to be confined to peritoneal macrophages, since bone marrow (BM)-derived macrophages have normal to elevated activities in vitro. The peritoneal macrophage defect is not due to blockade of Fc receptors in vivo, as shown by long-term culture or recovery of phagocytic and binding activities after removal of Fc receptors by pronase, but represents a reduced number of receptors with slightly delayed turnover. The defect can be reversed by elicitation of activated macrophages with Corynebacterium parvum, thioglycollate, or proteose peptone in vivo. Normal Fc-mediated phagocytosis and binding by BM-derived macrophages cultured from untreated autoimmune mice is enhanced by pretreatment of mice with C. parvum, thioglycollate, or proteose peptone. The cause of the defect in Fc-mediated phagocytosis by resident peritoneal macrophages of autoimmune mice was not ascertained; it may be due to abnormal macrophage kinetics or to the local effects of lymphokines released as a result of other autoimmune changes.<\/jats:p>","DOI":"10.1002\/jlb.39.1.49","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T17:51:35Z","timestamp":1515001895000},"page":"49-62","source":"Crossref","is-referenced-by-count":4,"title":["Studies of Macrophage Function in Murine Systemic Lupus Erythematosus. 3. The Nature, Anatomical Location, and Reversibility of the Phagocytic Defect"],"prefix":"10.1093","volume":"39","author":[{"given":"Pamela J","family":"Russell","sequence":"first","affiliation":[{"name":"Kolling Institute of Medical Research, Royal North Shore Hospital of Sydney , St. Leonards, N.S.W., Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona H","family":"Cameron","sequence":"additional","affiliation":[{"name":"Kolling Institute of Medical Research, Royal North Shore Hospital of Sydney , St. Leonards, N.S.W., Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1986,1,1]]},"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlb.39.1.49","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/39\/1\/49\/49722915\/jlb0049.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/39\/1\/49\/49722915\/jlb0049.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T12:44:10Z","timestamp":1680525850000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/39\/1\/49\/6978122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1986,1,1]]},"published-print":{"date-parts":[[1986,1,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.39.1.49","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1986,1]]},"published":{"date-parts":[[1986,1,1]]}}}