{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T01:03:42Z","timestamp":1758935022432},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1986,3,1]],"date-time":"1986-03-01T00:00:00Z","timestamp":510019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1986,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Differentiation of human promyelocytic leukemia cells (HL-60) in response to several classes of inducing agents is characterized by the sequential appearance of granulocytic or monocytic markers. Compounds that increase intracellular cAMP in HL-60 cells induce a program of maturation in which cells demonstrate early functional phagocytic properties.<\/jats:p>\n               <jats:p>Cyclic nucleotide metabolism was studied during monocytic and granulocytic differentiation of the HL-60 cell line. In synchronous and nonsynchronous cell cultures, cyclic AMP levels were raised 300-fold or 25-fold in response to N6, O2-dibutyryl adenosine 3\u2032:5\u2032-cyclic monophosphate or the combination of prostaglandin E2 and theophylline, respectively. No reproducible changes in intracellular adenosine 3\u2032:5\u2032-cyclic monophosphate levels occurred in response to retinoic acid or dimethyl sulfoxide, suggesting that changes in adenosine 3\u2032:5\u2032-cyclic monophosphate levels alone do not mediate cell maturation induced by these compounds. Agents that increased intracellular cyclic AMP in HL-60 cells slowed the progress through the S and G2-M phase of the cell cycle, whereas other agents such as dimethyl sulfoxide stimulated cells through this same period.<\/jats:p>","DOI":"10.1002\/jlb.39.3.323","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T17:51:17Z","timestamp":1515001877000},"page":"323-331","source":"Crossref","is-referenced-by-count":12,"title":["Cyclic AMP Levels and Cellular Kinetics During Maturation of Human Promyelocytic Leukemia Cells"],"prefix":"10.1093","volume":"39","author":[{"given":"Thomas J","family":"Chaplinski","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Hematology\/Oncology, East Carolina University School of Medicine , Greenville, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E","family":"Niedel","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Duke University Medical Centre , Durham, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1986,3,1]]},"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlb.39.3.323","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/39\/3\/323\/49722854\/jlb0323.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/39\/3\/323\/49722854\/jlb0323.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T12:42:29Z","timestamp":1680525749000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/39\/3\/323\/6978052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1986,3,1]]},"published-print":{"date-parts":[[1986,3,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.39.3.323","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1986,3]]},"published":{"date-parts":[[1986,3,1]]}}}