{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T02:36:01Z","timestamp":1773801361423,"version":"3.50.1"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:00:00Z","timestamp":1540252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:00:00Z","timestamp":1540252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:00:00Z","timestamp":1540252800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671568"],"award-info":[{"award-number":["81671568"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571608"],"award-info":[{"award-number":["81571608"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771771"],"award-info":[{"award-number":["81771771"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2016A020215106"],"award-info":[{"award-number":["2016A020215106"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030313542"],"award-info":[{"award-number":["2017A030313542"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030313597"],"award-info":[{"award-number":["2017A030313597"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671568"],"award-info":[{"award-number":["81671568"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571608"],"award-info":[{"award-number":["81571608"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771771"],"award-info":[{"award-number":["81771771"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030313542"],"award-info":[{"award-number":["2017A030313542"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030313597"],"award-info":[{"award-number":["2017A030313597"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,12,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Noninfectious liver injury, including the effects of drugs and diet, is a major cause of liver diseases worldwide. The innate inflammatory response to hepatocyte death plays a crucial role in the outcome of liver injury. Mannan-binding lectin (MBL) is a pattern recognition molecule of the innate immune system, which is primarily produced by liver. MBL deficiency occurs with high frequency in the population and is reported associated with predisposition to infectious diseases. We here observed that genetic MBL ablation strongly sensitizes mice to sterile liver injury induced by carbon tetrachloride (CCl4). Aggravated liver damage was shown in CCl4-administrated MBL\u2212\/\u2212 mice, as evidenced by severe hepatocyte death, elevated serum alanine aminotransferase and lactate dehydrogenase activity, and enhanced production of inflammatory cytokines. Mechanistic studies established that MBL deficiency caused increased chemokine CXCL2 production from liver macrophages upon CCl4 stimulation, thereby promoting the hepatic recruitment of neutrophils and subsequent liver damage. Furthermore, MBL-mediated protection from CCl4-induced liver injury was validated by administration of an MBL-expressing liver-specific adeno-associated virus, which effectively ameliorated the hepatic damage in CCl4-treated MBL\u2013\/\u2013 mice. We propose that MBL may be exploited as a new therapeutic approach in the treatment of chemical-induced sterile liver injury in patients with MBL deficiency.<\/jats:p>\n               <jats:p>MBL may be exploited as a new therapeutic approach in the treatment of chemically-induced sterile liver injury in patients with MBL deficiency.<\/jats:p>","DOI":"10.1002\/jlb.3a0718-251r","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:52:51Z","timestamp":1540342371000},"page":"177-186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Mannan-binding lectin deficiency exacerbates sterile liver injury in mice through enhancing hepatic neutrophil recruitment"],"prefix":"10.1093","volume":"105","author":[{"given":"Jia","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Immunology, Southern Medical University , Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junru","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Immunology, Southern Medical University , Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Immunology, Southern Medical University , Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Immunology, Southern Medical University , Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huifang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Immunology, Southern Medical University , Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunzhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Immunology, Southern Medical University , Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Southern Medical University , Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Immunology, Southern Medical University , Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Immunology, Southern Medical University , Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengliang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Immunology, Southern Medical University , Guangzhou, Guangdong, China"},{"name":"Guangdong Province Key Laboratory of Proteomics, Southern Medical University , Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daming","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Immunology, Southern Medical University , Guangzhou, Guangdong, China"},{"name":"Guangdong Province Key Laboratory of Proteomics, Southern Medical University , Guangzhou, Guangdong, China"},{"name":"Institute of Molecular Immunology, Southern Medical University , Guangzhou, Guangdong, China"},{"name":"Microbiome Medicine Center, Southern Medical University , Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,10,23]]},"reference":[{"key":"2023032406270698600_jlb10259-cit-0001","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1053\/j.gastro.2012.09.008","article-title":"Sterile inflammation in the liver","volume":"143","author":"Kubes","year":"2012","journal-title":"Gastroenterology"},{"issue":"Suppl 1","key":"2023032406270698600_jlb10259-cit-0002","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/jgh.12018","article-title":"Sterile inflammation in the liver and pancreas","volume":"28","author":"Hoque","year":"2013","journal-title":"J Gastroenterol Hepatol"},{"key":"2023032406270698600_jlb10259-cit-0003","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1053\/j.gastro.2016.09.048","article-title":"Innate immune cell trafficking and function during sterile inflammation of the liver","volume":"151","author":"McDonald","year":"2016","journal-title":"Gastroenterology"},{"key":"2023032406270698600_jlb10259-cit-0004","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1080\/01926230701584163","article-title":"Role of neutrophils in the pathogenesis of acute inflammatory liver injury","volume":"35","author":"Ramaiah","year":"2007","journal-title":"Toxicol Pathol"},{"key":"2023032406270698600_jlb10259-cit-0005","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.molimm.2004.03.015","article-title":"Mannan-binding lectin\u2013a soluble pattern recognition molecule","volume":"41","author":"Gadjeva","year":"2004","journal-title":"Mol Immunol"},{"issue":"Suppl 7","key":"2023032406270698600_jlb10259-cit-0006","doi-asserted-by":"crossref","first-page":"S440","DOI":"10.1086\/431987","article-title":"The role of the mannose-binding lectin in innate immunity","volume":"41","author":"Takahashi","year":"2005","journal-title":"Clin Infect Dis"},{"key":"2023032406270698600_jlb10259-cit-0007","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1600-065X.2009.00789.x","article-title":"Mannose-binding lectin and innate immunity","volume":"230","author":"Ip","year":"2009","journal-title":"Immunol Rev"},{"key":"2023032406270698600_jlb10259-cit-0008","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1365-2249.2008.03614.x","article-title":"Mannan-binding lectin MBL2 gene polymorphism in chronic hepatitis C: association with the severity of liver fibrosis and response to interferon therapy","volume":"152","author":"Pedroso","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"2023032406270698600_jlb10259-cit-0009","doi-asserted-by":"crossref","first-page":"e75371","DOI":"10.1371\/journal.pone.0075371","article-title":"Association between Mannose-binding lectin gene polymorphisms and hepatitis B virus infection: a meta-analysis","volume":"8","author":"Xu","year":"2013","journal-title":"PLoS One"},{"key":"2023032406270698600_jlb10259-cit-0010","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.clinre.2015.12.015","article-title":"Genetic variants of mannose-binding lectin 2 gene influence progression and prognosis of patients with hepatitis B virus infection in China","volume":"40","author":"Gu","year":"2016","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"2023032406270698600_jlb10259-cit-0011","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/ajt.14408","article-title":"Mannose-binding lectin-deficient donors increase the risk of bacterial infection and bacterial infection-related mortality after liver transplantation","volume":"18","author":"Lombardo-Quezada","year":"2018","journal-title":"Am J Transplant"},{"key":"2023032406270698600_jlb10259-cit-0012","doi-asserted-by":"crossref","first-page":"H1853","DOI":"10.1152\/ajpheart.00049.2009","article-title":"Myocardial ischemia and reperfusion injury is dependent on both IgM and mannose-binding lectin","volume":"297","author":"Busche","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2023032406270698600_jlb10259-cit-0013","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1177\/0023677215571192","article-title":"The carbon tetrachloride model in mice","volume":"49","author":"Scholten","year":"2015","journal-title":"Lab Anim"},{"key":"2023032406270698600_jlb10259-cit-0014","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.jhep.2017.02.026","article-title":"Targeting hepatic macrophages to treat liver diseases","volume":"66","author":"Tacke","year":"2017","journal-title":"J Hepatol"},{"key":"2023032406270698600_jlb10259-cit-0015","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S0168-8278(01)00277-X","article-title":"Contribution of the two Gs-coupled PGE2-receptors EP2-receptor and EP4-receptor to the inhibition by PGE2 of the LPS-induced TNFalpha-formation in Kupffer cells from EP2-or EP4-receptor-deficient mice. Pivotal role for the EP4-receptor in wild type Kupffer cells","volume":"36","author":"Fennekohl","year":"2002","journal-title":"J Hepatol"},{"key":"2023032406270698600_jlb10259-cit-0016","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.jhep.2013.12.025","article-title":"Macrophage heterogeneity in liver injury and fibrosis","volume":"60","author":"Tacke","year":"2014","journal-title":"J Hepatol"},{"key":"2023032406270698600_jlb10259-cit-0017","doi-asserted-by":"crossref","first-page":"5934","DOI":"10.4049\/jimmunol.1201851","article-title":"Role of galectin-3 in classical and alternative macrophage activation in the liver following acetaminophen intoxication","volume":"189","author":"Dragomir","year":"2012","journal-title":"J Immunol"},{"key":"2023032406270698600_jlb10259-cit-0018","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.jhep.2013.12.005","article-title":"A TLR2\/S100A9\/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse","volume":"60","author":"Moles","year":"2014","journal-title":"J Hepatol"},{"key":"2023032406270698600_jlb10259-cit-0019","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3389\/fphys.2012.00213","article-title":"The role of chemokines in acute liver injury","volume":"3","author":"Saiman","year":"2012","journal-title":"Front Physiol"},{"key":"2023032406270698600_jlb10259-cit-0020","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1093\/hmg\/ddi318","article-title":"The \u2018involution\u2019 of mannose-binding lectin","volume":"14","author":"Seyfarth","year":"2005","journal-title":"Hum Mol Genet"},{"key":"2023032406270698600_jlb10259-cit-0021","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1002\/hep.29078","article-title":"Central role of the TIR-domain-containing adaptor-inducing interferon-beta (TRIF) adaptor protein in murine sterile liver injury","volume":"65","author":"Brempelis","year":"2017","journal-title":"Hepatology"},{"key":"2023032406270698600_jlb10259-cit-0022","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/hep.20051","article-title":"Apoptosis: the nexus of liver injury and fibrosis","volume":"39","author":"Canbay","year":"2004","journal-title":"Hepatology"},{"key":"2023032406270698600_jlb10259-cit-0023","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fimmu.2018.00044","article-title":"Clearance of apoptotic cells by tissue epithelia: a putative role for hepatocytes in liver efferocytosis","volume":"9","author":"Davies","year":"2018","journal-title":"Front Immunol"},{"key":"2023032406270698600_jlb10259-cit-0024","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1084\/jem.194.6.781","article-title":"C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells","volume":"194","author":"Ogden","year":"2001","journal-title":"J Exp Med"},{"key":"2023032406270698600_jlb10259-cit-0025","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1189\/jlb.0604342","article-title":"Mannose-binding lectin enhances phagocytosis and killing of Neisseria meningitidis by human macrophages","volume":"77","author":"Jack","year":"2005","journal-title":"J Leukoc Biol"},{"key":"2023032406270698600_jlb10259-cit-0026","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.4049\/jimmunol.166.4.2479","article-title":"A novel role of complement: mice deficient in the fifth component of complement (C5) exhibit impaired liver regeneration","volume":"166","author":"Mastellos","year":"2001","journal-title":"J Immunol"},{"key":"2023032406270698600_jlb10259-cit-0027","doi-asserted-by":"crossref","DOI":"10.1002\/hep.30093","article-title":"High mobility group box-1 drives fibrosis progression signaling via the receptor for advanced glycation end-products in mice","author":"Ge","year":"2018","journal-title":"Hepatology"},{"key":"2023032406270698600_jlb10259-cit-0028","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1379\/1466-1268(2004)009<0058:IOMCIC>2.0.CO;2","article-title":"Induction of molecular chaperones in carbon tetrachloride-treated rat liver: implications in protection against liver damage","volume":"9","author":"Lee","year":"2004","journal-title":"Cell Stress Chaperones"},{"key":"2023032406270698600_jlb10259-cit-0029","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1002\/hep.23148","article-title":"Immature myeloid cells induced by a high-fat diet contribute to liver inflammation","volume":"50","author":"Deng","year":"2009","journal-title":"Hepatology"},{"key":"2023032406270698600_jlb10259-cit-0030","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/hep.22950","article-title":"Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis","volume":"50","author":"Karlmark","year":"2009","journal-title":"Hepatology"},{"key":"2023032406270698600_jlb10259-cit-0031","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1165\/rcmb.2005-0461OC","article-title":"Surfactant proteins A and D enhance pulmonary clearance of Pseudomonas aeruginosa","volume":"34","author":"Giannoni","year":"2006","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2023032406270698600_jlb10259-cit-0032","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.4049\/jimmunol.180.6.4308","article-title":"Neutrophil chemokines KC and macrophage-inflammatory protein-2 are newly synthesized by tissue macrophages using distinct TLR signaling pathways","volume":"180","author":"De Filippo","year":"2008","journal-title":"J Immunol"},{"key":"2023032406270698600_jlb10259-cit-0033","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.3389\/fimmu.2017.01917","article-title":"Intravital microscopic evaluation of the effects of a CXCR2 antagonist in a model of liver ischemia reperfusion injury in mice","volume":"8","author":"de Oliveira","year":"2017","journal-title":"Front Immunol"},{"key":"2023032406270698600_jlb10259-cit-0034","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.3748\/wjg.v23.i17.3043","article-title":"Macrophage inflammatory protein-2 as mediator of inflammation in acute liver injury","volume":"23","author":"Qin","year":"2017","journal-title":"World J Gastroenterol"},{"key":"2023032406270698600_jlb10259-cit-0035","doi-asserted-by":"crossref","first-page":"4717","DOI":"10.4049\/jimmunol.0902444","article-title":"CXC chemokine ligand 2 induced by receptor activator of NF-kappa B ligand enhances osteoclastogenesis","volume":"184","author":"Ha","year":"2010","journal-title":"J Immunol"},{"key":"2023032406270698600_jlb10259-cit-0036","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/cmi.2011.1","article-title":"Mannan-binding lectin directly interacts with Toll-like receptor 4 and suppresses lipopolysaccharide-induced inflammatory cytokine secretion from THP-1 cells","volume":"8","author":"Wang","year":"2011","journal-title":"Cell Mol Immunol"},{"key":"2023032406270698600_jlb10259-cit-0037","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1128\/IAI.01185-07","article-title":"Evasion of innate immune responses: evidence for mannose binding lectin inhibition of tumor necrosis factor alpha production by macrophages in response to Blastomyces dermatitidis","volume":"76","author":"Koneti","year":"2008","journal-title":"Infect Immun"},{"key":"2023032406270698600_jlb10259-cit-0038","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1189\/jlb.1105683","article-title":"C1q and MBL, components of the innate immune system, influence monocyte cytokine expression","volume":"80","author":"Fraser","year":"2006","journal-title":"J Leukoc Biol"},{"key":"2023032406270698600_jlb10259-cit-0039","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/1348-0421.12245","article-title":"Mannan-binding lectin reduces CpG DNA-induced inflammatory cytokine production by human monocytes","volume":"59","author":"Tang","year":"2015","journal-title":"Microbiol Immunol"},{"key":"2023032406270698600_jlb10259-cit-0040","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.febslet.2014.01.064","article-title":"Mannan binding lectin attenuates double-stranded RNA-mediated TLR3 activation and innate immunity","volume":"588","author":"Liu","year":"2014","journal-title":"FEBS Lett"},{"key":"2023032406270698600_jlb10259-cit-0041","doi-asserted-by":"crossref","first-page":"L280","DOI":"10.1152\/ajplung.00205.2015","article-title":"Effects of mannose-binding lectin on pulmonary gene expression and innate immune inflammatory response to ozone","volume":"311","author":"Ciencewicki","year":"2016","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2023032406270698600_jlb10259-cit-0042","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1172\/JCI96324","article-title":"Hepatic neuregulin 4 signaling defines an endocrine checkpoint for steatosis-to-NASH progression","volume":"127","author":"Guo","year":"2017","journal-title":"J Clin Invest"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2FJLB.3A0718-251R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JLB.3A0718-251R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/JLB.3A0718-251R","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/105\/1\/177\/49557419\/jlb10259.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/105\/1\/177\/49557419\/jlb10259.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T06:38:01Z","timestamp":1679639881000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/105\/1\/177\/6935529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,23]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,10,23]]},"published-print":{"date-parts":[[2018,12,27]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.3a0718-251r","relation":{},"ISSN":["1938-3673","0741-5400"],"issn-type":[{"value":"1938-3673","type":"electronic"},{"value":"0741-5400","type":"print"}],"subject":[],"published-other":{"date-parts":[[2019,1]]},"published":{"date-parts":[[2018,10,23]]}}}