{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T11:33:47Z","timestamp":1774265627026,"version":"3.50.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401649"],"award-info":[{"award-number":["81401649"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Youth Foundation of Science and Technology Department of Jilin Province","award":["20160520050JH"],"award-info":[{"award-number":["20160520050JH"]}]},{"name":"the Science and Technology Project of Education Department of Jilin Province in the Period of 13th Five-year Plan","award":["JJKH20180195KJ"],"award-info":[{"award-number":["JJKH20180195KJ"]}]},{"name":"Youth Science and Technology Development Project of Health and Family Planning Commission of Jilin Province","award":["2017Q017"],"award-info":[{"award-number":["2017Q017"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401649"],"award-info":[{"award-number":["81401649"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Glucocorticoid-induced tumor necrosis factor receptor family-related protein ligand (GITRL), a member of the tumor necrosis factor superfamily, is expressed in APCs and acts as a costimulatory molecule in the immune system. Although the glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR)\/GITRL system has been modulated to promote or decrease T cell-related responses in multiple diseases, studies in macrophages are limited. To address this issue, we compared the expression of GITRL in various types of macrophages and analyzed whether GITRL can affect the fundamental properties and major functions of these cells. Our results demonstrated that M1 polarized macrophages had the highest GITRL levels. Furthermore, GITRL overexpression skewed macrophage polarization toward the M1 phenotype, accelerating proliferation and migration and regulating phagocytosis and killing function. Moreover, GITRL-silenced cells showed a loss of these functions, further confirming its vital role. We also developed an acute peritonitis mouse model, in which macrophages were driven to differentiate into a proinflammatory phenotype with GITRL up-regulation, triggering a positive feedback loop. Our results provide molecular insight into how the GITR\/GITRL system modulates innate immune responses, suggesting that manipulation of the GITR\/GITRL system to treat diseases depends not only on T cell regulation but also on macrophage participation.<\/jats:p>","DOI":"10.1002\/jlb.3a0919-387rr","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T11:15:41Z","timestamp":1576235741000},"page":"309-321","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Biological role of GITR\/GITRL in attributes and immune responses of macrophage"],"prefix":"10.1093","volume":"107","author":[{"given":"Zhuo","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, the Second Hospital of Jilin University , Changchun, Jilin, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, the Second Hospital of Jilin University , Changchun, Jilin, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhua","family":"Li","sequence":"additional","affiliation":[{"name":"School of Public Health, Jilin University , Changchun, Jilin, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the Second Hospital of Jilin University , Changchun, Jilin, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infection Control, the First Hospital of Jilin University , Changchun, Jilin, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangquan","family":"Li","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, the Second Hospital of Jilin University , Changchun, Jilin, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, the Second Hospital of Jilin University , Changchun, Jilin, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9825-4110","authenticated-orcid":false,"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, the Second Hospital of Jilin University , Changchun, Jilin, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,12,13]]},"reference":[{"key":"2023012312511492000_jlb10527-bib-0001","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1002\/eji.200940046","article-title":"Blockade of GITR-GITRL interaction maintains Treg function to prolong allograft survival","volume":"40","author":"Kim","year":"2010","journal-title":"Eur J Immunol"},{"key":"2023012312511492000_jlb10527-bib-0002","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1002\/eji.200425818","article-title":"GITR: a multifaceted regulator of immunity belonging to the tumor necrosis factor receptor superfamily","volume":"35","author":"Nocentini","year":"2010","journal-title":"Eur J Immunol"},{"key":"2023012312511492000_jlb10527-bib-0003","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/eji.200636933","article-title":"GITR\/GITRL: more than an effector T cell co-stimulatory system","volume":"37","author":"Nocentini","year":"2010","journal-title":"Eur J Immunol"},{"key":"2023012312511492000_jlb10527-bib-0004","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/eji.200324804","article-title":"Frontline: gITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations","volume":"34","author":"Ronchetti","year":"2010","journal-title":"Eur J Immunol"},{"key":"2023012312511492000_jlb10527-bib-0005","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.4049\/jimmunol.1103354","article-title":"A novel IL-10-independent regulatory role for B cells in suppressing autoimmunity by maintenance of regulatory T cells via GITR ligand","volume":"188","author":"Ray","year":"2012","journal-title":"J Immunol"},{"key":"2023012312511492000_jlb10527-bib-0006","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1097\/TP.0b013e3181ba6f85","article-title":"GITR blockade facilitates treg mediated allograft survival","volume":"88","author":"Sonawane","year":"2009","journal-title":"Transplantation"},{"key":"2023012312511492000_jlb10527-bib-0007","doi-asserted-by":"crossref","first-page":"e1004675","DOI":"10.1371\/journal.ppat.1004675","article-title":"Enhanced CD8T cell responses through GITR-mediated costimulation resolve chronic viral infection","volume":"11","author":"Pascutti","year":"2015","journal-title":"PLoS Pathog"},{"key":"2023012312511492000_jlb10527-bib-0008","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1084\/jem.20050940","article-title":"Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells","volume":"202","author":"Ko","year":"2005","journal-title":"J Exp Med"},{"key":"2023012312511492000_jlb10527-bib-0009","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nri3405","article-title":"Molecular mechanisms of T cell co-stimulation and co-inhibition","volume":"13","author":"Lieping","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"2023012312511492000_jlb10527-bib-0010","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1080\/14728222.2018.1512588","article-title":"Glucocorticoid-induced TNFR-related gene (GITR) as a therapeutic target for immunotherapy","volume":"22","author":"Riccardi","year":"2018","journal-title":"Expert Opin Ther Targets"},{"key":"2023012312511492000_jlb10527-bib-0011","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1365-2567.2008.03036.x","article-title":"Enhancement of T-cell-mediated anti-tumour immunity via the ectopically expressed glucocorticoid-induced tumour necrosis factor receptor-related receptor ligand (GITRL) on tumours","volume":"127","author":"Piao","year":"2009","journal-title":"Immunology"},{"key":"2023012312511492000_jlb10527-bib-0012","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/cas.12332","article-title":"Suppression of Tregs by anti-GITR antibody enhances the antitumor immunity of IFN-\u03b1 gene therapy for pancreatic cancer","volume":"105","author":"Aida","year":"2013","journal-title":"Cancer Sci"},{"key":"2023012312511492000_jlb10527-bib-0013","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41467-018-08122-9","article-title":"Mature IgD(low\/\u2212) B cells maintain tolerance by promoting regulatory T cell homeostasis","volume":"10","author":"Ray","year":"2019","journal-title":"Nat Commun"},{"key":"2023012312511492000_jlb10527-bib-0014","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/nri1733","article-title":"Monocyte and macrophage heterogeneity","volume":"5","author":"Gordon","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"2023012312511492000_jlb10527-bib-0015","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"2023012312511492000_jlb10527-bib-0016","doi-asserted-by":"crossref","first-page":"15059","DOI":"10.1073\/pnas.2334901100","article-title":"Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells","volume":"100","author":"Masahide","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023012312511492000_jlb10527-bib-0017","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/ni759","article-title":"Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance","volume":"3","author":"Shimizu","year":"2002","journal-title":"Nat Immunol"},{"key":"2023012312511492000_jlb10527-bib-0018","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/j.1365-2249.2007.03363.x","article-title":"Glucocorticoid-induced tumour necrosis factor receptor-related protein-mediated macrophage stimulation may induce cellular adhesion and cytokine expression in rheumatoid arthritis","volume":"148","author":"Bae","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"2023012312511492000_jlb10527-bib-0019","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.molimm.2007.05.013","article-title":"Reverse signaling initiated from GITRL induces NF-kappaB activation through ERK in the inflammatory activation of macrophages","volume":"45","author":"Bae","year":"2008","journal-title":"Mol Immunol"},{"key":"2023012312511492000_jlb10527-bib-0020","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1002\/jnr.22378","article-title":"Stimulation of glucocorticoid-induced tumor necrosis factor receptor family-related protein ligand (GITRL) induces inflammatory activation of microglia in culture","volume":"88","author":"Hwang","year":"2010","journal-title":"J Neurosci Res"},{"key":"2023012312511492000_jlb10527-bib-0021","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1365-2567.2006.02453.x","article-title":"Glucocorticoid-induced tumour necrosis factor receptor family related protein (GITR) mediates inflammatory activation of macrophages that can destabilize atherosclerotic plaques","volume":"119","author":"Kim","year":"2006","journal-title":"Immunology"},{"key":"2023012312511492000_jlb10527-bib-0022","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jim.2012.02.012","article-title":"New and improved methods for measuring lymphocyte proliferation in vitro and in vivo using CFSE-like fluorescent dyes","volume":"379","author":"Quah","year":"2012","journal-title":"J Immunol Methods"},{"key":"2023012312511492000_jlb10527-bib-0023","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","article-title":"Alternative activation of macrophages: mechanism and functions","volume":"32","author":"Gordon","year":"2010","journal-title":"Immunity"},{"key":"2023012312511492000_jlb10527-bib-0024","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.it.2004.09.015","article-title":"The chemokine system in diverse forms of macrophage activation and polarization","volume":"25","author":"Mantovani","year":"2004","journal-title":"Trends Immunol"},{"key":"2023012312511492000_jlb10527-bib-0025","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1471-4906(02)02302-5","article-title":"Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes","volume":"23","author":"Mantovani","year":"2002","journal-title":"Trends Immunol"},{"issue":"10","key":"2023012312511492000_jlb10527-bib-0026","doi-asserted-by":"crossref","first-page":"e002255","DOI":"10.1161\/JAHA.115.002255","article-title":"Myristoylated alanine-rich protein kinase substrate (MARCKS) regulates SmallGTPase Rac1 and Cdc42 activity and Is a critical mediator of vascular smooth muscle cell migration in intimal hyperplasia formation","volume":"4","author":"Yu","year":"2015","journal-title":"J Am Heart Assoc"},{"key":"2023012312511492000_jlb10527-bib-0027","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: in vivo veritas","volume":"122","author":"Sica","year":"2012","journal-title":"J Clin Invest"},{"key":"2023012312511492000_jlb10527-bib-0028","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.4049\/jimmunol.0802597","article-title":"Trimer stabilization, oligomerization, and antibody-mediated cell surface immobilization improve the activity of soluble trimers of CD27L, CD40L, 41BBL, and glucocorticoid-induced TNF receptor ligand","volume":"183","author":"Wyzgol","year":"2009","journal-title":"J Immunol"},{"key":"2023012312511492000_jlb10527-bib-0029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2567.2005.02143.x","article-title":"The intriguing biology of the tumour necrosis factor\/tumour necrosis factor receptor superfamily: players, rules and the games","volume":"115","author":"Hehlgans","year":"2005","journal-title":"Immunology"},{"key":"2023012312511492000_jlb10527-bib-0030","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0014-5793(02)02379-7","article-title":"Recombinant glucocorticoid induced tumor necrosis factor receptor (rGITR) induces NOS in murine macrophage","volume":"514","author":"Shin","year":"2002","journal-title":"FEBS Lett"},{"key":"2023012312511492000_jlb10527-bib-0031","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1096\/fj.13-236505","article-title":"Glucocorticoid-induced TNF receptor family-related protein ligand regulates the migration of monocytes to the inflamed intestine","volume":"28","author":"Liao","year":"2014","journal-title":"FASEB J"},{"key":"2023012312511492000_jlb10527-bib-0032","first-page":"514","article-title":"From monocytes to M1\/M2 macrophages: phenotypical vs. functional differentiation","volume":"5","author":"Paola","year":"2014","journal-title":"Front Immunol"},{"key":"2023012312511492000_jlb10527-bib-0033","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3389\/fimmu.2015.00212","article-title":"Anatomy of a discovery: m1 and m2 macrophages","volume":"6","author":"Mills","year":"2015","journal-title":"Front Immunol"},{"key":"2023012312511492000_jlb10527-bib-0034","doi-asserted-by":"crossref","first-page":"7490","DOI":"10.4049\/jimmunol.0802751","article-title":"GITR triggering induces expansion of both effector and regulatory CD4+ T cells in vivo","volume":"182","author":"van Olffen","year":"2009","journal-title":"J Immunol"},{"key":"2023012312511492000_jlb10527-bib-0035","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.jcyt.2018.05.002","article-title":"Dual effect of glucocorticoid-induced tumor necrosis factor\u2013related receptor ligand carrying mesenchymal stromal cells on small cell lung cancer: a preliminary in vitro study","volume":"20","author":"Kopru","year":"2018","journal-title":"Cytotherapy"},{"key":"2023012312511492000_jlb10527-bib-0036","doi-asserted-by":"crossref","first-page":"575","DOI":"10.4049\/jimmunol.141.2.575","article-title":"Induction of monocyte migration by recombinant macrophage colony-stimulating factor","volume":"141","author":"Wang","year":"1988","journal-title":"J Immunol"},{"key":"2023012312511492000_jlb10527-bib-0037","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1189\/jlb.68.5.593","article-title":"Cellular signaling in macrophage migration and chemotaxis","volume":"68","author":"Jones","year":"2000","journal-title":"J Leukoc Biol"},{"key":"2023012312511492000_jlb10527-bib-0038","doi-asserted-by":"crossref","first-page":"e01376-19","DOI":"10.1128\/mBio.01376-19","article-title":"Chromatin profiling of the repetitive and nonrepetitive genomes of the human fungal pathogen Candida albicans","volume":"10","author":"Price","year":"2019","journal-title":"mBio"},{"key":"2023012312511492000_jlb10527-bib-0039","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s10753-017-0543-3","article-title":"MicroRNA-24 modulates staphylococcus aureus-induced macrophage polarization by suppressing CHI3L1","volume":"40","author":"Jingjing","year":"2017","journal-title":"Inflammation"},{"key":"2023012312511492000_jlb10527-bib-0040","article-title":"The role of polyamines in the regulation of macrophage polarization and function","author":"Latour","year":"2019","journal-title":"Amino Acids"},{"key":"2023012312511492000_jlb10527-bib-0041","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1161\/CIRCRESAHA.110.233775","article-title":"Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPARgamma and LXRalpha pathways","volume":"108","author":"Chinetti-Gbaguidi","year":"2011","journal-title":"Circ Res"},{"key":"2023012312511492000_jlb10527-bib-0042","doi-asserted-by":"crossref","first-page":"4415","DOI":"10.4049\/jimmunol.0713732","article-title":"M2 macrophages phagocytose rituximab-opsonized leukemic targets more efficiently than m1 cells in vitro","volume":"182","author":"Leidi","year":"2009","journal-title":"J Immunol"},{"key":"2023012312511492000_jlb10527-bib-0043","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1146\/annurev-cellbio-111315-125315","article-title":"Cell removal: efferocytosis","volume":"33","author":"Henson","year":"2017","journal-title":"Annu Rev Cell Dev Biol"},{"key":"2023012312511492000_jlb10527-bib-0044","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1093\/rheumatology\/kew324","article-title":"High mobility group box 1 skews macrophage polarization and negatively influences phagocytosis of apoptotic cells","volume":"55","author":"Schaper","year":"2016","journal-title":"Rheumatology (Oxf)"},{"key":"2023012312511492000_jlb10527-bib-0045","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/j.molimm.2010.02.008","article-title":"Scavenger receptor CD163, a Jack-of-all-trades and potential target for cell-directed therapy","volume":"47","author":"Van Gorp","year":"2010","journal-title":"Mol Immunol"},{"key":"2023012312511492000_jlb10527-bib-0046","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1002\/pmic.201300508","article-title":"Proteomic characterization of human proinflammatory M1 and anti-inflammatory M2 macrophages and their response to Candida albicans","volume":"14","author":"Reales-Calderon","year":"2014","journal-title":"Proteomics"},{"key":"2023012312511492000_jlb10527-bib-0047","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.molimm.2017.05.027","article-title":"THP-1 and human peripheral blood mononuclear cell-derived macrophages differ in their capacity to polarize in vitro","volume":"88","author":"Shiratori","year":"2017","journal-title":"Mol Immunol"},{"key":"2023012312511492000_jlb10527-bib-0048","doi-asserted-by":"crossref","first-page":"5803","DOI":"10.1128\/IAI.71.10.5803-5813.2003","article-title":"Molecular characterization of the acute inflammatory response to infections with gram-negative versus gram-positive bacteria","volume":"71","author":"Feezor","year":"2003","journal-title":"Infect Immun"},{"key":"2023012312511492000_jlb10527-bib-0049","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1093\/infdis\/jit177","article-title":"Akt1-mediated regulation of macrophage polarization in a murine model of Staphylococcus aureus pulmonary infection","volume":"208","author":"Xu","year":"2013","journal-title":"J Infect Dis"},{"key":"2023012312511492000_jlb10527-bib-0050","doi-asserted-by":"crossref","first-page":"3581","DOI":"10.1128\/IAI.68.6.3581-3586.2000","article-title":"Gram-positive bacteria are potent inducers of monocytic interleukin-12 (IL-12) while gram-negative bacteria preferentially stimulate IL-10 production","volume":"68","author":"Hessle","year":"2000","journal-title":"Infect Immun"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2FJLB.3A0919-387RR","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JLB.3A0919-387RR","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/JLB.3A0919-387RR","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/107\/2\/309\/48795357\/jlb10527.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/107\/2\/309\/48795357\/jlb10527.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T13:13:15Z","timestamp":1677503595000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/107\/2\/309\/6884284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,13]]},"references-count":50,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,12,13]]},"published-print":{"date-parts":[[2020,2,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.3a0919-387rr","relation":{},"ISSN":["1938-3673","0741-5400"],"issn-type":[{"value":"1938-3673","type":"electronic"},{"value":"0741-5400","type":"print"}],"subject":[],"published-other":{"date-parts":[[2020,2]]},"published":{"date-parts":[[2019,12,13]]},"assertion":[{"value":"2019-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}