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In our previous study, we documented eosinophil infiltration in damaged muscle characteristic of dystrophin-deficient (mdx) mice that model Duchenne muscular dystrophy. Specifically, we found that eosinophils did not promote the generation of muscle lesions, as these persisted in eosinophil-deficient mdx.PHIL mice. To obtain additional insight into these findings, we performed RNA sequencing of eosinophils isolated from muscle tissue of mdx, IL5tg, and mdx.IL5tg mice. We observed profound up-regulation of classical effector proteins (major basic protein-1, eosinophil peroxidase, and eosinophil-associated ribonucleases) in eosinophils isolated from lesion-free muscle from IL5tg mice. By contrast, we observed significant up-regulation of tissue remodeling genes, including proteases, extracellular matrix components, collagen, and skeletal muscle precursors, as well as the immunomodulatory receptor, Trem2, in eosinophils isolated from skeletal muscle tissue from the dystrophin-deficient mdx mice. Although the anti-inflammatory properties of Trem2 have been described in the monocyte\/macrophage lineage, no previous studies have documented its expression in eosinophils. We found that Trem2 was critical for full growth and differentiation of bone marrow-derived eosinophil cultures and full expression of TLR4. Immunoreactive Trem2 was also detected on human peripheral blood eosinophils at levels that correlated with donor body mass index and total leukocyte count. Taken together, our findings provide important insight into the immunomodulatory and remodeling capacity of mouse eosinophils and the flexibility of their gene expression profiles in vivo.<\/jats:p>","DOI":"10.1002\/jlb.3a0920-620r","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T18:58:07Z","timestamp":1610045887000},"page":"679-691","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Differential expression of Triggering Receptor Expressed on Myeloid cells 2 (<i>Trem2<\/i>) in tissue eosinophils"],"prefix":"10.1093","volume":"110","author":[{"given":"Albert C","family":"Sek","sequence":"first","affiliation":[{"name":"Inflammation Immunobiology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland 20892, USA"},{"name":"Research Technologies Development Section, National Institute of 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K","family":"Boddapati","sequence":"additional","affiliation":[{"name":"NIAID Collaborative Bioinformatics Resource, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland 20892, USA"},{"name":"Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research , Frederick, Maryland 21701, USA"},{"name":"Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University , Atlanta, GA 30329, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Ma","sequence":"additional","affiliation":[{"name":"Inflammation Immunobiology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland 20892, USA"},{"name":"Research Technologies Development Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland 20892, USA"},{"name":"Genetic Immunotherapy Section, Laboratory of Clinical Microbiology and Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland 20892, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy E","family":"Geslewitz","sequence":"additional","affiliation":[{"name":"Inflammation Immunobiology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland 20892, USA"},{"name":"Research Technologies Development Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland 20892, USA"},{"name":"Department of Microbiology and Immunology, Driskill Graduate Program in the Life Sciences, Northwestern University , Chicago, Illinois 60611, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia O","family":"Krumholz","sequence":"additional","affiliation":[{"name":"Inflammation Immunobiology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland 20892, USA"},{"name":"Research Technologies Development Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland 20892, USA"},{"name":"Boston University School of Medicine , Boston, Massachusetts 02118, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin B","family":"Lack","sequence":"additional","affiliation":[{"name":"NIAID Collaborative Bioinformatics Resource, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland 20892, USA"},{"name":"Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research , Frederick, Maryland 21701, 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