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Of the two isoforms of the enzyme, COX-2 has been shown to be induced in macrophages during inflammation. Although general COX inhibitors, belonging to the class of nonsteroidal anti-inflammatory drugs, or specific COX-2 inhibitors, called coxibs, are useful in the control of acute inflammation, adverse reactions were seen when used chronically in the treatment of rheumatoid arthritis or neurodegenerative diseases. Extracellular ATP (eATP) has been reported as a damage-associated molecular pattern signal. In this report, we show that eATP synergistically increases the levels of COX-2 enzyme and PGE2 in LPS-activated RAW264.7 macrophages and human monocytes. Activation of macrophages also occurred when cultured in media obtained from dying neurons that contained higher levels of ATP. We show that eATP increases the levels of COX-2 protein, which is sustained up to 36 h poststimulation. This is in turn due to sustained levels of phosphorylated, or activated, cyclin-dependent kinase 9 and p38 MAPK in ATP-treated cells compared to LPS-stimulated cells. The eATP-dependent increase in COX-2\/PGE2 levels in LPS-activated RAW264.7 cells could be abolished using antagonists for purinergic P2X7\u00a0-and P2Y6 receptors. Similarly, the increase in COX-2\/PGE2 levels in the peritoneum of LPS-treated mice could be significantly abolished in mice that were preinjected with the nonspecific P2 receptor antagonist, suramin. P2 receptor antagonists, therefore, should be explored in our search for an ideal anti-inflammatory candidate.<\/jats:p>","DOI":"10.1002\/jlb.3a1219-697rr","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T11:56:12Z","timestamp":1610711772000},"page":"663-677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Exogenous ATP modulates PGE2 release in macrophages through sustained phosphorylation of CDK9 and p38 MAPK"],"prefix":"10.1093","volume":"110","author":[{"given":"Shamima","family":"Akter","sequence":"first","affiliation":[{"name":"Neuroinflammation Research Laboratory, Faculty of Life Sciences and Biotechnology, South Asian University , New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh Kumar","family":"Sharma","sequence":"additional","affiliation":[{"name":"Neuroinflammation Research Laboratory, Faculty of Life Sciences and Biotechnology, South Asian University , New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpa","family":"Sharma","sequence":"additional","affiliation":[{"name":"Neuroinflammation Research Laboratory, Faculty of Life Sciences and Biotechnology, South Asian University , New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saumya","family":"Rastogi","sequence":"additional","affiliation":[{"name":"Neuroinflammation Research Laboratory, Faculty of Life Sciences and Biotechnology, South Asian University , New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd L","family":"Fiebich","sequence":"additional","affiliation":[{"name":"Neuroimmunology and Neurochemistry Research Group, Department of Psychiatry and Psychotherapy, Faculty of Medicine, Medical Center\u2014University of Freiburg, University of Freiburg , Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi 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