{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:58:07Z","timestamp":1790636287655,"version":"4.1.0"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T00:00:00Z","timestamp":1538611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T00:00:00Z","timestamp":1538611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T00:00:00Z","timestamp":1538611200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006492","name":"NIAID Division of Intramural Research","doi-asserted-by":"publisher","award":["ZO1-AI000941-14"],"award-info":[{"award-number":["ZO1-AI000941-14"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["ZO1\u2010AI000941\u201014"],"award-info":[{"award-number":["ZO1\u2010AI000941\u201014"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,12,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Eosinophil peroxidase (EPX) is a major constituent of the large cytoplasmic granules of both human and mouse eosinophilic leukocytes. Human EPX deficiency is a rare, autosomal-recessive disorder limited to the eosinophil lineage. Our intent was to explore the impact of EPX gene deletion on eosinophil content, structure, and function. In response to repetitive intranasal challenge with a filtrate of the allergen, Alternaria alternata, we found significantly fewer eosinophils peripherally and in the respiratory tracts of EPX\u2212\/\u2212 mice compared to wild-type controls; furthermore, both the major population (Gr1\u2212\/lo) and the smaller population of Gr1hi eosinophils from EPX\u2212\/\u2212 mice displayed lower median fluorescence intensities (MFIs) for Siglec F. Quantitative evaluation of transmission electron micrographs of lung eosinophils confirmed the relative reduction in granule outer matrix volume in cells from the EPX\u2212\/\u2212 mice, a finding analogous to that observed in human EPX deficiency. Despite the reduced size of the granule matrix, the cytokine content of eosinophils isolated from allergen-challenged EPX\u2212\/\u2212 and wild-type mice were largely comparable to one another, although the EPX\u2212\/\u2212 eosinophils contained reduced concentrations of IL-3. Other distinguishing features of lung eosinophils from allergen-challenged EPX\u2212\/\u2212 mice included a reduced fraction of surface TLR4+ cells and reduced MFI for NOD1. Interestingly, the EPX gene deletion had no impact on eosinophil-mediated clearance of gram-negative Haemophilus influenzae from the airways. As such, although no clinical findings have been associated with human EPX deficiency, our findings suggest that further evaluation for alterations in eosinophil structure and function may be warranted.<\/jats:p>\n               <jats:p>Eosinophils from the lungs of allergen-challenged EPX\u2212\/\u2212 mice display differential expression of Siglec F and maintain reduced quantities of IL-3.<\/jats:p>","DOI":"10.1002\/jlb.3ab0318-090rr","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T21:39:03Z","timestamp":1538775543000},"page":"151-161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Impact of eosinophil-peroxidase (EPX) deficiency on eosinophil structure and function in mouse airways"],"prefix":"10.1093","volume":"105","author":[{"given":"Caroline M","family":"Percopo","sequence":"first","affiliation":[{"name":"Inflammation Immunobiology Section, Bethesda , Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia O","family":"Krumholz","sequence":"additional","affiliation":[{"name":"Inflammation Immunobiology Section, Bethesda , Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth R","family":"Fischer","sequence":"additional","affiliation":[{"name":"Research Technologies Branch, NIH , Hamilton, Montana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura S","family":"Kraemer","sequence":"additional","affiliation":[{"name":"Inflammation Immunobiology Section, Bethesda , Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Ma","sequence":"additional","affiliation":[{"name":"Inflammation Immunobiology Section, Bethesda , Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Laky","sequence":"additional","affiliation":[{"name":"Food Allergy Research Unit, NIH , Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene F","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Inflammation Immunobiology Section, Bethesda , Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,10,4]]},"reference":[{"key":"2023032406265681100_jlb10248-cit-0001","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nri3341","article-title":"Eosinophils: changing perspectives in health and disease","volume":"13","author":"Rosenberg","year":"2013","journal-title":"Nature Reviews Immunol"},{"key":"2023032406265681100_jlb10248-cit-0002","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/nri.2017.95","article-title":"Functions of tissue-resident eosinophils","volume":"17","author":"Weller","year":"2017","journal-title":"Nature Reviews Immunol"},{"key":"2023032406265681100_jlb10248-cit-0003","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40413-016-0112-5","article-title":"Eosinophilic bioactivities in severe asthma","volume":"9","author":"Carr","year":"2016","journal-title":"World Allergy Organ J"},{"key":"2023032406265681100_jlb10248-cit-0004","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jaci.2017.09.022","article-title":"Eosinophils and eosinophil-associated diseases: an update","volume":"141","author":"O'Sullivan","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"2023032406265681100_jlb10248-cit-0005","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1007\/s11894-006-0024-6","article-title":"Eosinophils in the gastrointestinal tract","volume":"8","author":"Lamouse-Smith","year":"2006","journal-title":"Curr Gastroenterol Rep"},{"key":"2023032406265681100_jlb10248-cit-0006","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1189\/jlb.3RI0416-202R","article-title":"Eosinophils, probiotics and the microbiome","volume":"100","author":"Rosenberg","year":"2016","journal-title":"J Leukoc Biol"},{"key":"2023032406265681100_jlb10248-cit-0007","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.immuni.2014.02.014","article-title":"Eosinophils promote generation and maintenance of immunoglobulin-A-expressing plasma cells and contribute to gut immune homeostasis","volume":"40","author":"Chu","year":"2014","journal-title":"Immunity"},{"key":"2023032406265681100_jlb10248-cit-0008","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/mi.2014.123","article-title":"IL-1beta in eosinophil-mediated small intestinal homeostasis and IgA production","volume":"8","author":"Jung","year":"2015","journal-title":"Mucosal Immunol"},{"key":"2023032406265681100_jlb10248-cit-0009","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.celrep.2016.06.007","article-title":"Microbiota-regulated IL-25 increases eosinophil number to provide protection during Clostridium difficile infection","volume":"16","author":"Buonomo","year":"2016","journal-title":"Cell Rep"},{"key":"2023032406265681100_jlb10248-cit-0010","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20172049","article-title":"Eosinophils suppress Th1 responses and restrict bacterially induced gastrointestinal inflammation","author":"Arnold","year":"2018","journal-title":"J Exp Med in press"},{"key":"2023032406265681100_jlb10248-cit-0011","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/all.12169","article-title":"The consequences of not having eosinophils","volume":"68","author":"Gleich","year":"2013","journal-title":"Allergy"},{"key":"2023032406265681100_jlb10248-cit-0012","doi-asserted-by":"crossref","first-page":"17406","DOI":"10.1074\/jbc.R113.546218","article-title":"Eosinophil granule proteins: form and function","volume":"289","author":"Acharya","year":"2014","journal-title":"J Biol Chem"},{"key":"2023032406265681100_jlb10248-cit-0013","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1084\/jem.118.2.277","article-title":"Isolation of granules from eosinophil leucocytes and study of their enzyme content","volume":"118","author":"Archer","year":"1963","journal-title":"J Exp Med"},{"key":"2023032406265681100_jlb10248-cit-0014","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/0003-9861(72)90164-6","article-title":"Guinea pig heterophil and eosinophil peroxidase","volume":"148","author":"Desser","year":"1972","journal-title":"Arch Biochem Biophys"},{"key":"2023032406265681100_jlb10248-cit-0015","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0167-4838(82)90112-1","article-title":"Purification of horse eosinophil peroxidase","volume":"701","author":"J\u00f6rg","year":"1982","journal-title":"Biochim Biophys Acta"},{"key":"2023032406265681100_jlb10248-cit-0016","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1084\/jem.169.5.1757","article-title":"Molecular cloning of the human eosinophil peroxidase. Evidence for the existence of a peroxidase multigene family","volume":"169","author":"Ten","year":"1989","journal-title":"J Exp Med"},{"key":"2023032406265681100_jlb10248-cit-0017","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/jlb.60.2.285","article-title":"Cloning of the murine eosinophil peroxidase gene (mEPO): characterization of a conserved subgroup of mammalian hematopoietic peroxidases","volume":"60","author":"Horton","year":"1996","journal-title":"J Leukoc Biol"},{"key":"2023032406265681100_jlb10248-cit-0018","doi-asserted-by":"crossref","first-page":"27914","DOI":"10.1016\/S0021-9258(18)46874-3","article-title":"Eosinophil peroxidase-dependent hydroxyl radical generation by human eosinophils","volume":"269","author":"McCormick","year":"1994","journal-title":"J Biol Chem"},{"key":"2023032406265681100_jlb10248-cit-0019","doi-asserted-by":"crossref","first-page":"25933","DOI":"10.1074\/jbc.274.36.25933","article-title":"Eosinophil peroxidase nitrates protein tyrosyl residues. Implications for oxidative damage by nitrating intermediates in eosinophilic inflammatory disorders","volume":"274","author":"Wu","year":"1999","journal-title":"J Biol Chem"},{"key":"2023032406265681100_jlb10248-cit-0020","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.4049\/jimmunol.124.3.1378","article-title":"Bactericidal activity of eosinophil peroxidase","volume":"124","author":"Jong","year":"1980","journal-title":"J Immunol"},{"key":"2023032406265681100_jlb10248-cit-0021","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1128\/iai.44.2.534-536.1984","article-title":"Toxic effect of the peroxidase-hydrogen peroxide-halide antimicrobial system on Mycobacterium leprae","volume":"44","author":"Klebanoff","year":"1984","journal-title":"Infect Immun"},{"key":"2023032406265681100_jlb10248-cit-0022","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1159\/000206611","article-title":"Ultrastructure of human eosinophils genetically lacking peroxidase","volume":"71","author":"Presentey","year":"1984","journal-title":"Acta Haematol"},{"key":"2023032406265681100_jlb10248-cit-0023","first-page":"574","article-title":"The incidence of peroxidase and phospholipid deficiency in eosinophilic granulocytes among various Jewish groups in Israel","volume":"22","author":"Joshua","year":"1970","journal-title":"Am J Hum Genet"},{"key":"2023032406265681100_jlb10248-cit-0024","doi-asserted-by":"crossref","first-page":"12496","DOI":"10.1073\/pnas.91.26.12496","article-title":"Hereditary eosinophil peroxidase deficiency: immunochemical and spectroscopic studies and evidence for a compound heterozygosity of the defect","volume":"91","author":"Romano","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023032406265681100_jlb10248-cit-0025","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/humu.10","article-title":"Eosinophilic peroxidase deficiency: identification of a point mutation (D648N) and prediction of structural changes","volume":"17","author":"Nakagawa","year":"2001","journal-title":"Human Mutation"},{"key":"2023032406265681100_jlb10248-cit-0026","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.4049\/jimmunol.167.3.1672","article-title":"Extensive eosinophil degranulation and peroxidase-mediated oxidation of airway proteins do not occur in a mouse ovalbumin-challenge model of pulmonary inflammation","volume":"167","author":"Denzler","year":"2001","journal-title":"J Immunol"},{"key":"2023032406265681100_jlb10248-cit-0027","doi-asserted-by":"crossref","first-page":"5509","DOI":"10.4049\/jimmunol.165.10.5509","article-title":"Eosinophil major basic protein-1 does not contribute to allergen-induced airway pathologies in mouse models of asthma","volume":"165","author":"Denzler","year":"2000","journal-title":"J Immunol"},{"key":"2023032406265681100_jlb10248-cit-0028","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1182\/blood-2013-01-473405","article-title":"Expression of the secondary granule proteins major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX) is required for eosinophilopoiesis in mice","volume":"122","author":"Doyle","year":"2013","journal-title":"Blood"},{"key":"2023032406265681100_jlb10248-cit-0029","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1189\/jlb.3A0416-166R","article-title":"Siglec F+Gr1hi eosinophils are a distinct subpopulation within the lungs of allergen-challenged mice","volume":"101","author":"Percopo","year":"2017","journal-title":"J Leukoc Biol"},{"key":"2023032406265681100_jlb10248-cit-0030","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nri2510","article-title":"Towards an understanding of the adjuvant action of aluminum","volume":"9","author":"Marrack","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"2023032406265681100_jlb10248-cit-0031","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.jaci.2007.12.1164","article-title":"Exposure to multiple indoor allergens in US homes and its relationship to asthma","volume":"121","author":"Salo","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"2023032406265681100_jlb10248-cit-0032","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s12890-017-0494-3","article-title":"Detection of pathogens by real-time PCR in adult patients with acute exacerbation of bronchial asthma","volume":"17","author":"Yoshii","year":"2017","journal-title":"BMC Pulm Med"},{"key":"2023032406265681100_jlb10248-cit-0033","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/resp.12734","article-title":"COPD is characterized by increased detection of Haemophilus influenzae, Streptococcus pneumoniae and a deficiency of Bacillus species","volume":"21","author":"Simpson","year":"2016","journal-title":"Respirology"},{"key":"2023032406265681100_jlb10248-cit-0034","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.15252\/emmm.201505088","article-title":"Haemophilus influenzae responds to glucocorticoids used in asthma therapy by modulation of biofilm formation and antibiotic resistance","volume":"7","author":"Earl","year":"2015","journal-title":"EMBO Mol Med"},{"key":"2023032406265681100_jlb10248-cit-0035","first-page":"1387","article-title":"Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. J. Exp","volume":"195","author":"Yu","year":"2002","journal-title":"Med"},{"key":"2023032406265681100_jlb10248-cit-0036","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.4049\/jimmunol.181.6.4004","article-title":"Functionally competent eosinophils differentiated ex vivo in high purity from normal mouse bone marrow","volume":"181","author":"Dyer","year":"2008","journal-title":"J Immunol"},{"key":"2023032406265681100_jlb10248-cit-0037","first-page":"19","article-title":"A flow-cytometric method to evaluate eosinophil-mediated uptake of probiotic Lactobacillus reuteri. J. Microbiol","volume":"137","author":"Kraemer","year":"2017","journal-title":"Methods"},{"key":"2023032406265681100_jlb10248-cit-0038","first-page":"6D.1.1","article-title":"Laboratory Growth and Maintenance of Haemophilis influenzae","author":"Johnston","year":"2010","journal-title":"Curr Protoc Microbiol"},{"key":"2023032406265681100_jlb10248-cit-0039","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/cea.13050","article-title":"Eosinophil persistence in vivo and sustained viability ex vivo in response to respiratory challenge with fungal allergens","volume":"48","author":"Geslewitz","year":"2018","journal-title":"Clin Exp Allergy"},{"key":"2023032406265681100_jlb10248-cit-0040","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.4049\/jimmunol.1102832","article-title":"IL-33 responsive lineage CD25+CD44\u2212hi lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs","volume":"188","author":"Bartemes","year":"2012","journal-title":"J Immunol"},{"key":"2023032406265681100_jlb10248-cit-0041","doi-asserted-by":"crossref","first-page":"570","DOI":"10.3389\/fimmu.2014.00570","article-title":"Eosinophil cytokines, chemokines and growth factors: emerging roles in immunity","volume":"5","author":"Davoine","year":"2014","journal-title":"Front Immunol"},{"key":"2023032406265681100_jlb10248-cit-0042","doi-asserted-by":"crossref","first-page":"496","DOI":"10.3389\/fimmu.2014.00496","article-title":"Eosinophil secretion of granule-derived cytokines","volume":"5","author":"Spencer","year":"2014","journal-title":"Front Immunol"},{"key":"2023032406265681100_jlb10248-cit-0043","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1189\/jlb.0803391","article-title":"Eosinophil degranulation in the allergic lung of mice primarily occurs in the airway lumen","volume":"75","author":"Clark","year":"2004","journal-title":"J Leukoc Biol"},{"key":"2023032406265681100_jlb10248-cit-0044","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.jaci.2012.07.025","article-title":"Human versus mouse eosinophils: \u201cthat which we call an eosinophil, by any other name would stain as red\u201d","volume":"130","author":"Lee","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"2023032406265681100_jlb10248-cit-0045","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1189\/jlb.0108058","article-title":"Human eosinophils constitutively express multiple Th1, Th2, and immunoregulatory cytokines that are secreted rapidly and differentially","volume":"85","author":"Spencer","year":"2009","journal-title":"J Leukoc Biol"},{"key":"2023032406265681100_jlb10248-cit-0046","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1084\/jem.174.3.745","article-title":"Granulocyte\/macrophage colony-stimulating factor and interleukin 3 release from human peripheral blood eosinophils and neutrophils","volume":"174","author":"Kita","year":"1991","journal-title":"J Exp Med"},{"key":"2023032406265681100_jlb10248-cit-0047","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3389\/fmed.2017.00116","article-title":"Glycobiology of eosinophilic inflammation: contribution of Siglecs, glycans and other glycan-binding proteins","volume":"4","author":"O'Sullivan","year":"2017","journal-title":"Front Med"},{"key":"2023032406265681100_jlb10248-cit-0048","first-page":"429","article-title":"Essential mechanisms of differential activation of eosinophils by IL-3 compared to GM-CSF and IL-5","volume":"36","author":"Esnault","year":"2016","journal-title":"Crit Rev Immunol"},{"key":"2023032406265681100_jlb10248-cit-0049","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1165\/ajrcmb.23.3.3707","article-title":"The effect of trans-endothelial migration on eosinophil function","volume":"23","author":"Yamamoto","year":"2000","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2023032406265681100_jlb10248-cit-0050","doi-asserted-by":"crossref","first-page":"4280","DOI":"10.1182\/blood-2006-08-039255","article-title":"Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils","volume":"109","author":"Zhang","year":"2007","journal-title":"Blood"},{"key":"2023032406265681100_jlb10248-cit-0051","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.imlet.2014.03.008","article-title":"Siglec F-dependent negative regulation of allergen-induced eosinophilia depends critically on the experimental model","volume":"160","author":"McMillan","year":"2014","journal-title":"Immunol Lett"},{"key":"2023032406265681100_jlb10248-cit-0052","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/138945006775270204","article-title":"Asthma, allergy and chemokines","volume":"7","author":"Pease","year":"2006","journal-title":"Curr Drug Targets"},{"key":"2023032406265681100_jlb10248-cit-0053","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jim.2011.04.009","article-title":"Antigen profiles for the quantitative assessment of eosinophils in mouse lung tissues by flow cytometry","volume":"369","author":"Dyer","year":"2011","journal-title":"J Immunol Methods"},{"key":"2023032406265681100_jlb10248-cit-0054","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1189\/jlb.0113014","article-title":"Ly6 family proteins in neutrophil biology","volume":"94","author":"Lee","year":"2013","journal-title":"J Leukoc Biol"},{"key":"2023032406265681100_jlb10248-cit-0055","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1365-2567.2012.03556.x","article-title":"Pattern recognition receptors in human eosinophils","volume":"136","author":"Kvarnhammar","year":"2012","journal-title":"Immunology"},{"key":"2023032406265681100_jlb10248-cit-0056","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/MOG.0b013e32835ab29a","article-title":"Eosinophils and intestinal immunity","volume":"29","author":"Hogan","year":"2013","journal-title":"Curr Opin Gastroenterol"},{"key":"2023032406265681100_jlb10248-cit-0057","doi-asserted-by":"crossref","first-page":"6978936","DOI":"10.1155\/2016\/6978936","article-title":"The role of toll-like receptor 4 in infectious and noninfectious inflammation","volume":"2016","author":"Molteni","year":"2016","journal-title":"Mediators Inflamm"},{"key":"2023032406265681100_jlb10248-cit-0058","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/nm.1946","article-title":"House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells","volume":"15","author":"Hammad","year":"2009","journal-title":"Nat Med"},{"key":"2023032406265681100_jlb10248-cit-0059","doi-asserted-by":"crossref","first-page":"5856\u20145862","DOI":"10.4049\/jimmunol.176.10.5856","article-title":"TLR4 signaling attenuates ongoing allergic inflammation","volume":"176","author":"Hollingsworth","year":"2006","journal-title":"J Immunol"},{"key":"2023032406265681100_jlb10248-cit-0060","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1165\/rcmb.2003-0435OC","article-title":"Toll-like receptor 4 or 2 agonists decrease allergic inflammation","volume":"32","author":"Velasco","year":"2005","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2023032406265681100_jlb10248-cit-0061","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.4049\/jimmunol.171.2.1001","article-title":"Bacterial lipopolysaccharide signaling through Toll-like receptor 4 suppresses asthma-like responses via nitric oxide synthase 2 activity","volume":"171","author":"Rodr\u00edguez","year":"2003","journal-title":"J Immunol"},{"key":"2023032406265681100_jlb10248-cit-0062","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/sji.12554","article-title":"TLR-Stimulated eosinophils mediate recruitment and activation of NK cells in vivo","volume":"85","author":"O'Flaherty","year":"2017","journal-title":"Scand J Immunol"},{"key":"2023032406265681100_jlb10248-cit-0063","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.it.2017.07.004","article-title":"NOD1 and NOD2: beyond peptidoglycan sensing","volume":"38","author":"Keestra-Gounder","year":"2017","journal-title":"Trends Immunol"},{"key":"2023032406265681100_jlb10248-cit-0064","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1365-2567.2011.03492.x","article-title":"NOD-like receptors and RIG-I-like receptors in human eosinophils: activation of NOD1 and NOD2 agonists","volume":"134","author":"Mansso","year":"2011","journal-title":"Immunology"},{"key":"2023032406265681100_jlb10248-cit-0065","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/cmi.2012.77","article-title":"NOD-like receptors medicated activation of eosinophils interacting with bronchial epithelial cells: a link between innate immunity and allergic asthma","volume":"10","author":"Wong","year":"2013","journal-title":"Cell Mol Immunol"},{"key":"2023032406265681100_jlb10248-cit-0066","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/nm.1855","article-title":"Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense","volume":"14","author":"Yousefi","year":"2008","journal-title":"Nat Med"},{"key":"2023032406265681100_jlb10248-cit-0067","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.abb.2005.10.008","article-title":"Role of eosinophil peroxidase in host defense and disease pathology","volume":"445","author":"Wang","year":"2006","journal-title":"Arch Biochem Biophys"},{"key":"2023032406265681100_jlb10248-cit-0068","doi-asserted-by":"crossref","first-page":"17415","DOI":"10.1074\/jbc.M112400200","article-title":"A tale of two controversies: defining both the role of peroxidases in nitrosotyrosine formation in vivo using eosinophil peroxidase and myeloperoxidase-deficient mice and the nature of peroxidase-generated reactive nitrogen species","volume":"277","author":"Brennan","year":"2002","journal-title":"J Biol Chem"},{"key":"2023032406265681100_jlb10248-cit-0069","doi-asserted-by":"crossref","first-page":"22118","DOI":"10.1074\/jbc.M116.750034","article-title":"Eosinophil peroxidase catalyzed protein carbamylation participates in asthma","volume":"291","author":"Wang","year":"2016","journal-title":"J Biol Chem"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2FJLB.3AB0318-090RR","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JLB.3AB0318-090RR","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/JLB.3AB0318-090RR","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/105\/1\/151\/49557380\/jlb10248.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/105\/1\/151\/49557380\/jlb10248.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T06:37:47Z","timestamp":1679639867000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/105\/1\/151\/6935571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,4]]},"references-count":69,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,10,4]]},"published-print":{"date-parts":[[2018,12,27]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.3ab0318-090rr","relation":{},"ISSN":["1938-3673","0741-5400"],"issn-type":[{"value":"1938-3673","type":"electronic"},{"value":"0741-5400","type":"print"}],"subject":[],"published-other":{"date-parts":[[2019,1]]},"published":{"date-parts":[[2018,10,4]]}}}