{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:15:45Z","timestamp":1778656545317,"version":"3.51.4"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"CONACyT Ciencia B\u00e1sica","award":["258738"],"award-info":[{"award-number":["258738"]}]},{"name":"CONACyT Ciencia B\u00e1sica","award":["258738"],"award-info":[{"award-number":["258738"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Mast cell activation through the high-affinity IgE receptor (Fc\u03b5RI) plays a central role in allergic reactions. Fc\u03b5RI-mediated activation triggers multiple signaling pathways leading to degranulation and synthesis of different inflammatory mediators. IgE-mediated mast cell activation can be modulated by different molecules, including several drugs. Herein, we investigated the immunomodulatory activity of the histone deacetylase inhibitor valproic acid (VPA) on IgE-mediated mast cell activation. To this end, bone marrow-derived mast cells (BMMC) were sensitized with IgE and treated with VPA followed by Fc\u03b5RI cross-linking. The results indicated that VPA reduced mast cell IgE-dependent degranulation and cytokine release. VPA also induced a significant reduction in the cell surface expression of Fc\u03b5RI and CD117, but not other mast cell surface molecules. Interestingly, VPA treatment inhibited the phosphorylation of PLC\u03b32, a key signaling molecule involved in IgE-mediated degranulation and cytokine secretion. However, VPA did not affect the phosphorylation of other key components of the Fc\u03b5RI signaling pathway, such as Syk, Akt, ERK1\/2, or p38. Altogether, our data demonstrate that VPA affects PLC\u03b32 phosphorylation, which in turn decreases IgE-mediated mast cell activation. These results suggest that VPA might be a key modulator of allergic reactions and might be a promising therapeutic candidate.<\/jats:p>","DOI":"10.1002\/jlb.3ab0320-547rr","type":"journal-article","created":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T21:08:16Z","timestamp":1591045696000},"page":"859-866","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The histone deacetylase inhibitor valproic acid attenuates phospholipase C\u03b32 and IgE-mediated mast cell activation"],"prefix":"10.1093","volume":"108","author":[{"given":"Gloria Mariana","family":"Rodr\u00edguez-L\u00f3pez","sequence":"first","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional , ENCB-IPN, Mexico City , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo","family":"Soria-Castro","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional , ENCB-IPN, Mexico City , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia","family":"Campillo-Navarro","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda Integrativa, Instituto Nacional de Enfermedades Respiratorias Ismael Cos\u00edo Villegas , Mexico City , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia Mayra","family":"P\u00e9rez-Tapia","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional , ENCB-IPN, Mexico City , Mexico"},{"name":"Unidad de Desarrollo e Investigaci\u00f3n en Bioprocesos (UDIBI), Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional , ENCB-IPN, Mexico City , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabi\u00e1n","family":"Flores-Borja","sequence":"additional","affiliation":[{"name":"Centre for Immunobiology and Regenerative Medicine, Barts & The London School of Medicine and Dentistry, Queen Mary University of London , London , United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Wong-Baeza","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional , ENCB-IPN, Mexico City , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samira","family":"Mu\u00f1oz-Cruz","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Infecciosas y Parasitarias, UMAE Hospital de Pediatr\u00eda, Centro M\u00e9dico Siglo XXI, Instituto Mexicano del Seguro Social , Mexico City , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rub\u00e9n","family":"L\u00f3pez-Santiago","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional , ENCB-IPN, Mexico City , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Estrada-Parra","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional , ENCB-IPN, Mexico City , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Estrada-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional , ENCB-IPN, Mexico City , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alma Delia","family":"Ch\u00e1vez-Blanco","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Ciencia B\u00e1sica, Instituto Nacional de Cancerolog\u00eda (INCan) , Mexico City , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4500-0253","authenticated-orcid":true,"given":"Rommel","family":"Chac\u00f3n-Salinas","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional , ENCB-IPN, Mexico City , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,6,1]]},"reference":[{"key":"2023032108163244300_jlb10639-cit-0001","doi-asserted-by":"crossref","first-page":"e83","DOI":"10.1038\/emm.2014.7","article-title":"New era for mucosal mast cells: their roles in inflammation, allergic immune 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